Results 41 to 50 of about 456,853 (317)

A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway. [PDF]

, 2011
The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown ...
Bäumler, Andreas J, Keestra, A Marijke, Kim, Anita, Klein-Douwel, Daisy, Tsolis, Renée M, Winter, Maria G, Winter, Sebastian E, Xavier, Mariana N   +7 more
core   +2 more sources

Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development [PDF]

, 2017
In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes.
Brennan, Joseph J., Gilmore, Thomas D., Matthews, Bryan J., Messerschmidt, Jonathan L., Reynoso, Marinaliz, Williams, Leah M.   +5 more
core   +1 more source

Human Bocavirus NS1 and NS1-70 Proteins Inhibit TNF-α-Mediated Activation of NF-κB by targeting p65. [PDF]

, 2016
Human bocavirus (HBoV), a parvovirus, is a single-stranded DNA etiologic agent causing lower respiratory tract infections in young children worldwide.
A Christensen, A Zhou, AY Chen, B Huang, ET Martin, F Mercurio, H Lukkarinen, HL Luo, J Hiscott, J Napetschnig, J Shen, KA Park, L Unterholzner, L Verstrepen, LF Chen, M Coiras, M Meriluoto, M Severa, MG Santoro, MS Hayden, N Edner, ND Perkins, Q Huang, R Dijkman, RE Randall, RN Silk, RW Korner, S Ghosh, SF Cotmore, T Allander, T Allander, T Lu, T Ursic, TD Gilmore, TE Morrison, W Shen, X Li, XF Deng, Y Hirose, Z Zheng, ZF Zhang   +40 more
core   +1 more source

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

Frontiers in Immunology, 2016
Besides its important role in embryonic development and homeostatic self-renewal in adult tissues, Wnt/β-catenin signaling exerts both anti-inflammatory and proinflammatory functions. This is, at least partially, due to either repressing or enhancing the
Bin Ma, M. Hottiger
semanticscholar   +1 more source

Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF-κB signaling pathway

Oncology Report, 2020
Breast cancer which is the most common type of diagnosed cancer among women worldwide possesses metastatic potential, multi-drug resistance, and high mortality.
A. Zeng, Xin Liang, Shaomi Zhu, Chi Liu, Shu Wang, Qinxiu Zhang, Junning Zhao, Linjiang Song   +7 more
semanticscholar   +1 more source

Evidence linking exposure of fish primary macrophages to antibiotics activates the NF-kB pathway. [PDF]

, 2020
Low doses of antibiotics are ubiquitous in the marine environment and may exert negative effects on non-target aquatic organisms. Using primary macrophages of common carp, we investigated the mechanisms of action following exposure to several common ...
Chen, Qiqing, Fang, Meijuan, Greer, Justin, Hu, Jiaqi, Magnuson, Jason T, Qiu, Wenhui, Schlenk, Daniel, Yang, Ming, Zheng, Chunmiao   +8 more
core  

Regulation of autophagy by the nuclear factor κB signaling pathway in the hippocampus of rats with sepsis [PDF]

, 2015
BACKGROUND: Sepsis with brain dysfunction has contributed to an increase risk of morbidity and mortality. In its pathophysiology, both autophagy and nuclear factor κB (NF-κB) have been suggested to play important roles.
DeZhi Mu, FengYan Zhao, HuaFeng Li, XiHong Li, Yi Qu, YunJie Su   +5 more
core   +1 more source

Epigenetically upregulated oncoprotein PLCE1 drives esophageal carcinoma angiogenesis and proliferation via activating the PI-PLCε-NF-κB signaling pathway and VEGF-C/ Bcl-2 expression

Molecular Cancer, 2019
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies. Neovascularization during tumorigenesis supplies oxygen and nutrients to proliferative tumor cells, and serves as a conduit for migration.
Yunzhao Chen, Dan Wang, Hao-ran Peng, Xi Chen, Xueping Han, Jie Yu, Wenjie Wang, L. Liang, Zheng Liu, Yi Zheng, Jianming Hu, Lan Yang, Jun Li, Hong Zhou, Xiao-bin Cui, Feng Li   +15 more
semanticscholar   +1 more source

Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE/NF-κB signaling pathway in vivo and in vitro

Journal of Neuroinflammation, 2020
Background Glial activation and neuroinflammation play a crucial role in the pathogenesis and development of Alzheimer’s disease (AD). The receptor for advanced glycation end products (RAGE)-mediated signaling pathway is related to amyloid beta (Aβ ...
Bo Ding, Chengheng Lin, Qian Liu, Yingying He, John Bosco Ruganzu, Hui Jin, Xiaoqian Peng, Shengfeng Ji, Yan-bing Ma, Weina Yang   +9 more
semanticscholar   +1 more source

HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-κB pathway in a transcription-independent manner [PDF]

, 2016
HOX proteins define a family of key transcription factors regulating animal embryogenesis. HOX genes have also been linked to oncogenesis and HOXA1 has been described to be active in several cancers, including breast cancer.
Draime, A. (Amandine), Geerts, D. (Dirk), Lambert, B. (Barbara), Nguyen, N. (Nathan), Renard, P. (Patricia), Rezsöhazy, R. (René), Taminiau, A. (Arnaud), Tys, J. (Janne), Vandeputte, J. (Julie)   +8 more
core   +4 more sources