Results 1 to 10 of about 323,087 (182)
NF-κB signaling in inflammation
Signal Transduction and Targeted Therapy, 2017 The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses.
Ting Liu +3 more
semanticscholar +1 more source
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
Signal Transduction and Targeted Therapy, 2020 NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is activated by various stimuli, transducing a quick but transient transcriptional activity, to regulate the expression of various proinflammatory genes and also serve as
Hui Yu +4 more
semanticscholar +1 more source
The complexity of NF-κB signaling in inflammation and cancer
Molecular Cancer, 2013 The NF-κB family of transcription factors has an essential role in inflammation and innate immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of cancer initiation and progression. During these latter processes NF-κB
B. Hoesel, J. Schmid
semanticscholar +1 more source
NF-κB: a key role in inflammatory diseases
, 2001 Activation of the NF-κB/Rel transcription family, by nuclear translocation of cytoplasmic complexes, plays a central role in inflammation through its ability to induce transcription of proinflammatory genes (1). This pathway is activated upon appropriate
P. Tak, G. Firestein
semanticscholar +1 more source
NF-κB, the first quarter-century: remarkable progress and outstanding questions.
Genes & Development, 2012 The ability to sense and adjust to the environment is crucial to life. For multicellular organisms, the ability to respond to external changes is essential not only for survival but also for normal development and physiology.
M. Hayden, S. Ghosh
semanticscholar +1 more source
The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s Disease
International Journal of Molecular Sciences, 2022 Alzheimer’s Disease (AD) is the most common neurodegenerative disease worldwide, with a high prevalence that is expected to double every 20 years.
Emily Sun +3 more
semanticscholar +1 more source
NF-κB in biology and targeted therapy: new insights and translational implications
Signal Transduction and Targeted TherapyNF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses.
Qing Guo +8 more
semanticscholar +1 more source
NF-κB: At the Borders of Autoimmunity and Inflammation
Frontiers in Immunology, 2021 The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory response.
L. Barnabei +4 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The cGAS-STING pathway is important for immune defense against infection and cancer. STING activation triggers multiple signaling cascades leading to activation of IRF3, NF-κB, and autophagy.
S. Yum +3 more
semanticscholar +1 more source
Dissecting the Crosstalk Between Nrf2 and NF-κB Response Pathways in Drug-Induced Toxicity
Frontiers in Cell and Developmental Biology, 2022 Nrf2 and NF-κB are important regulators of the response to oxidative stress and inflammation in the body. Previous pharmacological and genetic studies have confirmed crosstalk between the two.
Wen Gao +7 more
semanticscholar +1 more source