Results 101 to 110 of about 316,773 (316)

Hhex Directly Represses BIM-Dependent Apoptosis to Promote NK Cell Development and Maintenance [PDF]

, 2020
Hhex encodes a homeobox transcriptional regulator important for embryonic development and hematopoiesis. Hhex is highly expressed in NK cells, and its germline deletion results in significant defects in lymphoid development, including NK cells.
Davis, MJ, Hediyeh-Zadeh, S, Rautela, J, Nutt, SL, Scheer, S, Jackson, JT, Delconte, RB, McCormack, MP, Degli-Esposti, MA, Andoniou, CE, Huntington, ND, Goh, W, Schuster, IS   +12 more
core   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Clonal origin of Epstein-Barr virus-infected T/NK-cell subpopulations in chronic active Epstein-Barr virus infection [PDF]

, 2010
Clonal expansion of Epstein-Barr virus (EBV) infected B-cells occasionally occurs in immunocompromized subjects. EBV-infected T/natural killer (NK)-cells proliferate in patients with chronic active EBV infection (CAEBV) that is a rare mononucleosis ...
Tamami Tanaka, Ken-Ichi Imadome, Toshihiro Miyamoto, Koichi Akashi, Hidetoshi Takada, Koichi Ohshima, Yasunobu Abe, Toshiro Hara, Shouichi Ohga, Masataka Ishimura, Goichi Toshimoto   +10 more
core   +1 more source

Intra-lineage plasticity and functional reprogramming maintain natural killer cell repertoire diversity [PDF]

, 2019
Natural killer (NK) cell repertoires are made up of phenotypically distinct subsets with different functional properties. The molecular programs involved in maintaining NK cell repertoire diversity under homeostatic conditions remain elusive.
Malmberg, K-J, Ask, Eivind Heggernes, Goodridge, Jodie, Lorenz, S, Lorenz, Susanne, Goodridge, JP, Clancy, T, Malmberg, Karl-Johan, Pfefferle, A,, Sohlberg, Ebba, Sohlberg, E,, Jacobs, Benedikt Marcel, Netskar, Herman, Netskar, H, Ask, EH, Pfefferle, Aline, Clancy, Trevor, Jacobs, B   +17 more
core   +1 more source

Mechanism of LEPR-mediated cholesterol metabolism involved in NK cell function suppression under simulated microgravity

npj Microgravity
Natural killer (NK) cells play an important role in antitumor and viral resistance. However, the mechanism of impaired NK cell function in microgravity remains unclear.
Hongfang Lv, Huan Yang, Xiaojia Guo, Jing Li, Yuanyuan Xie, Chunmei Jiang, Junling Shi, Qingsheng Huang, Dongyan Shao   +8 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Antiviral treatment alters the frequency of activating and inhibitory receptor-expressing natural killer cells in chronic Hepatitis B virus infected patients [PDF]

, 2012
Natural killer (NK) cells play a critical role in innate antiviral immunity, but little is known about the impact of antiviral therapy on the frequency of NK cell subsets.
Xiumei Chi, Lv, J., Yu Pan, Zhigang Tian, Niu, J., Juan Lv, Weihua Xiao, Yan, H., Xu, D., Zhengkun Tu, Hu, X., Chi, X., Junqi Niu, Qinglong Jin, Xiao, W., Sun, H., Hou, J., Jinlin Hou, Hongqing Yan, Haibo Sun, Tian, Z., Tu, Z., Xiaoli Hu, Jin, Q., Pan, Y., Damo Xu   +25 more
core   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Characterisation and ontogeny of natural killer cells in Xenopus laevis [PDF]

, 2002
The initial aim of the work described in this Thesis was to investigate the lymphoid organ distribution, phenotype and function of the lymphocyte population identified by candidate anti-Xenopus natural killer (NK) cell monoclonal antibodies (mAb's ...
Stewart, Rebecca
core  

Killing of Kaposi's sarcoma-associated herpesvirus-infected fibroblasts during latent infection by activated natural killer cells. [PDF]

, 2011
Kaposi's sarcoma-associated herpesvirus (KSHV) establishes life-long infection by evading clearance by the host immune system. In de novo infection and lytic replication, KSHV escapes cytotoxic T cells and NK cells through downregulation of MHC class-I ...
Nick C. Matthews, Gotch, FM, Frances M. Gotch, Robey, Rebecca C, Bower, Mark, Rebecca C. Robey, Mark Bower, Matthews, Nick C, Goodier, Martin R, Bower, M, Goodier, MR, Robey, RC, Gotch, Frances M, Martin R. Goodier, Matthews, NC   +14 more
core   +1 more source