Results 21 to 30 of about 498,979 (245)
NF-κB, the first quarter-century: remarkable progress and outstanding questions.
Genes & Development, 2012 The ability to sense and adjust to the environment is crucial to life. For multicellular organisms, the ability to respond to external changes is essential not only for survival but also for normal development and physiology.
M. S. Hayden, S. Ghosh
semanticscholar +1 more source
Fatty Acid Metabolism Provides an Essential Survival Signal in OxPhos and BCR DLBCL Cells
BiomedicinesBackgroung/objectives: Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of malignant lymphoma and is a heterogeneous disease with various gene and chromosomal abnormalities.
Aurélie Montagne +7 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2004 Aberrant nuclear factor-κB (NF-κB) activation has been implicated in the pathogenesis of several human malignancies. In this study, we determined whether NF-κB is constitutively activated in human prostate adenocarcinoma, and, if so, whether increased NF-
Sanjeev Shukla +6 more
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NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
Frontiers in Oncology, 2023 IntroductionImproving treatments for Diffuse Large B-Cell Lymphoma (DLBCL) is challenged by the vast heterogeneity of the disease. Nuclear factor-κB (NF-κB) is frequently aberrantly activated in DLBCL. Transcriptionally active NF-κB is a dimer containing
Eleanor Jayawant +8 more
doaj +1 more source
The Ubiquitination of NF-κB Subunits in the Control of Transcription
Cells, 2016 Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors fundamental in the control of the inflammatory response. The transcription of hundreds of genes involved in inflammation and immune homeostasis require NF-κB ...
Patricia E. Collins +2 more
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NF-κB in monocytes and macrophages – an inflammatory master regulator in multitalented immune cells
Frontiers in Immunology, 2023 Nuclear factor κB (NF-κB) is a dimeric transcription factor constituted by two of five protein family members. It plays an essential role in inflammation and immunity by regulating the expression of numerous chemokines, cytokines, transcription factors ...
Marion Mussbacher +3 more
semanticscholar +1 more source
Scientific Reports, 2017 Transcription factor NF-κB plays a central role in immunity from fruit flies to humans, and NF-κB activity is altered in many human diseases. To investigate a role for NF-κB in immunity and disease on a broader evolutionary scale we have characterized NF-
Katelyn M. Mansfield +11 more
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Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain
Journal of Neuroinflammation, 2019 Background While NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging-associated microglial pro-inflammatory priming is poorly understood ...
Thomas Taetzsch +4 more
doaj +1 more source
NF-κB in biology and targeted therapy: new insights and translational implications
Signal Transduction and Targeted TherapyNF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses.
Qing Guo +8 more
semanticscholar +1 more source
The levels of NF-κB p50 and NF-κB p65 play a role in thyroid carcinoma malignancy in vivo
Journal of International Medical Research, 2018 Background To investigate the relationship between the levels of nuclear factor (NF)-κB p50 and NF-κB p65 and tumour characteristics in patients with thyroid carcinoma.
Fei Le +4 more
doaj +1 more source