Arthritis Care &Research, Accepted Article.Objective A leading cause of death among scleroderma (SSc) patients, interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M Padilla +13 more
wiley +1 more source
NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration
Frontiers in Immunology, 2019 The nuclear factor-κB (NF-κB) signaling pathway is one of the best understood immune-related pathways thanks to almost four decades of intense research.
Michael G. Dorrington, I. Fraser
semanticscholar +1 more source
Relationship between TLR4 and NF-κB p65 protein expressions and clinical radiosensitivity of patients with esophageal squamous cell carcinoma [PDF]
, 1969 Hua Tang +6 more
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The impact of astrocytic NF-κB on healthy and Alzheimer’s disease brains
Scientific ReportsAstrocytes play a role in healthy cognitive function and Alzheimer’s disease (AD). The transcriptional factor nuclear factor-κB (NF-κB) drives astrocyte diversity, but the mechanisms are not fully understood.
Tee Jong Huat +11 more
doaj +1 more source
NF-kappaB signaling pathways in Neurological inflammation: A mini review
Frontiers in Molecular Neuroscience, 2015 The NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells) transcription factor family is a pleiotropic regulator of many cellular signaling pathways, providing a mechanism for the cells in response to a wide variety of stimuli linking to ...
Ruey-Horng eShih +2 more
doaj +1 more source
Activation of NF‐κB Signaling by Optogenetic Clustering of IKKα and β
Advanced Biology, EarlyView.This study presents an optogenetic approach for graded clustering of eGFP‐fused proteins using an eGFP‐specific nanobody and engineered Cryptochrome 2 variants. The method enables potent, reversible activation of NF‐κB signaling via endogenous pathways, as confirmed by RNA sequencing. This versatile system provides a spatially and temporally controlled
Alexandra Anna Maria Fischer +8 more
wiley +1 more source
Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis
Frontiers in Immunology, 2019 The transcription factor NF-κB is a central mediator of inflammation with multiple links to thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types within the vasculature and the circulation that are involved in ...
M. Mussbacher +10 more
semanticscholar +1 more source
Sequential Induction of NF-κB/Rel Family Proteins during B-Cell Terminal Differentiation [PDF]
, 1994 Hsiou‐Chi Liou +3 more
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Real-Time Monitoring of Nuclear Factor κB Activity in Cultured Cells and in Animal Models
Molecular Imaging, 2009 Nuclear factor κB (NF-κB) is a transcription factor that plays a major role in many human disorders, including immune diseases and cancer. We designed a reporter system based on NF-κB responsive promoter elements driving expression of the secreted ...
Christian E. Badr +5 more
doaj +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source