The Effect of Piperidine Nitroxides on the Properties of Metalloproteins in Human Red Blood Cells [PDF]
Molecules, 2023 Nitroxides are stable, low molecular-weight radicals containing a nitroxide group that has an unpaired electron. The presence of a nitroxide group determines their redox properties.
Stella Bujak-Pietrek +3 more
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Structural Features Governing the Metabolic Stability of Tetraethyl-Substituted Nitroxides in Rat Liver Microsomes [PDF]
Antioxidants, 2023 Nitroxides are potent tools for studying biological systems by electron paramagnetic resonance (EPR). Whatever the application, a certain stability is necessary for successful detection.
Aleksandra Rančić +3 more
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Nitroxides: Chemistry, Antioxidant Properties, and Biomedical Applications [PDF]
MoleculesNitroxides are stable organic free radicals with a wide range of applications. They have found applications in chemistry, biochemistry, biophysics, molecular biology, and biomedicine as EPR/NMR imaging techniques. As spin labels and probes, they are used
Krzysztof Gwozdzinski +2 more
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Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications [PDF]
Anais da Academia Brasileira de Ciências, 2008 The substantial therapeutic potential of tempol (4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy) and related cyclic nitroxides as antioxidants has stimulated innumerous studies of their reactions with reactive oxygen species.
Ohara Augusto +3 more
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Modulation of the Human Erythrocyte Antioxidant System by the 5- and 6-Membered Heterocycle-Based Nitroxides [PDF]
MoleculesNitroxides are stable radicals consisting of a nitroxyl group, >N-O•, which carries an unpaired electron. This group is responsible for the paramagnetic and antioxidant properties of these compounds.
Krzysztof Gwozdzinski +3 more
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Nitroxide-Based Contrast Agents for MRI Cancer Diagnostics: Progress, Limitations, and Perspectives [PDF]
MoleculesMagnetic resonance imaging (MRI) is one of the most powerful non-invasive methods for cancer diagnostics. To enhance image contrast and, therefore, diagnostic accuracy, contrast agents (CAs) are widely used in clinics.
Dmitry Mitin, Alexey Chubarov
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Conformational tuning improves the stability of spirocyclic nitroxides with long paramagnetic relaxation times [PDF]
Communications Chemistry, 2023 Nitroxides are widely used as probes and polarization transfer agents in spectroscopy and imaging. These applications require high stability towards reducing biological environments, as well as beneficial relaxation properties.
Mateusz P. Sowiński +6 more
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Synthesis of tricyclic fused pyrrolidine nitroxides from 2-alkynylpyrrolidine-1-oxyls [PDF]
Beilstein Journal of Organic ChemistryRotational correlation time is a key parameter for organic radical contrast agents (ORCA) for magnetic resonance imaging (MRI). Design of polycyclic systems with incorporated nitroxide moieties in which rotation of the radical separately from the ...
Mark M. Gulman +6 more
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Redox-active nitroxides enhance cisplatin efficacy against cervical cancer [PDF]
Redox BiologyCisplatin remains the primary treatment for most cervical cancer cases, though its clinical efficacy is hindered by dose-dependent toxicity and incurring chemoresistance.
Carl P. Soltau +9 more
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Catalytic System for Cross-Coupling of Heteroaryl Iodides with a Nitronyl Nitroxide Gold Derivative at Room Temperature [PDF]
Molecules, 2023 A simple and highly effective methodology for the cross-coupling of heteroaryl iodides with NN–AuPPh3 at room temperature is reported. The protocol is based on a novel catalytic system consisting of Pd2(dba)3·CHCl3 and the phosphine ligand MeCgPPh having
Igor Zayakin +5 more
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