Results 11 to 20 of about 783,867 (386)
NF‐κB signaling in inflammation and cancer
MedComm, 2021 Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered in 1986, extraordinary efforts have been made to understand the function and regulating mechanism of NF‐κB for 35 years, which lead to significant progress ...
Tao Zhang +4 more
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Cell, 1996 We are grateful to Romunda Craft for help with preparing the manuscript and the Figures and Table.
Baeuerle, Patrick A., Baltimore, David
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Hepatology Communications, 2021 Drug‐induced hepatotoxicity limits development of new effective medications. Drugs and numerous endogenous/exogenous agents are metabolized/detoxified by hepatocytes, during which reactive oxygen species (ROS) are generated as a by‐product. ROS has broad
Xiao Zhong +7 more
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Immunity, Inflammation and Disease, 2023 Objective In this study, the therapeutic effect of quinic acid (QA), which has anti‐inflammatory activity, was investigated on acetic acid‐induced colitis in male Wistar rats.
Maryam Ghasemi‐Dehnoo +4 more
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NF-kB decoy oligodeoxynucleotide preserves disc height in a rabbit anular-puncture model and reduces pain induction in a rat xenograft-radiculopathy model [PDF]
European Cells & Materials, 2021 While it is known that the degenerated intervertebral disc (IVD) is one of the primary reasons for low-back pain and subsequent need for medical care, there are currently no established effective methods for direct treatment. Nuclear factor-κB (NF-κB) is
K Kato +12 more
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NF-kappa B activation correlates with disease phenotype in Crohn's disease. [PDF]
PLoS ONE, 2017 Unregulated activation of nuclear factor-κB (NF-κB) plays a critical role in the pathogenesis of Crohn's disease. In this study, we investigated the clinical characteristics and disease outcome of Crohn's disease patients with varying levels of the NF-κB
Yoo Min Han +8 more
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NF-κB and Human Cancer: What Have We Learned over the Past 35 Years?
Biomedicines, 2021 Transcription factor NF-κB has been extensively studied for its varied roles in cancer development since its initial characterization as a potent retroviral oncogene. It is now clear that NF-κB also plays a major role in a large variety of human cancers,
Thomas D. Gilmore
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NF-κB signaling in inflammation
Signal Transduction and Targeted Therapy, 2017 The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses.
Ting Liu +3 more
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Post-Translational Modifications of RelB NF-κB Subunit and Associated Functions
Cells, 2016 The family of NF-κB transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development.
Véronique Baud, Davi Collares
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Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
Signal Transduction and Targeted Therapy, 2020 NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is activated by various stimuli, transducing a quick but transient transcriptional activity, to regulate the expression of various proinflammatory genes and also serve as
Hui Yu +4 more
semanticscholar +1 more source