Results 51 to 60 of about 19,627 (213)

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo. [PDF]

, 2014
Spores of some species of the strictly anaerobic bacteria Clostridium naturally target and partially lyse the hypoxic cores of tumors, which tend to be refractory to conventional therapies. The anti-tumor effect can be augmented by engineering strains to
Dubois, L, Ehsaan, M, Heap, JT, Knox, R, Kubiak, AM, Kuehne, SA, Lambin, P, Mellaert, LV, Minton, NP, Paesmans, K, Theys, J   +10 more
core   +4 more sources

Nitroimidazoles for imaging hypoxic myocardium

Journal of Nuclear Cardiology, 1995
A series of radiopharmaceuticals that incorporate nitroimidazole moieties have been synthesized to detect decreased local tissue pO2. In contrast to agents that localize in proportion to perfusion, these agents concentrate in hypoxic tissue. Myocardium with an intracellular pO2 < 3 mm Hg (about 25% of normal), which has lost its contractile ability but
H W, Strauss, A, Nunn, K, Linder
openaire   +2 more sources

A structured, behavioural science approach to the preparation of antimicrobial stewardship interventions for companion animal veterinarians

Veterinary Record, EarlyView.
Abstract Background A structured, behavioural science approach was adopted to develop antimicrobial stewardship interventions in UK first‐opinion companion animal veterinary practice. The objectives were to identify behavioural targets for intervention and to understand how practice contexts influence these behaviours.
Ben Walker, Dan O'Neill, Huw Stacey, Dave Brodbelt   +3 more
wiley   +1 more source

Nitroimidazole-Induced Reversible Neurotoxicity

Indian Journal of Medical Specialities, 2020
The nitroimidazole group of drugs is commonly used in India and worldwide for diarrhea and other indications. People are taking it over the counter for their subsequent problems without consultation, and this is harmful to them on chronic use. Similarly,
Dinesh Chouksey, Amandeep Singh, Nitisha Goyal, Ajoy K. Sodani   +3 more
doaj   +1 more source

Two 1-substituted 4-nitroimidazoles

Acta Crystallographica Section C Crystal Structure Communications, 2001
Crystalline 4-nitro-1-phenylimidazole, C9H7N3O2, (I), and 4'-nitro-1-phenyl-4,1'-biiimidazole, C12H9N5O2, (II), contain C-H...O and C-H...N hydrogen bonds, connecting the molecules into infinite chains. The aromatic fragments in both compounds are nearly planar.
Kubicki, Maciej, Borowiak, Teresa, Suwinski, Jerzy, Wagner, Pawel   +3 more
openaire   +3 more sources

Core Shell Investigation of 2-nitroimidazole [PDF]

Frontiers in Chemistry, 2019
Tunability and selectivity of synchrotron radiation have been used to study the excitation and ionization of 2-nitroimidazole at the C, N, and O K-edges. The combination of a set of different measurements (X-ray photoelectron spectroscopy, near-edge photoabsorption spectroscopy, Resonant Auger electron spectroscopy, and mass spectrometry) and ...
Paola Bolognesi, Vincenzo Carravetta, Luca Sementa, Giovanni Barcaro, Susanna Monti, Preeti Manjari Mishra, Antonella Cartoni, Antonella Cartoni, Mattea C. Castrovilli, Jacopo Chiarinelli, Jacopo Chiarinelli, Sanja Tosic, Bratislav P. Marinkovic, Robert Richter, Lorenzo Avaldi   +14 more
openaire   +6 more sources

Review Article: Classic Bismuth Quadruple Therapy for Helicobacter pylori Infection—Questions Focused on Clinical Practice

Alimentary Pharmacology &Therapeutics, EarlyView.
BQT remains the most effective, safe, and practical regimen for H. pylori eradication, ensuring high cure rates across diverse resistance patterns and clinical settings. ABSTRACT Background Classic bismuth quadruple therapy (BQT)—the combination of a proton pump inhibitor, bismuth, tetracycline, and metronidazole—is a standard regimen for treating ...
Javier P. Gisbert, Pablo Parra, Olga P. Nyssen   +2 more
wiley   +1 more source

Michael-type addition of azoles of broad-scale acidity to methyl acrylate

Beilstein Journal of Organic Chemistry, 2011
An optimisation of Michael-type addition of azole derivatives of broad-scale acidity – ranging from 5.20 to 15.00 pKa units – namely 4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 4(5)-nitroimidazole, 4,5-diphenylimidazole, 4,5-dicyanoimidazole, 2-methyl-
Sławomir Boncel, Kinga Saletra, Barbara Hefczyc, Krzysztof Z. Walczak   +3 more
doaj   +1 more source

Novel 3-nitrotriazole-based amides and carbinols as bifunctional anti-Chagasic agents. [PDF]

, 2015
3-Nitro-1H-1,2,4-triazole-based amides with a linear, rigid core and 3-nitrotriazole-based fluconazole analogs were synthesized as dual functioning antitrypanosomal agents.
Alsford S., Andriani G., Andriani G., Baker N., Benjamín Aguilera-Venegas, Bern C., Buchanan-Kilbey G., Diniz L. d. F., Eric Chatelain, Fabbro D. L., Galina I. Lepesheva, Gautret P., Hall B. S., Hall B. S., Hargrove T. Y., Howard S. Rosenzweig, Jean-Robert Ioset, Keenan M., Lepesheva G. I., Lepesheva G. I., Lepesheva G. I., Lepesheva G. I., Leslie M., Marcel Kaiser, Maria V. Papadopoulou, Molina I., Molyneux D. H., Moraes C. B., Nwaka S., Orhan I., Papadopoulou M. V., Papadopoulou M. V., Papadopoulou M. V., Papadopoulou M. V., Rassi A., Shane R. Wilkinson, Stewart B. H., Urbina J. A., Urbina J. A., Villalta F., Wilkinson S. R., Wilkinson S. R., William D. Bloomer   +42 more
core   +3 more sources

Genotoxicity profile of fexinidazole—a drug candidate in clinical development for human African trypanomiasis (sleeping sickness) [PDF]

, 2017
The parasitic disease human African trypanomiasis (HAT), also known as sleeping sickness, is a highly neglected fatal condition endemic in sub-Saharan Africa, which is poorly treated with medicines that are toxic, no longer effective or very difficult to
Bourdin Trunz, Bernadette, Torreele, Els, Tweats, David   +2 more
core