Results 31 to 40 of about 498,979 (245)
NF-κB: At the Borders of Autoimmunity and Inflammation
Frontiers in Immunology, 2021 The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory response.
L. Barnabei +4 more
semanticscholar +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Blood Advances: Early detection of ultrahigh-risk diffuse large B-cell lymphoma (DLBCL) is an unmet medical need to aid patient stratification for alternative treatment approaches.
Aurélie Montagne +18 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The cGAS-STING pathway is important for immune defense against infection and cancer. STING activation triggers multiple signaling cascades leading to activation of IRF3, NF-κB, and autophagy.
S. Yum +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Cell Death and DiseaseCellular responses to TNF are inherently heterogeneous within an isogenic cell population and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF-κB and MAPK signalling pathways but may also trigger apoptosis and ...
Marcus K. Preedy +2 more
doaj +1 more source
BiomedicinesBackground: Gastric cancer (GC) is a highly heterogeneous disease and remains one of the major causes of cancer-related mortality worldwide. The vast majority of GC cases are adenocarcinomas including diffuse and intestinal GC that may differ in their ...
Cynthia Pimpie +4 more
doaj +1 more source
The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability
Frontiers in Immunology, 2019 Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology.
Emilie Ronin +10 more
doaj +1 more source
New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks
Biology, 2023 The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation.
Dominga Iacobazzi +5 more
doaj +1 more source
The role of NF-κB in breast cancer initiation, growth, metastasis, and resistance to chemotherapy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023 Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB.
E. Pavitra +12 more
semanticscholar +1 more source