Results 121 to 130 of about 783,867 (386)

The Effects of Curcumin on NF-κB Level and Degree of Liver Fibrosis in Rat Liver Fibrosis

Jurnal Penyakit Dalam Indonesia, 2018
Introduction. Chronic inflammation is the main mechanism responsible for liver fibrosis. NF-κB regulates inflammation, wound healing, and cell death. Curcumin acts as an antiinflammatory, antifibrotic and induced apoptosis, one of them through resistance
Supriono, Bogi Pratomo, Dedy Indra Praja
doaj   +1 more source

A gene expression biomarker for predictive toxicology to identify chemical modulators of NF-κB.

PLoS ONE, 2022
The nuclear factor-kappa B (NF-κB) is a transcription factor with important roles in inflammation, immune response, and oncogenesis. Dysregulation of NF-κB signaling is associated with inflammation and certain cancers.
Katharine L Korunes, Jie Liu, Ruili Huang, Menghang Xia, Keith A Houck, J Christopher Corton   +5 more
doaj   +1 more source

Genetic analysis of NF- B/Rel transcription factors defines functional specificities [PDF]

The EMBO Journal, 2003
The NF-kappaB transcription factors consist of dimeric proteins of the Rel homology family. They activate many promoters containing highly divergent kappaB-site sequences. We have generated cell lines lacking individual and multiple NF-kappaB proteins and used them to establish interactions between components of the NF-kappaB-IkappaB signaling system ...
Hoffmann, Alexander, Leung, Thomas H., Baltimore, David   +2 more
openaire   +4 more sources

Circuitry of nuclear factor κB signaling [PDF]

, 2006
Over the past few years, the transcription factor nuclear factor (NF)-κB and the proteins that regulate it have emerged as a signaling system of pre-eminent importance in human physiology and in an increasing number of pathologies. While NF-κB is present
Baltimore, David, Hoffmann, Alexander
core  

Role of Novel Serine 316 Phosphorylation of the p65 Subunit of NF-κB in Differential Gene Regulation [PDF]

, 2015
Nuclear factor κB (NF-κB) is a central coordinator in immune and inflammatory responses. Constitutive NF-κB is often found in some types of cancers, contributing to oncogenesis and tumor progression. Therefore, knowing how NF-κB is regulated is important
Hartley, Antja-Voy, Lu, Tao, Martin, Matthew, Prabhu, Lakshmi, Wang, Benlian, Wei, Han, Zhao, Wei   +6 more
core   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

NF-κB Activation Exacerbates, but Is not Required for Murine Bmpr2-Related Pulmonary Hypertension

Diseases, 2014
Aim: The present study investigates the role of NF-κB in Bmpr2-related pulmonary hypertension (PH) using a murine model of PH with inducible overexpression of a cytoplasmic tail Bmpr2 mutation.
Megha Talati, Haitham Mutlak, Kirk B. Lane, Wei Han, Anna Hemnes, Outi Mutlak, Tom Blackwell, Rinat Zaynagetdinov, Timothy S. Blackwell, James West   +9 more
doaj   +1 more source

The caspase-3-p120-RasGAP module generates a NF-κB repressor in response to cellular stress. [PDF]

, 2015
The nuclear factor κB (NF-κB) transcription factor is a master regulator of inflammation. Short-term NF-κB activation is generally beneficial. However, sustained NF-κB might be detrimental, directly causing apoptosis of cells or leading to a persistent ...
Annibaldi, Annibaldi, Baker, Bakry, Baldwin, Barnes, Ben-Neriah, Ben-Neriah, Bonizzi, Bulat, Calabrese, Chaudhary, Chung, Cook, Courtois, Cross, Darding, Englmeier, Gardam, Gerondakis, Hu, Hutten, Jaeschke, Jordan, Kane, Khalil, Khalil, Kopp, Kreuz, Kudo, Kumar, Lamkanfi, Lamkanfi, Lange, Lawrence, Lawrence, Laychock, Li, Marchetti, May, Nemergut, Newton, Oeckinghaus, Oeckinghaus, Ozes, Pasparakis, Pasparakis, Perkins, Romashkova, Salmena, Schmidt, Sen, Sen, Stoven, Stratis, Su, Trahey, Vallabhapurapu, Verma, Viatour, Wambier, Weissgerber, Wen, Widmann, Wong, Yamamoto, Yang, Yang, Yang, Yang, Yang, Yang, Yoon   +72 more
core   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Protective effects of urocortin 2 against caerulein-induced acute pancreatitis. [PDF]

, 2019
Because little is known about the role of corticotropin-releasing factor (CRF) agonists in regulating responses in pancreatitis, we evaluated the effects of urocortin 2 (UCN2) and stressin1 in caerulein-induced acute pancreatitis (AP) model in rats. Male
Bhargava, Aditi, Chheda, Chintan, Hasdemir, Burcu, Pandol, Stephen J, Rivier, Jean, Tan, Tanya, Yuan, Jingzhen   +6 more
core   +1 more source