Results 1 to 10 of about 6,898 (201)

2,5-Di-tert-butyl-2,5-diethylpyrrolidine-1-oxyls: Where Is a Reasonable Limit of Sterical Loading for Higher Resistance to Reduction? [PDF]

Molecules
The pyrrolidine nitroxides with four bulky alkyl substituents adjacent to the N–O∙ group demonstrate very high resistance to reduction with biogenic antioxidants and enzymatic systems.
Irina F. Zhurko, Sergey A. Dobrynin, Yurii I. Glazachev, Yuri V. Gatilov, Igor A. Kirilyuk   +4 more
doaj   +2 more sources

Synthesis of Sterically Shielded Nitroxides Using the Reaction of Nitrones with Alkynylmagnesium Bromides

Molecules, 2022
Sterically shielded nitroxides, which demonstrate high resistance to bioreduction, are the spin labels of choice for structural studies inside living cells using pulsed EPR and functional MRI and EPRI in vivo.
Sergey A. Dobrynin, Mark M. Gulman, Denis A. Morozov, Irina F. Zhurko, Andrey I. Taratayko, Yulia S. Sotnikova, Yurii I. Glazachev, Yuri V. Gatilov, Igor A. Kirilyuk   +8 more
doaj   +1 more source

Cyclic Hydroxylamines as Monitors of Peroxynitrite and Superoxide-Revisited

Antioxidants, 2021
There is a considerable need for methods that allow quantitative determination in vitro and in vivo of transient oxidative species such as peroxynitrite (ONOOH/ONOO−) and superoxide (HO2•/O2•−).
Uri Samuni, Amram Samuni, Sara Goldstein
doaj   +1 more source

Amphiphilic branched polymer-nitroxides conjugate as a nanoscale agent for potential magnetic resonance imaging of multiple objects in vivo

Journal of Nanobiotechnology, 2021
Background In order to address the potential toxicity of metal-based magnetic resonance imaging (MRI) contrast agents (CAs), a concept of non-metallic MRI CAs has emerged. Currently, paramagnetic nitroxides (such as (2,2,5,5-tetramethylpyrrolidine-1-oxyl,
Xiaoming Wang, Shiwei Guo, Zhiqian Li, Qiang Luo, Yan Dai, Hu Zhang, Yun Ye, Qiyong Gong, Kui Luo   +8 more
doaj   +1 more source

A nitroxides-based macromolecular MRI contrast agent with an extraordinary longitudinal relaxivity for tumor imaging via clinical T1WI SE sequence

Journal of Nanobiotechnology, 2021
Background Macromoleculization of nitroxides has been an effective strategy to improve low relaxivities and poor in vivo stability, however, nitroxides-based metal-free magnetic resonance imaging (MRI) macromolecular contrast agents (mCAs) are still ...
Shiwei Guo, Xiaoming Wang, Zhiqian Li, Dayi Pan, Yan Dai, Yun Ye, Xiaohe Tian, Zhongwei Gu, Qiyong Gong, Hu Zhang, Kui Luo   +10 more
doaj   +1 more source

Strategies for synthesis of yardsticks and abaci for nanometre distance measurements by pulsed EPR [PDF]

, 2014
Silvia Valera is grateful for support by EPSRC and Bela E. Bode acknowledges support by EastCHEM.Pulsed electron paramagnetic resonance (EPR) techniques have been found to be an efficient tool for elucidation of structure in complex biological systems as
Bode, Bela Ernest, Valera, Silvia
core   +6 more sources

2-Butyl-2-tert-butyl-5,5-diethylpyrrolidine-1-oxyls: Synthesis and Properties

Molecules, 2020
Nitroxides are broadly used as molecular probes and labels in biophysics, structural biology, and biomedical research. Resistance of a nitroxide group bearing an unpaired electron to chemical reduction with low-molecular-weight antioxidants and enzymatic
Irina F. Zhurko, Sergey Dobrynin, Artem A. Gorodetskii, Yuri I. Glazachev, Tatyana V. Rybalova, Elena I. Chernyak, Nargiz Asanbaeva, Elena G. Bagryanskaya, Igor A. Kirilyuk   +8 more
doaj   +1 more source

3,4-Unsubstituted 2-tert-Butyl-pyrrolidine-1-oxyls with Hydrophilic Functional Groups in the Side Chains

Molecules, 2022
Pyrrolidine nitroxides with four bulky alkyl substituents adjacent to N–O group are known for their high resistance to bioreduction. The 3,4-unsubstituted 2-tert-butyl-2-ethylpyrrolidine-1-oxyls were prepared from the corresponding 2-tert-butyl-1 ...
Andrey I. Taratayko, Yurii I. Glazachev, Ilia V. Eltsov, Elena I. Chernyak, Igor A. Kirilyuk   +4 more
doaj   +1 more source

Syntheses and Reactions of Pyrroline, Piperidine Nitroxide Phosphonates

Molecules, 2020
Organophosphorus compounds occupy a significant position among the plethora of organic compounds, but a limited number of paramagnetic phosphorus compounds have been reported, including paramagnetic phosphonates.
Mostafa Isbera, Balázs Bognár, József Jekő, Cecilia Sár, Kálmán Hideg, Tamás Kálai   +5 more
doaj   +1 more source

A novel profluorescent dinitroxide for imaging polypropylene degradation [PDF]

, 2008
Free-radical processes underpin the thermo-oxidative degradation of polyolefins. Thus, to extend the lifetime of these polymers, stabilizers are generally added during processing to scavenge the free radicals formed as the polymer degrades.
Fairfull-Smith, Kathryn E., Blinco, James P., Keddie, Daniel J., George, Graeme A., Bottle, Steven E.   +4 more
core   +2 more sources