Single TNFalpha trimers mediating NF-kappaB activation: stochastic robustness of NF-kappaB signaling. [PDF]
BMC bioinformatics, 2008 The NF-kappaB regulatory network controls innate immune response by transducing variety of pathogen-derived and cytokine stimuli into well defined single-cell gene regulatory events.We analyze the network by means of the model combining a deterministic description for molecular species with large cellular concentrations with two classes of stochastic ...
Lipniacki, Tomasz +4 more
openaire +4 more sources
The type III secretion effector NleE inhibits NF-kappaB activation. [PDF]
PLoS Pathogens, 2010 The complex host-pathogen interplay involves the recognition of the pathogen by the host's innate immune system and countermeasures taken by the pathogen. Detection of invading bacteria by the host leads to rapid activation of the transcription factor NF-
Chen Nadler +10 more
doaj +1 more source
HIF-1β Positively Regulates NF-κB Activity via Direct Control of TRAF6 [PDF]
, 2020 NF-B signalling is crucial for cellular responses to inflammation but has also been associated with the hypoxia response. NF-B and HIF transcription factors possess an intense molecular crosstalk.
Batie, Michael +4 more
core +2 more sources
Transcription factor NF-kappaB is transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons. [PDF]
PLoS ONE, 2007 Long-term changes in synaptic plasticity require gene transcription, indicating that signals generated at the synapse must be transported to the nucleus. Synaptic activation of hippocampal neurons is known to trigger retrograde transport of transcription
Ilja Mikenberg +4 more
doaj +1 more source
Addressing reported pro-apoptotic functions of NF-kappaB: targeted inhibition of canonical NF-kappaB enhances the apoptotic effects of doxorubicin. [PDF]
PLoS ONE, 2009 The ability of the transcription factor NF-kappaB to upregulate anti-apoptotic proteins has been linked to the chemoresistance of solid tumors to standard chemotherapy. In contrast, recent studies have proposed that, in response to doxorubicin, NF-kappaB
Brian K Bednarski +2 more
doaj +1 more source
Modulation of the NF-kappaB pathway by Bordetella pertussis filamentous hemagglutinin. [PDF]
PLoS ONE, 2008 Filamentous hemagglutinin (FHA) is a cell-associated and secreted adhesin produced by Bordetella pertussis with pro-apoptotic and pro-inflammatory activity in host cells.
Tzvia Abramson +2 more
doaj +1 more source
Two modes of transcriptional activation at native promoters by NF-kappaB p65. [PDF]
PLoS Biology, 2009 The NF-kappaB family of transcription factors is crucial for the expression of multiple genes involved in cell survival, proliferation, differentiation, and inflammation.
Dominic van Essen +3 more
doaj +1 more source
Co-regulation of NF-kappaB and inflammasome-mediated inflammatory responses by myxoma virus pyrin domain-containing protein M013. [PDF]
PLoS Pathogens, 2009 NF-kappaB and inflammasomes both play central roles in orchestrating anti-pathogen responses by rapidly inducing a variety of early-response cytokines and chemokines following infection.
Masmudur M Rahman +4 more
doaj +1 more source
TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy. [PDF]
PLoS ONE, 2010 Classical NF-kappaB signaling functions as a negative regulator of skeletal myogenesis through potentially multiple mechanisms. The inhibitory actions of TNFalpha on skeletal muscle differentiation are mediated in part through sustained NF-kappaB ...
Swarnali Acharyya +9 more
doaj +1 more source
HIV gp120 induces, NF-kappaB dependent, HIV replication that requires procaspase 8. [PDF]
PLoS ONE, 2009 HIV envelope glycoprotein gp120 causes cellular activation resulting in anergy, apoptosis, proinflammatory cytokine production, and through an unknown mechanism, enhanced HIV replication.We describe that the signals which promote apoptosis are also ...
Gary D Bren +4 more
doaj +1 more source