Human Chorionic Gonadotropin Protects Vascular Endothelial Cells from Oxidative Stress by Apoptosis Inhibition, Cell Survival Signalling Activation and Mitochondrial Function Protection. [PDF]
, 2015 Background/Aim: Previous reports have made it hypothetically possible that human chorionic gonadotropin (hCG) could protect against the onset of pregnancy-related pathological conditions by acting as an antioxidant.
Farruggio, Serena +7 more
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Kaohsiung Journal of Medical Sciences, 2014 This study investigates whether endothelin-1 (ET-1) mediates monocrotaline (MCT)-induced pulmonary artery hypertension (PAH) and right ventricular hypertrophy (RVH), and if so, whether the G-protein coupled receptor antagonist KMUP-1 (7-{2-[4-(2 ...
Chung-Pin Liu +6 more
doaj +1 more source
مجله دانشکده پزشکی اصفهان, 2012 Background: Nitric oxide (NO) has beneficial effects on cardiovascular system including improvement of angiogenesis. The aim of this study was to evaluate the effects of L-arginine (the precursor of NO) and L-NG-nitroarginine methyl ester (L-NAME) (NO ...
Majid Khazaei +7 more
doaj
Nitric oxide regulates skeletal muscle fatigue, fiber type, microtubule organization, and mitochondrial ATP synthesis efficiency through cGMP-dependent mechanisms [PDF]
, 2016 Aim: Skeletal muscle nitric oxide–cyclic guanosine monophosphate (NO-cGMP) pathways are impaired in Duchenne and Becker muscular dystrophy partly because of reduced nNOSμ and soluble guanylate cyclase (GC) activity.
Balke, Jordan E +8 more
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Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice [PDF]
, 2010 Background Although it has been largely demonstrated that nitric oxide synthase (NOS), a key enzyme for nitric oxide (NO) production, modulates inflammatory pain, the molecular mechanisms underlying these effects remain to be clarified.
Boettger, Michael K +5 more
core +2 more sources
Journal of FungiMarine-derived fungi are assuming an increasingly central role in the search for natural leading compounds with unique chemical structures and diverse pharmacological properties.
Jiao Xiao +6 more
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Regulation of cytokine gene expression by reactive oxygen and reactive nitrogen intermediates [PDF]
, 1996 Reactive oxygen intermediates (ROI), reactive nitrogen intermediates (RNI), and cytokines are frequent companions at sites of acute inflammation. Previous work has established a clear link between the production of cytokines and the subsequent generation
Remick, Daniel G., Villarete, Lorelie
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Biochemical Assay Optimization and Computational Screening Efforts to Identify Potential LuxS Inhibitors [PDF]
, 2013 Quorum sensing (QS) is a process of coordination of bacterial gene expression in response to cell population. System two QS is regulated by the small signaling molecule autoinducer-2 (AI-2) and is implicated in the infectious behaviors of various ...
Wang, Keeshia Q
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Regulatory Mechanisms in Biosystems, 2018 The processes of effect of L-arginine-L-glutamate on peroxidation and slime-forming function of the stomach cells, the system of antioxidant defense in the blood, liver and brain tissues of rats with experimental pathology of the gastroduodenal zone have
Y. M. Stepanov +5 more
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Gut microbiota-derived trimethylamine N-Oxide: a novel target for the treatment of preeclampsia
Gut MicrobesPre-eclampsia (PE) is the most common complication of pregnancy and seriously threatens the health and safety of the mother and child. Studies have shown that an imbalance in gut microbiota can affect the progression of PE.
Jiayi Wang +8 more
doaj +1 more source