Results 1 to 10 of about 396,196 (289)
NF‐κB signaling in inflammation and cancer
MedComm, 2021 Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered in 1986, extraordinary efforts have been made to understand the function and regulating mechanism of NF‐κB for 35 years, which lead to significant progress ...
Tao Zhang +4 more
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Hepatology Communications, 2021 Drug‐induced hepatotoxicity limits development of new effective medications. Drugs and numerous endogenous/exogenous agents are metabolized/detoxified by hepatocytes, during which reactive oxygen species (ROS) are generated as a by‐product. ROS has broad
Xiao Zhong +7 more
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Immunity, Inflammation and Disease, 2023 Objective In this study, the therapeutic effect of quinic acid (QA), which has anti‐inflammatory activity, was investigated on acetic acid‐induced colitis in male Wistar rats.
Maryam Ghasemi‐Dehnoo +4 more
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NF-kB decoy oligodeoxynucleotide preserves disc height in a rabbit anular-puncture model and reduces pain induction in a rat xenograft-radiculopathy model [PDF]
European Cells & Materials, 2021 While it is known that the degenerated intervertebral disc (IVD) is one of the primary reasons for low-back pain and subsequent need for medical care, there are currently no established effective methods for direct treatment. Nuclear factor-κB (NF-κB) is
K Kato +12 more
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NF-kappa B activation correlates with disease phenotype in Crohn's disease. [PDF]
PLoS ONE, 2017 Unregulated activation of nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of Crohn's disease. In this study, we investigated the clinical characteristics and disease outcome of Crohn's disease patients with varying levels of the NF-κB
Yoo Min Han +8 more
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TLR7, TLR9, MyD88, and NF-κB role on platelet aggregation in Yucatecan patients with type 2 diabetes
Alad, 2022 Objective: To analyze the expression of TLR7, TLR9, and signaling proteins MyD88 and NF-κB, and their relationship with platelet aggregation in Yucatecan patients with type 2 diabetes. Material and methods: Platelet aggregation was determined by light transmission and protein expression by flow cytometry in 31 patients and 29 controls from Yucatan ...
LucÃa G. González-Espinosa +7 more
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NF-κB signaling regulates myelination in the CNS [PDF]
Frontiers in Molecular Neuroscience, 2014 Besides myelination of neuronal axons by oligodendrocytes to facilitate propagation of action potentials, oligodendrocytes also support axon survival and function. A key transcription factor involved in these processes is nuclear factor-κB (NF-κB), a hetero or homodimer of the Rel family of proteins, including p65, c-Rel, RelB, p50, and p52.
Thomas eBlank +2 more
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NF-κB and Human Cancer: What Have We Learned over the Past 35 Years?
Biomedicines, 2021 Transcription factor NF-κB has been extensively studied for its varied roles in cancer development since its initial characterization as a potent retroviral oncogene. It is now clear that NF-κB also plays a major role in a large variety of human cancers,
Thomas D. Gilmore
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Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions
Cells, 2016 The family of NF-κB transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development.
Véronique Baud, Davi Collares
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Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression [PDF]
Nature Communications, 2018 AbstractKnowledge of stromal factors that have a role in the transcriptional regulation of metabolic pathways aside from c-Myc is fundamental to improvements in lymphoma therapy. Using a MYC-inducible human B-cell line, we observed the cooperative activation of STAT3 and NF-κB by IL10 and CpG stimulation.
Feist, M. +18 more
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