PLoS ONE, 2009 Optineurin is a ubiquitously expressed multifunctional cytoplasmic protein encoded by OPTN gene. The expression of optineurin is induced by various cytokines.
Cherukuri Sudhakar +3 more
doaj +1 more source
Two alleles of NF-kappaB in the sea anemone Nematostella vectensis are widely dispersed in nature and encode proteins with distinct activities. [PDF]
PLoS ONE, 2009 NF-kappaB is an evolutionarily conserved transcription factor that controls the expression of genes involved in many key organismal processes, including innate immunity, development, and stress responses. NF-kappaB proteins contain a highly conserved DNA-
James C Sullivan +6 more
doaj +1 more source
Infected cell killing by HIV-1 protease promotes NF-kappaB dependent HIV-1 replication. [PDF]
PLoS ONE, 2008 Acute HIV-1 infection of CD4 T cells often results in apoptotic death of infected cells, yet it is unclear what evolutionary advantage this offers to HIV-1.
Gary D Bren +6 more
doaj +1 more source
Expanding the substantial interactome of NEMO using protein microarrays. [PDF]
PLoS ONE, 2010 Signal transduction by the NF-kappaB pathway is a key regulator of a host of cellular responses to extracellular and intracellular messages. The NEMO adaptor protein lies at the top of this pathway and serves as a molecular conduit, connecting signals ...
Beau J Fenner +2 more
doaj +1 more source
Peroxynitrite is a potent inhibitor of NF-{kappa}B activation triggered by inflammatory stimuli in cardiac and endothelial cell lines. [PDF]
, 2005 Peroxynitrite is a potent oxidant and nitrating species proposed as a direct effector of myocardial damage in numerous cardiac pathologies. Whether peroxynitrite also acts indirectly, by modulating cell signal transduction in the myocardium, has not been
Feihl, F. +7 more
core +2 more sources
Tomato lycopene extract prevents lipopolysaccharide-induced NF-kappaB signaling but worsens dextran sulfate sodium-induced colitis in NF-kappaBEGFP mice. [PDF]
PLoS ONE, 2009 The impact of tomato lycopene extract (TLE) on intestinal inflammation is currently unknown. We investigated the effect of TLE on lipopolysaccharide (LPS)-induced innate signaling and experimental colitis.Mice were fed a diet containing 0.5 and 2% TLE or
Young-Eun Joo +6 more
doaj +1 more source
RelB-dependent stromal cells promote T-cell leukemogenesis. [PDF]
PLoS ONE, 2008 BACKGROUND: The Rel/NF-kappaB transcription factors are often activated in solid or hematological malignancies. In most cases, NF-kappaB activation is found in malignant cells and results from activation of the canonical NF-kappaB pathway, leading to ...
Nuno R dos Santos +7 more
doaj +1 more source
Antineoplastic effect of decoy oligonucleotide derived from MGMT enhancer. [PDF]
PLoS ONE, 2014 Silencing of O(6)-methylguanine-DNA-methyltransferase (MGMT) in tumors, mainly through promoter methylation, correlates with a better therapeutic response and with increased survival.
Tamar Canello +5 more
doaj +1 more source
Suppression of nuclear factor-κB activity in macrophages by chylomicron remnants: modulation by the fatty acid composition of the particles [PDF]
, 2009 Current evidence indicates that chylomicron remnants (CMR) induce macrophage foam cell formation, an early event in atherosclerosis. Inflammation also plays a part in atherogenesis and the transcription factor nuclear factor-kappaB (NF-kappaB) has been ...
De Pascale, C. +9 more
core +1 more source
Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. [PDF]
, 2007 Humans and mice lacking functional caspase-8 in T cells manifest a profound immunodeficiency syndrome due to defective T cell antigen receptor (TCR)-induced NF-kappaB signaling and proliferation.
Budd, R.C. +11 more
core +1 more source