Scientific Reports, 2017 Transcription factor NF-κB plays a central role in immunity from fruit flies to humans, and NF-κB activity is altered in many human diseases. To investigate a role for NF-κB in immunity and disease on a broader evolutionary scale we have characterized NF-
Katelyn M. Mansfield +11 more
doaj +1 more source
Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism
Viruses, 2018 Nuclear factor-κB (NF-κB) is an important transcription factor that induces the expression of antiviral genes and viral genes. NF-κB activation needs the activation of NF-κB upstream molecules, which include receptors, adaptor proteins, NF-κB (IκB ...
Liyao Deng +15 more
doaj +1 more source
New Insights into NF-κB Signaling in Innate Immunity: Focus on Immunometabolic Crosstalks
Biology, 2023 The nuclear factor kappa B (NF-κB) is a family of transcription factors that, beyond their numberless functions in various cell processes, play a pivotal role in regulating immune cell activation.
Dominga Iacobazzi +5 more
doaj +1 more source
The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s Disease
International Journal of Molecular Sciences, 2022 Alzheimer’s Disease (AD) is the most common neurodegenerative disease worldwide, with a high prevalence that is expected to double every 20 years.
Emily Sun +3 more
semanticscholar +1 more source
Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression [PDF]
Nature Communications, 2018 AbstractKnowledge of stromal factors that have a role in the transcriptional regulation of metabolic pathways aside from c-Myc is fundamental to improvements in lymphoma therapy. Using a MYC-inducible human B-cell line, we observed the cooperative activation of STAT3 and NF-κB by IL10 and CpG stimulation.
Feist, M. +18 more
openaire +6 more sources
HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis [PDF]
, 2017 Background Abnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive disorder (HAND) is unclear.
Borjabad, Alejandra +8 more
core +2 more sources
The NF-κB Genomic Landscape in Lymphoblastoid B Cells
Cell Reports, 2014 The nuclear factor κB (NF-κΒ) subunits RelA, RelB, cRel, p50, and p52 are each critical for B cell development and function. To systematically characterize their responses to canonical and noncanonical NF-κB pathway activity, we performed chromatin ...
Bo Zhao +15 more
doaj +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Listeria monocytogenesinfection of Caco-2 human epithelial cells induces activation of transcription factor NF-κB/Rel-like DNA binding activities [PDF]
FEMS Microbiology Letters, 1999 The effect of Listeria monocytogenes infection on the cellular level of transcription factor NF-kappa B in the human epithelia-like cell line Caco-2 was investigated. Infection with L. monocytogenes or treatment with lipoteichoic acid induced the formation of three NF-kappa B-like DNA-protein complexes C1, C2, and C3, which were identified as ...
Franz Fiedler +3 more
openaire +3 more sources
The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus [PDF]
, 2010 Expansion of a polyglutamine (polyQ) tract in the Huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited neurodegenerative disorder.
Baquet +74 more
core +4 more sources