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Nitrones: Comprehensive Review on Synthesis and Applications [PDF]

Molecules
Nitrones are a significant class of compounds highly useful in organic synthesis; in particular, they are key intermediates for the synthesis of new biologically active nitrogen compounds.
Ricardo A. L. S. Santos, Artur M. S. Silva, Diana C. G. A. Pinto   +2 more
doaj   +2 more sources

Phosphorylated Nitrones—Synthesis and Applications [PDF]

Molecules
Phosphorylated nitrones belong to an important class of compounds with several applications, such as their therapeutic potency to reduce oxidative stress or as spin-trapping agents.
Iwona Rozpara, José Marco-Contelles, Dorota G. Piotrowska, Iwona E. Głowacka   +3 more
doaj   +2 more sources

Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones [PDF]

Antioxidants, 2022
Herein, we report the synthesis and antioxidant capacity of twelve novel 1,2,3-triazole-containing nitrones such as N-(2-(4-aryl-1H-1,2,3-triazol-1-yl)ethylidene)methanamine oxides 8a–f and N-(2-(4-aryl)-1H-1,2,3-triazol-1-yl)ethylidene)-2-methylpropan-2-
Dimitra Hadjipavlou-Litina, Iwona E. Głowacka, José Marco-Contelles, Dorota G. Piotrowska   +3 more
doaj   +2 more sources

Neuroprotective and Antioxidant Properties of CholesteroNitrone ChN2 and QuinolylNitrone QN23 in an Experimental Model of Cerebral Ischemia: Involvement of Necrotic and Apoptotic Cell Death [PDF]

Antioxidants, 2023
Ischemic stroke is the leading cause of disability and the second leading cause of death worldwide. However, current therapeutic strategies are scarce and of limited efficacy.
Beatriz Chamorro, Sara Izquierdo-Bermejo, María Dolores Martín-de-Saavedra, Francisco López-Muñoz, Mourad Chioua, José Marco-Contelles, María Jesús Oset-Gasque   +6 more
doaj   +2 more sources

Synthesis and Biological Activity Study of Co and Cr Complexes with α-(2-Salsayl)-N-phenyl Nitrone and Oxide Nanoparticles

Indonesian Journal of Chemistry, 2023
This paper describes the synthesis of two complexes from the ligand α-(2-Salsayl)-N-phenyl nitrone with CoCl2 and CrCl2. The ligand was characterized by several spectroscopic techniques (ultraviolet/visible (UV/Vis), nuclear magnetic resonance (1H-NMR ...
Dhamiaa Abdul-Shaheed Issa, Hayder Baqer Abdullah, Faeza Abdulkareem Al-Mashal   +2 more
doaj   +3 more sources

α-Phenyl-N-tert-Butylnitrone and Analogous α-Aryl-N-alkylnitrones as Neuroprotective Antioxidant Agents for Stroke [PDF]

Antioxidants
The recent advances in research on the use of the antioxidant and neuroprotective agent α-phenyl-N-tert-butylnitrone (PBN) for the therapy of stroke have been reviewed. The protective effect of PBN in the transient occlusion of the middle cerebral artery
José Marco-Contelles
doaj   +2 more sources

Enantioselective formal (3 + 3) cycloaddition of bicyclobutanes with nitrones enabled by asymmetric Lewis acid catalysis [PDF]

Nature Communications
The absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery.
Wen-Biao Wu, Bing Xu, Xue-Chun Yang, Feng Wu, Heng-Xian He, Xu Zhang, Jian-Jun Feng   +6 more
doaj   +2 more sources

In Vitro Modulation of Autophagy by New Antioxidant Nitrones as a Potential Therapeutic Approach for the Treatment of Ischemic Stroke [PDF]

Antioxidants
Stroke is a leading cause of death worldwide, yet current therapeutic strategies remain limited. Among the neuropathological events underlying this disease are multiple cell death signaling cascades, including autophagy.
Sara Izquierdo-Bermejo, Beatriz Chamorro, María Dolores Martín-de-Saavedra, Miguel Lobete, Francisco López-Muñoz, José Marco-Contelles, María Jesús Oset-Gasque   +6 more
doaj   +2 more sources

Correction to "B(C₆F₅)₃-Catalyzed Diastereoselective and Divergent Reactions of Vinyldiazo Esters with Nitrones: Synthesis of Highly Functionalized Diazo Compounds". [PDF]

Org Lett
Stefkova K, Guerzoni MG, van Ingen Y, Richards E, Melen RL.   +4 more
europepmc   +3 more sources

Iron-Catalyzed Alkylation-Reduction of <i>N</i>-Methyl Nitrones via LMCT Activation. [PDF]

Org Lett
Gonçalves RO, Vélez JAC, Debia NP, Oliveira PHR, Larroza A, Alves D, Paixão MW.   +6 more
europepmc   +2 more sources