Results 61 to 70 of about 99,051 (206)

Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management

Rheumatology &Autoimmunity, EarlyView.
Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley   +1 more source

TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL.

PLoS ONE, 2010
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is known as a "death ligand"-a member of the TNF superfamily that binds to receptors bearing death domains.
Josep Maria Lluis, Ulrich Nachbur, Wendy Diane Cook, Ian Edward Gentle, Donia Moujalled, Maryline Moulin, Wendy Wei-Lynn Wong, Nufail Khan, Diep Chau, Bernard Andrew Callus, James Edward Vince, John Silke, David Lawrence Vaux   +12 more
doaj   +1 more source

Tumor suppressor CYLD acts as a negative regulator for non-typeable Haemophilus influenza-induced inflammation in the middle ear and lung of mice. [PDF]

PLoS ONE, 2007
Non-typeable Haemophilus influenza (NTHi) is an important human pathogen causing respiratory tract infections in both adults and children. NTHi infections are characterized by inflammation, which is mainly mediated by nuclear transcription factor kappaB (
Jae Hyang Lim, Hirofumi Jono, Tomoaki Koga, Chang-Hoon Woo, Hajime Ishinaga, Patricia Bourne, Haodong Xu, Un-Hwan Ha, Haidong Xu, Jian-Dong Li   +9 more
doaj   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Investigation on constitutive IKK activity in the axon initial segment [PDF]

, 2007
Poster presentation: The transcription factor NF-kappaB plays a central role in the development and maintenance of the central nervous system and its constitutive activation in neurons has been repeatedly reported.
Deller, Thomas, König, Hans-Georg, Prehn, Jochen H. M., Schultz, Christian, Schwamborn, Robert   +4 more
core  

Non-classical ProIL-1beta activation during mammary gland infection is pathogen-dependent but caspase-1 independent [PDF]

, 2014
Infection of the mammary gland with live bacteria elicits a pathogen-specific host inflammatory response. To study these host-pathogen interactions wild type mice, NF-kappaB reporter mice as well as caspase-1 and IL-1beta knockout mice were ...
A Ito, B Brand, C Coeshott, C Kebaier, C Riollet, D Demon, D Demon, Dario S. Zamboni, DD Bannerman, Dieter Demon, DJ Hazuda, E Brouillette, E Gonen, EM Ibeagha-Awemu, Evelyne Meyer, F Li, H Carlsen, Harald Carlsen, HW Barkema, J Gunther, J Mehrzad, J Monks, K Demeyere, K Farhat, K Jensen, K Persson-Waller, Koen Breyne, Kristel Demeyere, KW Kim, L Connelly, L Lara-Zárate, M Lamkanfi, M Rinaldi, M Wittmann, MG Stevens, Niek N. Sanders, OC Kousidou, Peter Vandenabeele, RA Black, S Balasubramanian, S Bougarn, S Elazar, S Elazar, S Liu, S Mandard, S Notebaert, S Notebaert, S Notebaert, SK Cool, Steven K. Cool, TC Lin, Tom Vandenberghe, U Meyer-Hoffert, U Schonbeck, W Yang, Wim Van Den Broeck, X Li, YH Schukken   +57 more
core   +5 more sources

Ultrasound in Women's Health: Mechanisms, Applications, and Emerging Opportunities

Advanced Materials, Volume 38, Issue 14, 6 March 2026.
As healthcare moves toward decentralization, ultrasound technologies are evolving from strictly imaging tools in clinical settings into versatile diagnostic and therapeutic platforms, with growing roles addressing women's health needs. This review highlights how ultrasound's underlying physical mechanisms can be harnessed to reduce disparities in women'
Sarah B. Ornellas, Bilal Kizilaslan, Aastha Shah, Jason F. Hou, Yoonsoo Shin, Alejandra Hernandez Moyers, Claudia Lozano, Canan Dagdeviren   +7 more
wiley   +1 more source

Requirement for the NF-kappa B family member Re1A in the development of secondary lymphoid organs [PDF]

, 2002
The transcription factor nuclear factor (NF)-kappaB has been suggested to be a key mediator of the development of lymph nodes and Peyer's patches. However, targeted deletion of NF-kappaB/ Rel family members has not yet corroborated such a function.
Alcamo, Elizabeth, Baltimore, David, Hacohen, Nir, Hynes, Richard O., Rennert, Paul D., Schulte, Leah C.   +5 more
core  

HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study [PDF]

, 2008
BACKGROUND: How HIV-1 enter into the eyes remains obscure. We postulated that HIV-1 Tat protein can alter the expression of specific tight-junction proteins and disturb the blood retinal barrier, and contributes to HIV trafficking into the eyes.
Ling Bai, Zhenping Zhang, Hui Zhang, Xiumei Li, Qiurong Yu, Haotian Lin, Wenhui Yang, MR Robinson, D Gibellini, A Pugliese, F Peruzzi, R Triboulet, JE King, S Doublier, K Lichtenstein, BH Jeng, O Strauss, J Miyoshi, D Landau, M Toborek, WA Banks, H Steuer, M Canki, SH Chiou, T Abe, TA Bailey, H Xu, IE Andras, TO Price, ME Hartnett, S Mennel, T Abe, AB Brantsaeter, AA Davis, M Hornof, M Mannerstrom, K Turksen, J Miyoshi, CC Bridges, H Pu, JC Li, E Toschi, N Li, K Liu, K Chen, HN Yu, LM Williams   +46 more
core   +2 more sources

Bmi-1 promotes the aggressiveness of glioma via activating the NF-kappaB/MMP-9 signaling pathway

BMC Cancer, 2012
Background The prognosis of human glioma is poor, and the highly invasive nature of the disease represents a major impediment to current therapeutic modalities. The oncoprotein B-cell-specific Moloney murine leukemia virus integration site 1 protein (Bmi-
Jiang Lili, Wu Jueheng, Yang Yi, Liu Liping, Song Libing, Li Jun, Li Mengfeng   +6 more
doaj   +1 more source