NF-κB: a key role in inflammatory diseases
, 2001 Activation of the NF-κB/Rel transcription family, by nuclear translocation of cytoplasmic complexes, plays a central role in inflammation through its ability to induce transcription of proinflammatory genes (1). This pathway is activated upon appropriate
P. Tak, G. Firestein
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The Ubiquitination of NF-κB Subunits in the Control of Transcription
Cells, 2016 Nuclear factor (NF)-κB has evolved as a latent, inducible family of transcription factors fundamental in the control of the inflammatory response. The transcription of hundreds of genes involved in inflammation and immune homeostasis require NF-κB ...
Patricia E. Collins +2 more
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Tumor Necrosis Factor-α Contributes to Ischemia- and Reperfusion-Induced Endothelial Activation in Isolated Hearts [PDF]
, 1999 During myocardial reperfusion, polymorphonuclear neutrophil (PMN) adhesion involving the intercellular adhesion molecule-1 (ICAM-1) may lead to aggravation and prolongation of reperfusion injury.
Becker, Bernhard F. +7 more
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Ginkgetin inhibits proliferation of HeLa cells via activation of p38/NF-κB pathway
Cellular and Molecular Biology, 2019 Effect of ginkgetin on proliferation of human cervical cancer (HeLa) cells and the underlying mechanism were investigated. Human cervical cancer (HeLa) cells were cultured at 37 °C in 10 % fetal bovine serum (FBS) supplemented RPMI 1640 medium in a humidified incubator containing 5 % CO2.
Jianping Kong, Yun Li, Jianxia Cheng
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NF-κB, the first quarter-century: remarkable progress and outstanding questions.
Genes & Development, 2012 The ability to sense and adjust to the environment is crucial to life. For multicellular organisms, the ability to respond to external changes is essential not only for survival but also for normal development and physiology.
M. Hayden, S. Ghosh
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Oncotarget, 2017 // Yi-Bin Wang 1, * , Yin Ni 2, * , Ren-Hua Sun 2 , Xiao-Zhou Mou 3 , Fang Han 2 , Qian Li 2 , Hai-Jun Huang 4 , Jing-Quan Liu 2 and Yue-Xing Tu 2 1 Department of Cardiology, Chun’an First People’s Hospital, Zhejiang Provincial People’s Hospital Chun’an Branch, Hangzhou, Zhejiang 311700, China 2 Department of Critical Care Medicine ...
Yi-Bin Wang +17 more
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Fatty Acid Metabolism Provides an Essential Survival Signal in OxPhos and BCR DLBCL Cells
BiomedicinesBackgroung/objectives: Diffuse large B-cell lymphoma (DLBCL) is the most frequent subtype of malignant lymphoma and is a heterogeneous disease with various gene and chromosomal abnormalities.
Aurélie Montagne +7 more
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The levels of NF-κB p50 and NF-κB p65 play a role in thyroid carcinoma malignancy in vivo
Journal of International Medical Research, 2018 Background To investigate the relationship between the levels of nuclear factor (NF)-κB p50 and NF-κB p65 and tumour characteristics in patients with thyroid carcinoma.
Fei Le +4 more
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Loss of NF-κB p50 function synergistically augments microglial priming in the middle-aged brain
Journal of Neuroinflammation, 2019 Background While NF-κB p50 function is impaired in central nervous system disease, aging in non-CNS tissues, and response to reactive oxygen species, the role of NF-κB p50 in aging-associated microglial pro-inflammatory priming is poorly understood ...
Thomas Taetzsch +4 more
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A High-Content RNAi Screen Identifies Ubiquitin Modifiers That Regulate TNF-Dependent Nuclear Accumulation of NF-κB [PDF]
Frontiers in Immunology, 2014 The mammalian tumor necrosis factor (TNF) cytokine is a central mediator of inflammatory events. Recent studies revealed a number of complex and sophisticated interactions between the TNF pathway and the enzymatic activities encoded by ubiquitin ligases and deubiquitylation enzymes.
Brittany eFraser +5 more
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