Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy. [PDF]
PLoS ONE, 2013 Maternal undernutrition results in elevated blood pressure (BP) and endothelial dysfunction in adult offspring. However, few studies have investigated interventions during early life to ameliorate the programming of hypertension and vascular disorders ...
Clint Gray +3 more
doaj +1 more source
Reduction–oxidation (redox) system in radiation-induced normal tissue injury: molecular mechanisms and implications in radiation therapeutics [PDF]
, 2018 Every year, millions of cancer patients undergo radiation therapy for treating and destroying abnormal cell growths within normal cell environmental conditions.
Abdollahi, H. +10 more
core +2 more sources
Role of an indole-thiazolidine molecule PPAR pan-agonist and COX inhibitor on inflammation and microcirculatory damage in acute gastric lesions. [PDF]
PLoS ONE, 2013 The present study aimed to show the in vivo mechanisms of action of an indole-thiazolidine molecule peroxisome-proliferator activated receptor pan-agonist (PPAR pan) and cyclooxygenase (COX) inhibitor, LYSO-7, in an ethanol/HCl-induced (Et/HCl) gastric ...
José Roberto Santin +7 more
doaj +1 more source
Oliveria decumbens, a Long‐Neglected Plant with Promising Phytochemical and Biological Properties
Chemistry &Biodiversity, Volume 21, Issue 7, July 2024.Abstract Oliveria decumbens is a folkloric medicinal plant belonging to the Apiaceae family, traditionally utilized to treat various diseases like gastrointestinal disorders, fever, and wounds. This review aims to provide a comprehensive overview of the plant‘s phytochemical composition and biological properties, with potential implications for various
Anahita Boveiri Dehsheikh +4 more
wiley +1 more source
Signalling Mechanisms Underlying Doxorubicin and Nox2 NADPH Oxidase-Induced Cardiomyopathy: Involvement of Mitofusin-2 [PDF]
, 2017 BACKGROUND AND PURPOSE: The anthracycline doxorubicin (DOX), although successful as a first-line cancer treatment, induces cardiotoxicity linked with increased production of myocardial reactive oxygen species (ROS), with Nox2 NADPH oxidase-derived ...
Dunne, Philip D +7 more
core +1 more source
Advanced Science, Volume 11, Issue 21, June 5, 2024.The down‐regulation of THBS1 can destabilize TAK1 via NEDD4‐mediated, K48‐linked TAK1 ubiquitination, resulting in the activation of the necroptosis and DAMPs release in trophoblast cells, thus participating in the pathogenesis of PE. Abstract Preeclampsia (PE) is considered as a disease of placental origin. However, the specific mechanism of placental
Haoyue Hu +15 more
wiley +1 more source
Rat duodenal motility in vitro: Prokinetic effects of DL-homocysteine thiolactone and modulation of nitric oxide mediated inhibition [PDF]
, 2013 Homocysteine is a significant but modifiable risk factor for vascular diseases. As gastrointestinal smooth musculature is similar to blood vessel muscles, we investigated how elevated homocysteine levels affect nitric oxide-mediated ...
Ilić S. +7 more
core +1 more source
Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS. [PDF]
PLoS ONE, 2012 The hormone, relaxin, inhibits aberrant myofibroblast differentiation and collagen deposition by disrupting the TGF-β1/Smad2 axis, via its cognate receptor, Relaxin Family Peptide Receptor 1 (RXFP1), extracellular signal-regulated kinase (ERK)1/2 ...
Bryna Suet Man Chow +5 more
doaj +1 more source
European Journal of Heart Failure, Volume 26, Issue 4, Page 707-729, April 2024.Pulmonary hypertension (PH) associated with left heart failure (LHF) (PH‐LHF) is one of the most common causes of PH. It directly contributes to symptoms and reduced functional capacity and negatively affects right heart function, ultimately leading to a poor prognosis.
Pietro Ameri +39 more
wiley +1 more source
Chronic Kidney Disease Increases Cerebral Microbleeds in Mouse and Man. [PDF]
, 2020 Brain microbleeds are increased in chronic kidney disease (CKD) and their presence increases risk of cognitive decline and stroke. We examined the interaction between CKD and brain microhemorrhages (the neuropathological substrate of microbleeds) in ...
Bangash, Maria +13 more
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