Results 91 to 100 of about 60,608 (292)

Evaluation of Acute Exposure to Combustible and Novel Tobacco Products Using an In Vitro Human Airway Organ Tissue Equivalent Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Despite the well‐known risks of tobacco use, tobacco exposure remains a major contributor to morbidity and mortality worldwide. Although cigarette use has declined, the popularity of novel tobacco products (NTPs), such as electronic cigarettes (ECs) and heated tobacco products (HTPs), has increased.
Timothy S. Leach, Steven Albertson, Phillip W. Clapp, Vikram Surendran, Trang Simon, Eric C. Donny, Stephen J. Walker, Anthony Atala, Sean V. Murphy   +8 more
wiley   +1 more source

Nicotinic Acid-Mediated Activation of Both Membrane and Nuclear Receptors towards Therapeutic Glucocorticoid Mimetics for Treating Multiple Sclerosis

PPAR Research, 2009
Acute attacks of multiple sclerosis (MS) are most commonly treated with glucocorticoids, which can provide life-saving albeit only temporary symptomatic relief.
W. Todd Penberthy
doaj   +1 more source

Neutrophil apoptosis mediated by nicotinic acid receptors (GPR109A) [PDF]

, 2007
Ganna Kostylina, Dagmar Simon, Martin F. Fey, Shída Yousefi, Hans‐Uwe Simon   +4 more
openalex   +1 more source

Comparative efficacy of novel bioactive glass versus sodium fluoride toothpaste for dentin hypersensitivity

Journal of Periodontology, EarlyView.
Abstract Background This first‐in‐human clinical study aimed to evaluate the safety and efficacy of a bioglass incorporated in a toothpaste, in reducing dentin hypersensitivity (DH) compared to a sodium fluoride (NaF) toothpaste over a 2‐week period. Methods A double‐blind, randomized, parallel‐arm, proof‐of‐concept clinical trial was conducted with 46
Hatice Hasturk, Daniel Boyd, Kathleen MacDonald‐Parsons, Stephanie Turner‐Cahill, Joon Seong, Nicola West, Heather J. Doucette   +6 more
wiley   +1 more source

Synthesis and Anti-Inflammatory Activity of New Nicotinoyl Amides

Eurasian Chemico-Technological Journal
The article presents the results of a study of the amination reaction of nicotinic acid chlorohydride with amines morpholine, cytisine, and 1-aminoadamantane, which are often used in the search and creation of drugs for respiratory and circulatory ...
O.A. Nurkenov, S.D. Fazylov, Zh.S. Nurmaganbetov, T.M. Seilkhanov, A.Zh. Mendibayeva, S.K. Kabieva, E.M. Satbaeva   +6 more
doaj   +1 more source

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, EarlyView.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

Intracerebroventricularly Administered Nicotine Inhibits Vagally Stimulated Gastric Acid Output in Rats by Activating the Central Sympatho-Adrenal Outflow

, 1987
Kunihiko YOKOTANI, Yasunobu Okuma, Yoshitsugu Osumi   +2 more
openalex   +2 more sources

Effect of nicotinic acid on the survival rate, and neurodegeneration of transgenic Drosophila melanogasterwith overexpression of human APP gene

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2013
Transgenic Drosophila melanogaster lines modeling the main neuromorphological markers of Alzheimer's disease were used to study the neuroprotective properties of nicotinic acid.
O. I. Bolshakova, D. I. Rodin, S. I. Timoshenko, E. M. Latypova, S. V. Sarantseva   +4 more
doaj  

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Efficient production of 6-hydroxynicotinic acid by newly isolated Pseudomonas poae

Electronic Journal of Biotechnology
Background: Nicotinic acid dehydrogenase possesses the capability to convert nicotinic acid into 6-hydroxynicotinic acid, a compound of significant research value as a pharmaceutical intermediate.
Yi Li, Jiacheng Tang, Kaixiang Xin, Zongda Chen, Lele Zhao, Yifan Zhao, Yinbiao Xu, Pei Zhou, Yang Sun, Yupeng Liu, Hua Li   +10 more
doaj   +1 more source