PLoS Pathogens, 2009 Nuclear factor (NF)-kappaB is a major survival pathway engaged by the Human T-Lymphotropic Virus type 1 (HTLV-1) Tax protein. Tax1 activation of NF-kappaB occurs predominantly in the cytoplasm, where Tax1 binds NF-kappaB Essential Modulator (NEMO ...
Chloé Journo +11 more
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IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway. [PDF]
PLoS ONE, 2010 Activation of the transcription factor NF-kappaB by cytokines is rapid, mediated through the activation of the IKK complex with subsequent phosphorylation and degradation of the inhibitory IkappaB proteins.
Mazhar Adli +3 more
doaj +1 more source
RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells [PDF]
, 2008 The balance between antiapoptotic and proapoptotic proteins of the Bcl-2 family is critical in determining the fate of T cells in response to death stimuli.
A., Annibaldi +7 more
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Expression of wild-type CFTR suppresses NF-kappaB-driven inflammatory signalling. [PDF]
PLoS ONE, 2010 Mutation of the cystic fibrosis transmembrane-conductance regulator (CFTR) causes cystic fibrosis (CF) but not all CF aspects can easily be explained by deficient ion transport.
Mairi J Hunter +5 more
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Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-κB [PDF]
, 2004 11 pages, 9 figures.Aerobic cells adjust the expression of antioxidant enzymes to maintain reactive oxygen species within tolerable levels. In addition, phosphatidylinositol 3 kinase (PI3K) and its downstream protein kinase effector Akt adapt cells to ...
Cuadrado, Antonio +4 more
core +2 more sources
The flavonoid luteolin worsens chemical-induced colitis in NF-kappaB(EGFP) transgenic mice through blockade of NF-kappaB-dependent protective molecules. [PDF]
PLoS ONE, 2007 The flavonoid luteolin has anti-inflammatory properties both in vivo and in vitro. However, the impact of luteolin on experimental models of colitis is unknown.To address the therapeutic impact of luteolin, NF-kappaB(EGFP) transgenic mice were fed a chow
Thomas Karrasch +3 more
doaj +1 more source
7-Ketocholesterol Induces Cell Apoptosis by Activation of Nuclear Factor kappa B in Mouse Macrophages [PDF]
, 2010 We investigated the molecular mechanisms responsible for the induction of apoptosis in mouse monocytic macrophage cell line J774A.1 stimulated by 7-ketocholesterol (7-KC). Cell apoptosis was detected by Annexin V-propidium iodide (PI) staining.
Chi, Yan +11 more
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Memory extinction entails the inhibition of the transcription factor NF-kappaB. [PDF]
PLoS ONE, 2008 In contextual memories, an association between a positive or negative reinforcement and the contextual cues where the reinforcement occurs is formed. The re-exposure to the context without reinforcement can lead to memory extinction or reconsolidation ...
Emiliano Merlo, Arturo Romano
doaj +1 more source
Differential activation of nuclear factor kappa B subunits in a skin dendritic cell line in response to the strong sensitizer 2,4-dinitrofluorobenzene [PDF]
, 2002 Dendritic cell (DC) maturation is essential for the initiation of T-dependent immune responses. Nuclear factor kappa B (NF-kappaB) transcription factors are ubiquitously expressed signalling molecules, known to regulate the transcription of a large ...
Carvalho, AP +5 more
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NF-κB/STAT3/PI3K signaling crosstalk in iMycEμ B lymphoma [PDF]
, 2010 BACKGROUND: Myc is a well known driver of lymphomagenesis, and Myc-activating chromosomal translocation is the recognized hallmark of Burkitt lymphoma, an aggressive form of non-Hodgkin's lymphoma.
Seong-Su Han +8 more
core +2 more sources