Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway. [PDF]
, 2020 Low doses of antibiotics are ubiquitous in the marine environment and may exert negative effects on non-target aquatic organisms. Using primary macrophages of common carp, we investigated the mechanisms of action following exposure to several common ...
Chen, Qiqing +8 more
core
β-Arrestin 1 is required for endothelin-1-induced NF-κB activation in ovarian cancer cells [PDF]
, 2014 Aims In epithelial ovarian cancer (EOC), activation of endothelin-1 (ET-1)/endothelin A receptor (ETAR) signalling is linked to many tumor promoting effects, such as proliferation, angiogenesis, invasion and metastasis. These effects are dependent by the
Bagnato, Anna +6 more
core +1 more source
The NF-κB RelA Transcription Factor Is Critical for Regulatory T Cell Activation and Stability
Frontiers in Immunology, 2019 Regulatory T cells (Tregs) play a major role in immune homeostasis and in the prevention of autoimmune diseases. It has been shown that c-Rel is critical in Treg thymic differentiation, but little is known on the role of NF-κB on mature Treg biology.
Emilie Ronin +10 more
doaj +1 more source
, 2019 Additional file 1. Assessment of inflammation due to cold stress.
Cai, Jiayi +4 more
openaire +1 more source
Jurnal Kedokteran Brawijaya, 2013 Resitance  to  steroid  therapy  is  a  poor  prognosis  sign  for  nephrotic  syndrome,  but  this  mechanism is  still unclear. NF-κB has been reported to affect the glucocorticoid at the T cell through the transrepression in  the glucocorticoid  receptor .  Until  know,  this  study  was  still  limited.  The  aim  of Â
Brigitta Ida Rv Corebima +2 more
openaire +2 more sources
Inhibition of oncogenic transcription factor REL by the natural product derivative calafianin monomer 101 induces proliferation arrest and apoptosis in human B-lymphoma cell lines [PDF]
, 2015 Increased activity of transcription factor NF-κB has been implicated in many B-cell lymphomas. We investigated effects of synthetic compound calafianin monomer (CM101) on biochemical and biological properties of NF-κB.
Chennamadhavuni, Spandan +4 more
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Nucleo-cytoplasmic trafficking of TRIM8, a novel oncogene, is involved in positive regulation of TNF induced NF-κB pathway. [PDF]
PLoS ONE, 2012 TNF induced nuclear factor kappa B (NF-κB) is one of the central signaling pathways that plays a critical role in carcinogenesis and inflammatory diseases.
Dhanendra Tomar +5 more
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance The cGAS-STING pathway is important for immune defense against infection and cancer. STING activation triggers multiple signaling cascades leading to activation of IRF3, NF-κB, and autophagy.
S. Yum +3 more
semanticscholar +1 more source
Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation [PDF]
Frontiers in Genetics, 2014 Cardiovascular diseases such as atherosclerosis are one of the leading causes of morbidity and mortality worldwide. The clinical manifestations of atherosclerosis, which include heart attack and stroke, occur several decades after initiation of the disease and become more severe with age.
Nadiya Khyzha +9 more
openaire +4 more sources
The DNA damage response promotes Polyomavirus JC infection by nucleus to cytoplasm NF-Kappa B activation. [PDF]
, 2017 Background: Infection of glial cells by human neurotropic polyomavirus JC (JCV), the causative agent of the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), rapidly inflicts damage to cellular DNA.
Bellizzi, Anna +5 more
core +1 more source