Results 81 to 90 of about 316,773 (316)
NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation
Frontiers in Immunology, 2019 Natural killer (NK) cells can produce IFNγ or IL-10 to regulate inflammation and immune responses but the factors driving NK cell IL-10 secretion are poorly-defined.
Sarah E. Clark +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Activation of human natural killer cells by Plasmodium falciparum [PDF]
, 2003 The purpose of work described in this thesis was to (i) determine the contribution of innate immune responses to the early pro-inflammatory cytokine response to Plasmodium falciparum, (ii) describe the kinetics and ...
Artavanis-Tsakonas, Katerina
core +1 more source
BiomedicinesBackground/Objectives: Natural killer (NK) cells play a crucial role in tumor surveillance by exerting cytotoxic activity and modulating immune responses. However, tumors employ diverse evasion strategies that limit NK cell effectiveness.
Paula Morcillo-Martín-Romo +6 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Tumor recognition by natural killer cells in acute myeloid leukemia and after hematopoietic stem cell transplantation [PDF]
, 2005 Natural killer (NK) cell-mediated cytolytic activity against tumors requires the engagement of activating NK cell receptors by the tumor-associated ligands.
Nowbakht, Pegah
core +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Natural killer cell evolution: cellular and molecular studies on Xenopus [PDF]
, 1996 The presence of natural killer cells at lower evolutionary levels was investigated in the amphibian Xenopus laevis. Chromium release microcytotoxicity assays revealed that fresh splenocytes from early-thymectomised Xenopus displayed significant ...
Horsham, Karen
core
NK cells and poxvirus infection [PDF]
Frontiers in Immunology, 2013 In recent years, our understanding of the role of natural killer (NK) cells in the response to viral infection has grown rapidly. Not only do we realize viruses have many immune-evasion strategies to escape NK cell responses, but that stimulation of NK cell subsets during an antiviral response occurs through receptors seemingly geared directly at viral
openaire +3 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source