Aging-Associated Liver Sinusoidal Endothelial Cells Dysfunction Aggravates the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease. [PDF]
Aging CellAged rats and human are more susceptible to MASLD‐related liver injury, steatosis, and fibrosis, accompanied by worsening of endothelial dysfunction. The SIRT1/p‐eNOS/NO pathway is involved in aggravated MASLD caused by aging‐related LSECs dysfunction.
Dai Q +5 more
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S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis. [PDF]
, 2017 Studies suggest that a low level of circulating human endothelial progenitor cells (EPCs) is a risk factor for ischemic injury and coronary artery disease (CAD). Consumption of S-allylcysteine (SAC) is known to prevent CAD.
Chao, Che-Yi +7 more
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Leptin Enhances Nitric Oxide Production and Decreases Blood Flow in Rat Skeletal Muscle
European Journal of Biology, 2022 Objective: There are a few studies related to nitric oxide (NO) and leptin interaction in the regulation of physiological events in skeletal muscle. Therefore, the aim of the present study is to investigate the interaction of leptin and NO in response to
Savaş Üstünova +2 more
doaj +1 more source
Role of L-type Ca2+-channels in the vasorelaxing response to finerenone in arteries of human visceral adipose tissue. [PDF]
Physiol RepThe vasoactive response to the nonsteroidal mineralocorticoid receptor antagonist (MRA) finerenone was tested ex vivo in arteries of human visceral adipose tissue (VAT). Finerenone elicited endothelium‐independent vasorelaxation in arteries precontracted with different vasoconstrictors; the steroidal MRA potassium canrenoate, by contrast, did not relax
Schinzari F +5 more
europepmc +2 more sources
Current Issues in Molecular Biology, 2022 We have recently illustrated that nebivolol can inhibit angiotensin II (Ang II)-mediated signaling in cardiomyoblasts; however, to date, the detailed mechanism for the beneficial effects of nebivolol has not been studied.
Rukhsana Gul +2 more
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A key role for peroxynitrite-mediated inhibition of cardiac ERG (Kv11.1) K+ channels in carbon monoxide–induced proarrhythmic early afterdepolarizations [PDF]
, 2017 Exposure to carbon monoxide (CO) causes early afterdepolarization arrhythmias. Previous studies in rats indicated arrhythmias arose due to augmentation of the late Na+ current.
Chris Peers +8 more
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Acidosis potentiates endothelium-dependent vasorelaxation and gap junction communication in the superior mesenteric artery. [PDF]
, 2018 Extracellular pH is an important physiological determinant of vascular tone that is normally maintained within 7.35-7.45. Any change outside this range leads to severe pathological repercussions.
Mohanty, Ipsita +3 more
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Brazilian Journal of Medical and Biological Research, 2016 A relationship between thyroid hormones and the cardiovascular system has been well established in the literature. The present in vitro study aimed to investigate the mechanisms involved in the vasodilator effect produced by the acute application of 10-8–
J. Lozano-Cuenca +6 more
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Overview of Antagonists Used for Determining the Mechanisms of Action Employed by Potential Vasodilators with Their Suggested Signaling Pathways [PDF]
, 2016 This paper is a review on the types of antagonists and the signaling mechanism pathways that have been used to determine the mechanisms of action employed for vasodilation by test compounds.
Ahmad, Mariam +5 more
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Intermedin inhibits norepinephrine-induced contraction of rat seminal vesicle
Asian Pacific Journal of Reproduction, 2014 Objective: To study the effect of inter medin(IMD) on smooth muscle of rat seminal vesicles including the specific receptors and the signal pathways involved. Methods: The contraction of the seminal vesicle in response to norepinephrine (NE) and ADM2/IMD
P.F. Wong, M.P.L. Cheung, O WS, F. Tang
doaj +1 more source