Results 21 to 30 of about 11,276 (152)

Dicarba-closo-dodecaborane(12) derivatives of phosphonium salts: easy formation of nido-carborane phosphonium zwitterions [PDF]

Dalton Transactions, 2007
The first examples of arylphosphonium salts containing a dicarba-closo-dodecaborane(12) (closo-carborane) are reported; in contrast to the 1,12-carborane derivative, the 1,2- and 1,7-isomers undergo a facile deboronation reaction in polar solvents to afford the corresponding nido-carborane phosphonium zwitterions.
Ioppolo, Joseph A., Clegg, Jack K., Rendina, Louis M.   +2 more
openaire   +8 more sources

Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential [PDF]

Scientific Reports
In this study, we investigated a novel anti-cancer drug design approach by revisiting diclofenac-based carborane-substituted prodrugs. The redesigned compounds combine the robust carborane scaffold with the oxindole framework, resulting in four carborane-
Christoph Selg, Vuk Gordić, Tamara Krajnović, Antonio Buzharevski, Markus Laube, Aleksandr Kazimir, Peter Lönnecke, Mara Wolniewicz, Menyhárt B. Sárosi, Jonas Schädlich, Jens Pietzsch, Sanja Mijatović, Danijela Maksimović-Ivanić, Evamarie Hey-Hawkins   +13 more
doaj   +2 more sources

Development of Carborane-Based Halogenated Naphthyridinone-Analogues as Cannabinoid Receptor Type 2 (CB₂R) Ligands. [PDF]

ChemMedChem
There is no suitable radioligand for positron emission tomography imaging of CB2R overexpression for routine clinical usage. Herein, the synthesis, characterization, binding affinity, and docking studies of carborane‐based halo‐substituted naphthyridinone derivatives as CB2R ligands are presented.
Ueberham L, Deuther-Conrad W, Lönnecke P, Kazimir A, Hey-Hawkins E.   +4 more
europepmc   +2 more sources

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents. [PDF]

Chemistry
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Selg C, Hey-Hawkins E.
europepmc   +2 more sources

Nitrogen-Doped Borane Cluster Network for High-Performance Supercapacitors Under Universal pH Conditions. [PDF]

ChemSusChem
Nitrogen‐doped borane cluster network was prepared as a porous electrode material, featuring 1–2 nm micropores and specific surface area up to 626 m2 g−1. It delivers outstanding supercapacitor performance, reaching 607 F g−1 in a three‐electrode configuration and 354 F g−1 in an asymmetric supercapacitor device.
Udnoor A, Prabu S, Vinu M, Kloda M, Mahun A, Kobera L, Londesborough MGS, Chiang KY, Demel J.   +8 more
europepmc   +2 more sources

Boron-10 carriers and their applications in boron neutron capture therapy. [PDF]

Precis Radiat Oncol
Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Tang D, Shi M, Mao Z, Chen W, Li X, Zhao XY, Liu Z, Xu X.   +7 more
europepmc   +2 more sources

nido-carborane conjugates with ibuprofen, flurbiprofen and fenoprofen: synthesis, characterization, COX inhibition potential and anticancer activity [PDF]

Journal of Inorganic Biochemistry
The search for novel anticancer drugs with reduced side effects and innovative therapeutic approaches remains a significant challenge. Non-steroidal anti-inflammatory drugs (NSAIDs), known to inhibit cyclooxygenase (COX) - an enzyme overexpressed in certain tumors - offer a promising avenue for cancer therapy.
Sonam, S., Mojić, M., Laube, M., Schädlich, J., Pietzsch, J., Mijatović, S., Maksimović-Ivanić, D., Hey-Hawkins, E., Kaluđerović, G. N.   +8 more
openaire   +4 more sources

Photoinduced Selective B–H Activation of nido-Carboranes [PDF]

Journal of the American Chemical Society
The development of new synthetic methods for B-H bond activation has been an important research area in boron cluster chemistry, which may provide opportunities to broaden the application scope of boron clusters. Herein, we present a new reaction strategy for the direct site-selective B-H functionalization of nido-carboranes initiated by photoinduced ...
Shengwen Xu, Hongjian Zhang, Jingkai Xu, Weiqun Suo, Chang-Sheng Lu, Deshuang Tu, Xingwei Guo, Jordi Poater, Miquel Solà, Hong Yan   +9 more
core   +6 more sources

Electron-donating abilities and luminescence properties of tolane-substituted nido-carboranes [PDF]

New Journal of Chemistry, 2017
The luminescence properties of nido -carborane-substituted tolane derivatives were investigated.
Kenta Nishino, Yasuhiro Morisaki, Kazuo Tanaka, Yoshiki Chujo   +3 more
openaire   +2 more sources

<i>Nido</i>-Carborane Derivatives of (<i>S</i>)-Ornithine and (<i>S</i>)-Lysine as Potential Boron Delivery Agents: Synthesis and In Vitro Evaluation. [PDF]

Int J Mol Sci
Derivatives of natural amino acids are selectively absorbed by many types of tumour cells. This makes the use of amino acids, especially polyfunctional ones, attractive as a basis in the design of low-toxicity agents for targeted boron delivery for boron
Gruzdev DA, Levit GL, Musiyak VV, Telegina AA, Ganebnykh IN, Ezhikova MA, Kodess MI, Solovieva OI, Gusel'nikova TY, Razumov IA, Krasnov VP.   +10 more
europepmc   +2 more sources