Results 1 to 10 of about 13,292 (250)

Synthesis and Antioxidant Properties of Novel 1,2,3-Triazole-Containing Nitrones [PDF]

Antioxidants, 2022
Herein, we report the synthesis and antioxidant capacity of twelve novel 1,2,3-triazole-containing nitrones such as N-(2-(4-aryl-1H-1,2,3-triazol-1-yl)ethylidene)methanamine oxides 8a–f and N-(2-(4-aryl)-1H-1,2,3-triazol-1-yl)ethylidene)-2-methylpropan-2-
Dimitra Hadjipavlou-Litina, Iwona E. Głowacka, José Marco-Contelles, Dorota G. Piotrowska   +3 more
doaj   +3 more sources

Enantioselective formal (3 + 3) cycloaddition of bicyclobutanes with nitrones enabled by asymmetric Lewis acid catalysis [PDF]

Nature Communications
The absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery.
Wen-Biao Wu, Bing Xu, Xue-Chun Yang, Feng Wu, Heng-Xian He, Xu Zhang, Jian-Jun Feng   +6 more
doaj   +3 more sources

Phosphorylated Nitrones—Synthesis and Applications [PDF]

Molecules
Phosphorylated nitrones belong to an important class of compounds with several applications, such as their therapeutic potency to reduce oxidative stress or as spin-trapping agents.
Iwona Rozpara, José Marco-Contelles, Dorota G. Piotrowska, Iwona E. Głowacka   +3 more
doaj   +5 more sources

Insights into the Antioxidant Mechanism of Newly Synthesized Benzoxazinic Nitrones: In Vitro and In Silico Studies with DPPH Model Radical

Antioxidants, 2021
Synthetic nitrone spin-traps are being explored as therapeutic agents for the treatment of a wide range of oxidative stress-related pathologies, including but not limited to stroke, cancer, cardiovascular, and neurodegenerative diseases. In this context,
Stefania Marano, Cristina Minnelli, Lorenzo Ripani, Massimo Marcaccio, Emiliano Laudadio, Giovanna Mobbili, Adolfo Amici, Tatiana Armeni, Pierluigi Stipa   +8 more
doaj   +2 more sources

Amidinoquinoxaline-Based Nitrones as Lipophilic Antioxidants [PDF]

Antioxidants, 2021
The potential of nitrones (N-oxides) as therapeutic antioxidants is due to their ability to counteract oxidative stress, mainly attributed to their action as radical scavengers toward C- and O-centered radicals.
Nadia Gruber, Liliana Orelli, Cristina Minnelli, Luca Mangano, Emiliano Laudadio, Giovanna Mobbili, Pierluigi Stipa   +6 more
doaj   +4 more sources

Dialkylzinc‐Assisted Alkynylation of Nitrones. [PDF]

Organic Letters, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Sandra Pinet, Shashi U. Pandya, Pierre Y. Chavant, Alexander Ayling, Yannick Vallée   +4 more
openalex   +6 more sources

Reactions of a-Ketosulfenes with Nitrones

HETEROCYCLES, 1976
AbstractDie Sulfene (I), (II) und (III) ergeben mit den Nitronen (IV) unter Umlagerung siebengliedrige, cyclische Azasultone.
Otohiko Tsuge, Michihiko Noguchi
openalex   +3 more sources

PHOSPHONATED ISOXAZOLIDINYL NUCLEOSIDES, A NEW CLASS OF MODIFIED NUCLEOSIDES [PDF]

Euromediterranean Biomedical Journal, 2014
This review offers an overview of the synthesis of phosphonated isoxazolidinyl nucleosides, a new class of interesting and potentially antiviral/antitumor agents.
Salvatore Giofrè
doaj   +1 more source

Use of Radical Oxygen Species Scavenger Nitrones to Treat Oxidative Stress-Mediated Hearing Loss: State of the Art and Challenges

Frontiers in Cellular Neuroscience, 2021
Nitrones are potent antioxidant molecules able to reduce oxidative stress by trapping reactive oxygen and nitrogen species. The antioxidant potential of nitrones has been extensively tested in multiple models of human diseases. Sensorineural hearing loss
Isabel Varela-Nieto, Isabel Varela-Nieto, Isabel Varela-Nieto, Silvia Murillo-Cuesta, Silvia Murillo-Cuesta, Silvia Murillo-Cuesta, Lourdes Rodríguez-de la Rosa, Lourdes Rodríguez-de la Rosa, Lourdes Rodríguez-de la Rosa, María Jesús Oset-Gasque, María Jesús Oset-Gasque, José Marco-Contelles   +11 more
doaj   +1 more source

Nitrones as therapeutics [PDF]

Free Radical Biology and Medicine, 2008
Nitrones have the general chemical formula X-CH=NO-Y. They were first used to trap free radicals in chemical systems and then subsequently in biochemical systems. More recently several nitrones, including alpha-phenyl-tert-butylnitrone (PBN), have been shown to have potent biological activity in many experimental animal models.
Sabrina Doblas, Robert A. Floyd, Richard D. Kopke, Richard D. Kopke, Chul-Hee Choi, Rheal A. Towner, Steven B. Foster   +6 more
openaire   +3 more sources