Journal of Saudi Chemical Society, 2021 Carborane encapsulation was visualized by using fluoroboropyrrole (BODIPY) zwitterionic polymer as fluorescence marker. Firstly, a water-soluble fluorescent probe carrier was prepared by combining the BODIPY derivatives with poly (carboxybetaine ...
Chen Shao, Guangchang Lian, Guofan Jin
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Dicarba-closo-dodecaborane(12) derivatives of phosphonium salts: easy formation of nido-carborane phosphonium zwitterions [PDF]
Dalton Transactions, 2007 The first examples of arylphosphonium salts containing a dicarba-closo-dodecaborane(12) (closo-carborane) are reported; in contrast to the 1,12-carborane derivative, the 1,2- and 1,7-isomers undergo a facile deboronation reaction in polar solvents to afford the corresponding nido-carborane phosphonium zwitterions.
Ioppolo, Joseph A. +2 more
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Development of Carborane-Based Halogenated Naphthyridinone-Analogues as Cannabinoid Receptor Type 2 (CB<sub>2</sub>R) Ligands. [PDF]
ChemMedChemThere is no suitable radioligand for positron emission tomography imaging of CB2R overexpression for routine clinical usage. Herein, the synthesis, characterization, binding affinity, and docking studies of carborane‐based halo‐substituted naphthyridinone derivatives as CB2R ligands are presented.
Ueberham L +4 more
europepmc +2 more sources
Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents. [PDF]
ChemistryThis review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Selg C, Hey-Hawkins E.
europepmc +2 more sources
nido-carborane conjugates with ibuprofen, flurbiprofen and fenoprofen: synthesis, characterization, COX inhibition potential and anticancer activity [PDF]
Journal of Inorganic BiochemistryThe search for novel anticancer drugs with reduced side effects and innovative therapeutic approaches remains a significant challenge. Non-steroidal anti-inflammatory drugs (NSAIDs), known to inhibit cyclooxygenase (COX) - an enzyme overexpressed in certain tumors - offer a promising avenue for cancer therapy.
Sonam, S. +8 more
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Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential. [PDF]
Sci RepIn this study, we investigated a novel anti-cancer drug design approach by revisiting diclofenac-based carborane-substituted prodrugs. The redesigned compounds combine the robust carborane scaffold with the oxindole framework, resulting in four carborane-
Selg C +13 more
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Nitrogen-Doped Borane Cluster Network for High-Performance Supercapacitors Under Universal pH Conditions. [PDF]
ChemSusChemNitrogen‐doped borane cluster network was prepared as a porous electrode material, featuring 1–2 nm micropores and specific surface area up to 626 m2 g−1. It delivers outstanding supercapacitor performance, reaching 607 F g−1 in a three‐electrode configuration and 354 F g−1 in an asymmetric supercapacitor device.
Udnoor A +8 more
europepmc +2 more sources
Boron-10 carriers and their applications in boron neutron capture therapy. [PDF]
Precis Radiat OncolSummary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Tang D +7 more
europepmc +2 more sources
<i>Nido</i>-Carborane Derivatives of (<i>S</i>)-Ornithine and (<i>S</i>)-Lysine as Potential Boron Delivery Agents: Synthesis and In Vitro Evaluation. [PDF]
Int J Mol SciDerivatives of natural amino acids are selectively absorbed by many types of tumour cells. This makes the use of amino acids, especially polyfunctional ones, attractive as a basis in the design of low-toxicity agents for targeted boron delivery for boron
Gruzdev DA +10 more
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Carboranes as unique pharmacophores in antitumor medicinal chemistry
Molecular Therapy: Oncolytics, 2022 Carborane is a carbon-boron molecular cluster that can be viewed as a 3D analog of benzene. It features special physical and chemical properties, and thus has the potential to serve as a new type of pharmacophore for drug design and discovery.
Yu Chen +10 more
doaj +1 more source