Results 31 to 40 of about 19,627 (213)
Frontiers in Oncology, 2021 ObjectiveHypoxia is prevalent in tumors and plays a pivotal role in resistance to chemoradiotherapy. 18F-MISO (18F-labeled fluoromisonidazole) is currently the preferred choice of PET hypoxia tracers in clinical practice, but has severe disadvantages ...
Jing Lu +7 more
doaj +1 more source
The Hepatocellular Hypoxia Criteria:2’Nitroimidazole Effect on Hepatocyte Carbohydrate Metabolizing Enzymes [PDF]
, 2008 Aim: to understand the 2’-nitroimidazole induced hypoxia and liver cell interaction, we proposed a “Hapatocellular Hypoxia Criteria”.
Rakesh Sharma
core +1 more source
Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine
BMEMat, EarlyView.Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo +9 more
wiley +1 more source
The Structure and Activity of Double-Nitroimidazoles. A Mini-Review
Scientia Pharmaceutica, 2018 Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells.
Justyna Żwawiak, Lucjusz Zaprutko
doaj +1 more source
68Ga‐nitroimidazole PET/CT imaging of hypoxia in tuberculosis: A case series
Journal of Medical Radiation Sciences, 2022 Tuberculosis (TB) lesions in humans have been proven to be severely hypoxic with hypoxia leading to latency and dormancy of disease. Dormant TB lesions become less susceptible to standard TB treatment regimens with varying responses to treatment but may ...
Philippa L Bresser +3 more
doaj +1 more source
2-(3-Bromophenyl)imidazo[2,1-b]oxazole
Molbank, 2023 The microwave-assisted reaction of 2-nitroimidazole with 3-bromophenacyl bromide in the presence of potassium carbonate as a base and dimethylformamide as a solvent afforded 2-(3-bromophenyl)imidazo[2,1-b]oxazole.
Ángel Cores +2 more
doaj +1 more source
Management of trypanosomiasis and leishmaniasis [PDF]
, 2012 <p>Background: The current treatments for human African trypanosomiasis (HAT), Chagas disease and leishmaniasis (collectively referred to as the kinetoplastid diseases) are far from ideal but, for some, there has been significant recent progress ...
Alsford +39 more
core +2 more sources
Exploration, EarlyView.A eutectic phase‐change mixture of natural fatty acids was introduced to serve as a gating material for the near‐infrared‐triggered precise release of oxygen and nitroimidazole radiosensitizer in tumors. The stemness of cancer stem‐like cells was shown to be significantly reduced through the delivery of oxygen to deep tumors.
Yuanfang Chen +9 more
wiley +1 more source
Synthesis of N-7-Substituted Purines from Imidazole Precursors
Molecules, 1999 Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen), was
Stanislaw Ostrowski
doaj +1 more source
Nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion
Drug Delivery, 2023 Hepatocellular carcinoma (HCC) is a malignant tumor leading cancer-associated high mortality worldwide. Unfortunately, the most commonly used drug therapeutics not only lack of target ability and efficiency, but also exhibit severe systemic toxicity to ...
Congyi Zhang +8 more
doaj +1 more source