Results 71 to 80 of about 783,867 (386)

The power of microRNA regulation—insights into immunity and metabolism

FEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto, Nicola Manfrini, Stefano Biffo   +2 more
wiley   +1 more source

Plumbagin Suppresses the Invasion of HER2-Overexpressing Breast Cancer Cells through Inhibition of IKKα-Mediated NF-κB Activation. [PDF]

PLoS ONE, 2016
HER2-overexpressing breast cancers account for about 30% of breast cancer occurrences and have been correlated with increased tumor aggressiveness and invasiveness.
Anna Kawiak, Anna Domachowska
doaj   +1 more source

Kombinasi Artemisinin dan Ekstrak Moringa oleifera Menurunkan Ekspresi NF-κB namun Tidak Menurunkan Ekspresi iNOS pada Otak Mencit Diinfeksi Malaria

Jurnal Kedokteran Brawijaya, 2015
Malaria otak merupakan manifestasi tersering dari infeksi malaria berat yang ditandai dengan respon inflamasi berlebih di otak. Untuk mencegah terjadinya resistensi, penggunaan obat antimalaria standar (artemisinin) harus dikombinasikan dengan obat antimalaria lain.
Loeki Enggar Fitri, Mochammad Dalhar, Tinny Endang Endang H, Herpan Syafii Harahap, Eviana Norahmawati   +4 more
openaire   +2 more sources

NF-KB protein purification from bovine spleen: Nucleotide stimulation and binding site specificity [PDF]

, 1988
The activity of the enhancer for the κ immunoglobulin light chain gene critically depends on the presence in the nucleus of the NF-κB protein. We purified NF-κB over 50,000-fold and identified two protein species, 42 and 44 kDa, that could be eluted and ...
Baltimore, David, Gifford, Ann, Kuang, Anna, Lenardo, Michael J.   +3 more
core  

Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders [PDF]

, 2012
Nuclear factor κB (NF-κB) is a transcription factor that regulates various aspects of immune response, cell death, and differentiation as well as cancer.
Belitsky, Chen, Chenoweth, Dervan, Edelson, Eriksson, F. Yang, Gilmore, Gilmore, Grivennikov, Hsu, J. A. Raskatov, J. L. Meier, J. W. Puckett, Kannabiran, Karin, Kawahara, Kielkopf, Kunsch, Lam, Llorca, Matsuda, Nickols, P. B. Dervan, P. Ramakrishnan, Schneiderman, Sen, Sprengers, Trapnell, Vereecke, White   +30 more
core   +2 more sources

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

Cellular heterogeneity in TNF/TNFR1 signalling: live cell imaging of cell fate decisions in single cells

Cell Death and Disease
Cellular responses to TNF are inherently heterogeneous within an isogenic cell population and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF-κB and MAPK signalling pathways but may also trigger apoptosis and ...
Marcus K. Preedy, Michael R. H. White, Vinay Tergaonkar   +2 more
doaj   +1 more source

NF- κB Essential Modulator Deficiency Leading to Disseminated Cutaneous Atypical Mycobacteria

Mediterranean Journal of Hematology and Infectious Diseases, 2014
NF- κB essential modulator (NEMO) is a kinase integral to the macrophage TNF-α pathway, which leads to the intracellular destruction of Mycobacteria species.
Jonathan Braue, Vagishwari Murugesan, Steven Holland, Nishit Patel, Eknath Naik, Jennifer Leiding, Abraham Tareq Yacoub, Carlos N Prieto-Granada, John Norman Greene   +8 more
doaj   +1 more source

NF-κB in biology and targeted therapy: new insights and translational implications

Signal Transduction and Targeted Therapy
NF-κB signaling has been discovered for nearly 40 years. Initially, NF-κB signaling was identified as a pivotal pathway in mediating inflammatory responses.
Qing Guo, Yizi Jin, Xinyu Chen, Xiaomin Ye, Xin Shen, Mingxi Lin, C. Zeng, Teng Zhou, Jian Zhang   +8 more
semanticscholar   +1 more source

NF-κB: At the Borders of Autoimmunity and Inflammation

Frontiers in Immunology, 2021
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory response.
L. Barnabei, E. Laplantine, William Mbongo, F. Rieux-Laucat, R. Weil   +4 more
semanticscholar   +1 more source