Results 111 to 120 of about 783,867 (386)

Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells [PDF]

, 2015
BACKGROUND: Dexamethasone suppressed inflammation and haemodynamic changes in an animal model of pulmonary arterial hypertension (PAH). A major target for dexamethasone actions is NF-κB, which is activated in pulmonary vascular cells and perivascular ...
Adcock, IM, Dorfmuller, P, Garfield, BE, Humbert, M, Meng, C, Montani, D, Perros, F, Price, LC, Shao, D, Wort, SJ, Zhu, J   +10 more
core   +2 more sources

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes

International Journal of Molecular Medicine, 2011
Several kinds of sesquiterpene lactones have been proven to inhibit NF-κB and to retard atherosclerosis by reducing lesion size and changing plaque composition. The anti-malarial artemisinin (Art) is a pure sesquiterpene lactone extracted from the Chinese herb Artemisia annua (qinghao, sweet wormwood).
Rujia Jiang, Jiatian Cao, Shu Meng, Ting Chen, Liansheng Wang, Changqian Wang, Zhouqing Huang, Yue Wang, Yuqi Fan   +8 more
openaire   +4 more sources

30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology [PDF]

Cell, 2017
NF-κB was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human ...
Zhang, Qiang, Lenardo, Michael J., Baltimore, David   +2 more
openaire   +5 more sources

An Anti-apoptotic Role of NF-κB in TNFα-induced Apoptosis in an Ameloblastoma Cell Line [PDF]

, 2008
Nuclear factor-κB (NF-κB) is involved in the promotion of cell survival in a variety of cell types. The present study focused on the role of NF-κB in TNFα-induced apoptosis in an ameloblastoma.
Hendarmin, Laifa, Higuchi, Yoshinori, Kawano, Shintaro, Mitsuyasu, Takeshi, Nakamura, Norifumi, Nakamura, Seiji, Nakao, Yu, Sandra, Ferry, Yoshiga, Daigo   +8 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

miR-203, fine-tunning neuroinflammation by juggling different components of NF‐κB signaling

Journal of Neuroinflammation, 2022
Background miR-203 was first indicated in maintaining skin homeostasis and innate immunity. Aberrant expression of miR-203 was found associated with pathological progressions of immune disorders, cancers, as well as neurodegenerations.
Shufang Li, Linpeng Li, Jieli Li, Xiaosheng Liang, Chao Song, Yi Zou   +5 more
doaj   +1 more source

Plant polyphenols as inhibitors of NF-κB induced cytokine production—a potential anti-inflammatory treatment for Alzheimer's disease? [PDF]

Frontiers in Molecular Neuroscience, 2015
Alzheimer’s disease (AD) is a neurodegenerative disorder that impacts the daily lives of many sufferers throughmemory loss as well as behavioral and cognitive changes. AD is themost common form of dementia. One in ten people over the age of 65, and around half of those over 85 have AD.
Karunaweera, Niloo (S31677), Raju, Ritesh (R17740), Gyengesi, Erika (R17270), Muench, Gerald (R12224)   +3 more
openaire   +3 more sources

Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways. [PDF]

, 2012
The NF-κB protein RelB controls dendritic cell (DC) maturation and may be targeted therapeutically to manipulate T cell responses in disease. Here we report that RelB promoted DC activation not as the expected RelB-p52 effector of the noncanonical NF-κB ...
Asagiri, Masataka, Davis-Turak, Jeremy, Fagerlund, Riku, Hoffmann, Alexander, Huang, Jenny Q, Kearns, Jeffrey D, Macal, Monica, Ponomarenko, Julia, Shih, Vincent F-S, Yu, Tony, Zuniga, Elina I   +10 more
core   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source