P38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-Uncoupling in Obesity [PDF]
, 2014 Background Endothelial nitric oxide synthase (eNOS)-uncoupling links obesity-associated insulin resistance and type-II diabetes to the increased incidence of cardiovascular disease.
Ming, Xiu-Fen +4 more
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Protective effect of picroside II on myocardial ischemia reperfusion injury in rats
Drug Design, Development and Therapy, 2014 Nan Wu, Wenna Li, Wenqi Shu, Dalin Jia Department of Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, People's Republic of China Abstract: The aim of this study was to determine the effect of picroside II on ...
Wu N, Li W, Shu W, Jia D
doaj
Bixa orellana leaf extract suppresses histamine-induced endothelial hyperpermeability via the PLC-NO-cGMP signaling cascade [PDF]
, 2015 BACKGROUND: Histamine is established as a potent inflammatory mediator and it is known to increased endothelial permeability by promoting gap formation between endothelial cells.
Hoe Siong Chiong +3 more
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Journal of Ginseng Research, 2015 Background: Ginseng belongs to the genus Panax. Its main active ingredients are the ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract.
Noo Ri Hong +5 more
doaj +1 more source
Suppressive effects of Mimosa pudica (L.) constituents on the production of LPS-induced pro-inflammatory mediators [PDF]
, 2014 The present study deals with the isolation of fourteen compounds from the active ethyl acetate (MPE) extract of M. pudica (L.) whole plant and their subsequent evaluation for the nitric oxide (NO), tumor necrosis factor alpha (TNF-α) and interleukin 1 ...
Bhutani, Kamlesh K., Patel, Neeraj K.
core
Divergent cardiac and renal effects of miR-181c-5p inhibition in a rodent heart failure model
Frontiers in Cardiovascular MedicineAimsMiR-181c-5p overexpression associates with heart failure (HF) and cardiac damage, but the underlying pathophysiology remains unclear. This study investigated the effect of miR-181c-5p inhibition on cardiac function and fibrosis in a rodent model of ...
Jente R. A. Boen +13 more
doaj +1 more source
Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion [PDF]
, 2013 Funding Information: Source of funding The study received partial support from FTC (Fundação para a Ciência e a Tecnologia - Portuguese Foundation for Science and Technology) under the project PTDC/DTP-EPI/0207/2012.
Baldi, S. +8 more
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GLIAL HEMICHANNELS: A NEW ROUTE FOR CHEMICAL COMMUNICATION IN BRAIN [PDF]
, 2008 The extracellular neurochemistry determines normal brain function and the faith of neurons after insults such as stroke. This thesis concerns the effect of extracellular events related to intense neuronal stimulation and stroke, i.e.
Stridh, Malin
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Acta Cirúrgica Brasileira, 2009 PURPOSE: Evaluate polymorphonuclear leukocytes (PMN's) and mononuclear cells (MN's) involvement in the Ehrlich´s solid tumor (ET) growth. METHODS: 90 Swiss mice were inoculated with 10(7) tumor cells (sc), distributed in three groups and treated once a ...
Olívia Teixeira Gomes Reis +3 more
doaj +1 more source
Genes and DiseasesThe incidence of heart failure with preserved ejection fraction (HFpEF) increases with the ageing of populations. This study aimed to explore ageing-associated gene signatures in HFpEF to develop new diagnostic biomarkers and provide new insights into ...
Guoxing Li +8 more
doaj +1 more source