Results 71 to 80 of about 316,773 (316)

Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow [PDF]

, 2023
Natural killer (NK) cells are innate immune cells critical for protective immune responses against infection and cancer. Although NK cells differentiate in the bone marrow (BM) in an interleukin-15 (IL-15)-dependent manner, the cellular source of IL-15 ...
Tani-Ichi, Shizue (Kyoto University), Miyazaki, Kazuko (Kyoto University), Sexl, Veronika (University of Veterinary Medicine Vienna), Nakamura, Naotoshi (Nagoya University), Kitano, Satsuki (Kyoto University), Yamada, Kohei (Kyoto University), Miyachi, Hitoshi (Kyoto University), Ohteki, Toshiaki (Tokyo Medical and Dental University), Ikuta, Koichi (Kyoto University), Hara, Takahiro (Kyoto University), Nagasawa, Takashi (Osaka University), Cui, Guangwei (Kyoto University), Miyazaki, Masaki (Kyoto University), Abe, Shinya (Kyoto University), Vandenbon, Alexis (Kyoto University), Asahi, Takuma (Kyoto University), Kikuta, Junichi (Osaka University), Shimba, Akihiro (Kyoto University), Yamada, Ryo (Kyoto University), Ishii, Masaru (Osaka University)   +19 more
core   +1 more source

Impact of the Variable Killer Ig-Like Receptor–Human Leukocyte Antigen Interactions on Natural Killer Cell Cytotoxicity Toward Foreign CD4 T Cells

Frontiers in Immunology, 2018
BackgroundNatural killer (NK) cells are known to mount a response against foreign target cells, where the absence of the dominant inhibitory killer Ig-like receptor (KIR)–human leukocyte antigen (HLA) interaction immensely lowers the threshold for NK ...
Jef Hens, Jef Hens, Odin Goovaerts, Ann Ceulemans, Wim Jennes, Luc Kestens, Luc Kestens   +6 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Clonal acquisition of the Ly49A NK cell receptor is dependent on the trans-acting factor TCF-1 [PDF]

, 1999
Families of clonally expressed major histocompatibility complex (MHC) class I–specific receptors provide specificity to and regulate the function of natural killer (NK) cells.
van de Wetering, Marc, Clevers, H., Clevers, Hans, Kunz, B., Lowin-Kropf, Bente, Béatrice Kunz, Hans Clevers, Held, W., Marc van de Wetering, Kunz, Béatrice, Werner Held, van de Wetering, M., Clevers, J.C., Wetering, M. van de, Lowin-Kropf, B., Held, Werner, Bente Lowin-Kropf   +16 more
core   +1 more source

Feeder cell training shapes the phenotype and function of in vitro expanded natural killer cells

MedComm
Natural killer (NK) cells are candidates for adoptive cell therapy, and the protocols for their activation and expansion profoundly influence their function and fate.
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Loïs Coënon, Caroline Multrier, Loïc Vaillant, Julien Peyroux, Tianxiang Zhang, Martin Villalba   +8 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Human Cytomegalovirus glycoprotein UL16 causes intracellular sequestration of NKG2D ligands, protecting against NK cell cytotoxicity. [PDF]

, 2003
The activating receptor, NKG2D, is expressed on a variety of immune effector cells and recognizes divergent families of major histocompatibility complex (MHC) class I-related ligands, including the MIC and ULBP proteins.
Sutherland, CL, Johnson, DC, N. Jan Chalupny, Chalupny, NJ, Claire Dunn, Sivakumar, PV, P.V. Sivakumar, Dunn, C, Dosch, S, David Cosman, David C. Johnson, Cosman, D, Stephanie Dosch, Claire L. Sutherland   +13 more
core   +1 more source

Molecular Regulation of NK Cell Maturation

Frontiers in Immunology, 2020
Natural killer (NK) cells are innate lymphocytes specialized in immune surveillance against tumors and infections. To reach their optimal functional status, NK cells must undergo a process of maturation from immature to mature NK cells.
Jiacheng Bi, Xuefu Wang
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Recognition of Human Histocompatibility Leukocyte Antigen (HLA)-E Complexed with HLA Class I Signal Sequence–derived Peptides by D94/NKG2 Confers Protection from Natural Killer Cell–mediated Lysis [PDF]

, 1998
Human histocompatibility leukocyte antigen (HLA)-E is a nonclassical HLA class I molecule, the gene for which is transcribed in most tissues. It has recently been reported that this molecule binds peptides derived from the signal sequence of HLA class I ...
John E. Coligan, Matthias Ulbrecht, Ulbrecht, Matthias, Coligan, John E., Andrew G. Brooks, Brooks, AG, Borrego, F, Coligan, JE, Elisabeth H. Weiss, Brooks, Andrew G., Francisco Borrego, Borrego, Francisco, Weiss, Elisabeth H., Ulbrecht, M, Weiss, EH   +14 more
core   +1 more source