Results 81 to 90 of about 7,313 (206)

Trimethylsilyl chloride promoted synthesis of a-branched amines by nucleophilic addition of organozinc halides to nitrones [PDF]

, 2012
A general procedure for the nucleophilic addition of organo-zinc halides with nitrones in the presence of trimethylsilyl chloride has been developed.
Chen, Y, Fu, Y, Hu, Y, Huang, D, Hugel, H, Liu, Y, Wang, M   +6 more
core  

Recent Advances in Bioconjugation of Aromatic Amino Acid Residues by a Reactivity‐Guided Approach

The Chemical Record, Volume 26, Issue 2, February 2026.
This review highlights recent advances in the bioconjugation of aromatic amino acids residues, focusing on strategies that leverage their inherent chemical reactivity to enable precise and versatile modifications of biomacromolecules, illustrating relevant applications.
Bruno M. da S. Santos, Lívia C. R. M. da Frota, Thais G. Silva, Fernanda G. Finelli   +3 more
wiley   +1 more source

Exo Selective Enantioselective Nitrone Cycloadditions [PDF]

Journal of the American Chemical Society, 2003
We have developed a novel method for accessing exo adducts with high enantioselectivity in nitrone cycloadditions to enoates. Pyrazolidinones proved to be effective achiral templates in the cycloadditions, providing exo adducts typically in >15:1 selectivity and 90-98% ee.
Mukund P, Sibi, Zhihua, Ma, Craig P, Jasperse   +2 more
openaire   +2 more sources

Solvent-Free 1,3-Dipolar Cycloadditions of Nitrones for a More Sustainable Synthesis of Glycomimetics

Reactions
1,3-Dipolar cycloadditions on nitrone dipoles are key reactions to access five-membered heterocycles, which are useful intermediates in the synthesis of biologically relevant glycomimetics.
Debora Pratesi, Alessio Morano, Andrea Goti, Francesca Cardona, Camilla Matassini   +4 more
doaj   +1 more source

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

Discovery of a Potent α ‑ Galactosidase Inhibitor by in Situ Analysis of a Library of Pyrrolizidine − (Thio)urea Hybrid Molecules Generated via Click Chemistry [PDF]

, 2018
The parallel synthesis of a 26-membered-library of aromatic/aliphatic-(thio)urea-linked pyrrolizidines followed by in situ biological evaluation toward α -galactosidases has been carried out.
Carmona Asenjo, Ana Teresa, Elías Rodríguez, María del Pilar, Ide, Daisuke, Kato, Atsushi, Miyawaki, Shota, Moreno Vargas, Antonio José, Pingitore, Valeria, Robina Ramírez, Inmaculada, Álvarez González, Eleuterio   +8 more
core   +1 more source

Skeletal Editing of Alkenes with Nitroarenes via Photoinduced Rearrangement of N─O═C Dipoles Forms Lactams and Amides

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Skeletal editing of alkenes via the cascade cleavage of C(sp2)═C(sp2) and C(sp3)─C(sp3) bonds, enabling the insertion of the nitrogen atom and thereby the synthesis of lactam and amide derivatives using nitroarenes as nitrogen atom insertion reagents under light irradiation.
Hongyun Qin, Zemin Wang, Cong Shi, Jiashu Chen, Chao Liu, Xiangqian Li, Ruihua Liu, Dayong Shi   +7 more
wiley   +1 more source

From Molecule to Meaning: Click and Bioorthogonal Chemical Reporters for Plant Systems, Biological Imaging, and Artistic Expression

ChemBioChem, Volume 27, Issue 1, January 2026.
At the intersection of chemical biology, plant imaging, and contemporary art, this review introduces the concept of chembioart. By tracing how chemical reporters illuminate plant biomolecules in vivo, their role not only in advancing scientific understanding but also in inspiring transdisciplinary collaborations and visual expression is highlighted ...
Marie Hinnebo, Clémence Simon, Adèle Tilouine, Corentin Spriet, Christophe Biot   +4 more
wiley   +1 more source

Addition of lithiated enol ethers to nitrones and subsequent Lewis acid induced cyclizations to enantiopure 3,6-dihydro-2H-pyrans – an approach to carbohydrate mimetics

Beilstein Journal of Organic Chemistry, 2010
A stereodivergent synthesis of enantiopure 3,6-dihydro-2H-pyrans is presented. The addition of lithiated enol ethers to carbohydrate-derived nitrones afforded syn- or anti-configured hydroxylamine derivatives 4a–d that were cyclized under Lewis acidic ...
Fabian Pfrengle, Hans-Ulrich Reissig
doaj   +1 more source

Kinugasa Reactions in Water: From Green Chemistry to Bioorthogonal Labelling

Molecules, 2015
The Kinugasa reaction has become an efficient method for the direct synthesis of β-lactams from substituted nitrones and copper(I) acetylides. In recent years, the reaction scope has been expanded to include the use of water as the solvent, and with ...
Mariya Chigrinova, Douglas A. MacKenzie, Allison R. Sherratt, Lawrence L. W. Cheung, John Paul Pezacki   +4 more
doaj   +1 more source