Results 11 to 20 of about 11,273 (151)

Dimethyloxonium and Methoxy Derivatives of nido-Carborane and Metal Complexes Thereof [PDF]

Inorganics, 2019
9-Dimethyloxonium, 10-dimethyloxonium, 9-methoxy and 10-methoxy derivatives of nido-carborane (9-Me2O-7,8-C2B9H11, 10-Me2O-7,8-C2B9H11, [9-MeO-7,8-C2B9H11]−, and [10-MeO-7,8-C2B9H11]−, respectively) were prepared by the reaction of the parent
Marina Yu. Stogniy, Svetlana A. Erokhina, Irina D. Kosenko, Andrey A. Semioshkin, Igor B. Sivaev   +4 more
doaj   +2 more sources

An Approach Toward Radioiodination and Radiopharmacological Evaluation of a Carborane-Containing Analog of Indomethacin [PDF]

Molecules
Dicarbadodecaboranes (12) (carboranes) are versatile molecular building blocks with unique properties, which allow the expansion of classical medicinal-chemical space. To enable single-photon emission computed tomography (SPECT) imaging of cyclooxygenase-
Jonas Schädlich, Christoph Selg, Cathleen Haase-Kohn, Martin Ullrich, Robert Wodtke, Klaus Kopka, Evamarie Hey-Hawkins, Jens Pietzsch, Markus Laube   +8 more
doaj   +2 more sources

Structure-Activity Relationships of closo- and nido-Carborane Erlotinib Analogs: Lipophilicity as a Key Modulator of Anti-Glioma Activity [PDF]

Pharmaceuticals
Background/Objectives: To enhance the anti-glioma activity of erlotinib, we previously developed a series of carborane-based analogs exploiting the concept of three-dimensional bioisosterism.
Belén Dávila, Pablo Vignolo, Martina Silvarrey, Andrés Benítez, Juliana González Schmidt, Carmela de Arteaga Guidotti, María Fernanda García, Hugo Cerecetto, Marcos Couto   +8 more
doaj   +2 more sources

<i>Nido</i>-Carborane Derivatives of (<i>S</i>)-Ornithine and (<i>S</i>)-Lysine as Potential Boron Delivery Agents: Synthesis and In Vitro Evaluation. [PDF]

Int J Mol Sci
Derivatives of natural amino acids are selectively absorbed by many types of tumour cells. This makes the use of amino acids, especially polyfunctional ones, attractive as a basis in the design of low-toxicity agents for targeted boron delivery for boron
Gruzdev DA, Levit GL, Musiyak VV, Telegina AA, Ganebnykh IN, Ezhikova MA, Kodess MI, Solovieva OI, Gusel'nikova TY, Razumov IA, Krasnov VP.   +10 more
europepmc   +2 more sources

Crystal and molecular structures of the nido-carborane anions, 7,9- and 2,9-C2B9H12− [PDF]

Journal of the Chemical Society, Dalton Transactions, 2002
Deboronation of meta-carborane, closo-1,7-C2B10H12, with refluxing piperidine results in the quantitative formation of [(C5H10NH)2H+](nido-7,9-C2B9H12−) whose structure was determined by X-ray diffraction. Heating under vacuum liberates piperidine to give (C5H10NH2+)(nido-7,9-C2B9H12−).
Fox, M. A., Goeta, A. E., Hughes, A. K., Johnson, A. L.   +3 more
openaire   +3 more sources

Nucleophilic Addition Reactions to 10-Acetonitrilium Derivative of nido-Carborane and Intramolecular NH⋯HB Interactions in N-Alkyl Amidines 10-RNHC(Me)=NH-7,8-C₂B₉H₁₁ [PDF]

Molecules
The addition reactions of water, alcohols, and primary and secondary amines to the 10-acetonitrilium derivative of nido-carborane were studied. Hydrolysis of 10-MeC≡N-7,8-C2B9H11 results in iminol 10-MeC(OH)=HN-7,8-C2B9H11, which, on treatment with a ...
Kirill R. Pakholkov, Ekaterina V. Bogdanova, Marina Yu. Stogniy, Kyrill Yu. Suponitsky, Sergey A. Anufriev, Igor B. Sivaev, Vladimir I. Bregadze   +6 more
doaj   +2 more sources

Facile synthesis of closo-nido bis(carborane) and its highly regioselective halogenation [PDF]

Journal of Organometallic Chemistry, 2016
1,1’-Bis(ortho-carborane) undergoes mild deboronation in solution in the presence of water with formation of the [7-(1′,2′-closo-C2B10H11-1′-)-7,8-nido-C2B9H11]- (1) anion.
Igor B Sivaev, Kyrill Yu Suponitsky, Vladimir I Bregadze   +2 more
exaly   +2 more sources

Nido-carborane encapsulated by BODIPY zwitterionic polymers: Synthesis, photophysical properties and cell imaging

Journal of Saudi Chemical Society, 2021
Carborane encapsulation was visualized by using fluoroboropyrrole (BODIPY) zwitterionic polymer as fluorescence marker. Firstly, a water-soluble fluorescent probe carrier was prepared by combining the BODIPY derivatives with poly (carboxybetaine ...
Chen Shao, Guangchang Lian, Guofan Jin
doaj   +2 more sources

Dicarba-closo-dodecaborane(12) derivatives of phosphonium salts: easy formation of nido-carborane phosphonium zwitterions [PDF]

Dalton Transactions, 2007
The first examples of arylphosphonium salts containing a dicarba-closo-dodecaborane(12) (closo-carborane) are reported; in contrast to the 1,12-carborane derivative, the 1,2- and 1,7-isomers undergo a facile deboronation reaction in polar solvents to afford the corresponding nido-carborane phosphonium zwitterions.
Ioppolo, Joseph A., Clegg, Jack K., Rendina, Louis M.   +2 more
openaire   +8 more sources

Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential [PDF]

Scientific Reports
In this study, we investigated a novel anti-cancer drug design approach by revisiting diclofenac-based carborane-substituted prodrugs. The redesigned compounds combine the robust carborane scaffold with the oxindole framework, resulting in four carborane-
Christoph Selg, Vuk Gordić, Tamara Krajnović, Antonio Buzharevski, Markus Laube, Aleksandr Kazimir, Peter Lönnecke, Mara Wolniewicz, Menyhárt B. Sárosi, Jonas Schädlich, Jens Pietzsch, Sanja Mijatović, Danijela Maksimović-Ivanić, Evamarie Hey-Hawkins   +13 more
doaj   +2 more sources