Results 131 to 140 of about 12,636,240 (404)

RAC2 inhibition enhances tumor sensitivity to NK cell-mediated cytotoxicity

Journal for ImmunoTherapy of Cancer
Background Natural killer (NK) cells are recognized for their ability to kill tumor cells for tumor control, but tumor cells often develop resistance to evade NK cell-mediated cytotoxicity.
Lin Li, Hui Guo, Jie Hu, Lei Cui, Zining Wang, Feifei Xu, Xiaojuan Wang, Huanling Zhang, Chunyuan Xie, Yongxiang Liu, Xiaojun Xia, Zixuan Guo, Heping Li, Tiantian Wang, Ruhui Yao, Huan Jin, Yanxun Lin   +16 more
doaj   +1 more source

Continuously expanding CAR NK-92 cells display selective cytotoxicity against B-cell leukemia and lymphoma [PDF]

, 2017
Background aims Natural killer (NK) cells can rapidly respond to transformed and stressed cells and represent an important effector cell type for adoptive immunotherapy.
Bader, Peter, Badura, Susanne, Friede, Miriam E., Klingemann, Hans, Oelsner, Sarah, Ottmann, Oliver, Tonn, Torsten, Ullrich, Evelyn, Wagner, Juliane, Wels, Winfried S., Zhang, Congcong   +10 more
core   +2 more sources

Shaping Ti3C2 MXene Nanospheres for Precision Near‐Infrared Photothermal Therapy

Advanced Functional Materials, EarlyView.
In this study, we report producing spherical MXenes via fs laser fragmentation of Ti3C2 flakes in liquid medium. The nanoparticles demonstrated pronounced light absorption and high photothermal conversion efficiencies of 68% and 63% under heating with NIR‐I and NIR‐II lasers, respectively.
Julia S. Babkova, Ivan V. Zelepukin, Konstantin G. Shevchenko, Gleb V. Tikhonowski, Lyubov V. Gorelik, Anton A. Popov, Anna S. Sogomonyan, Alina Yu. Kapitannikova, Ivan S. Kazantsev, Dmitry V. Dyubo, Daria A. Panova, Daniil I. Tselikov, Anton A. Minnekhanov, Aziz B. Mirkasymov, Georgy A. Ermolaev, Alexander V. Syuy, Gleb I. Tselikov, Aleksey V. Arsenin, Andrei V. Kabashin, Kostya S. Novoselov, Sergey M. Deyev, Valentyn S. Volkov   +21 more
wiley   +1 more source

A novel NKp80-based strategy for universal identification of normal, reactive and tumor/clonal natural killer-cells in blood

Frontiers in Immunology
PurposeNatural killer (NK) cells are traditionally identified by flow cytometry using a combination of markers (CD16/CD56/CD3), because a specific NK-cell marker is still missing.
F. Javier Morán-Plata, F. Javier Morán-Plata, Noemí Muñoz-García, Noemí Muñoz-García, María González-González, María González-González, Julio Pozo, Julio Pozo, Sonia Carretero-Domínguez, Sonia Carretero-Domínguez, Sonia Carretero-Domínguez, Sheila Mateos, Sheila Mateos, Susana Barrena, Susana Barrena, Moncef Belhassen-García, Moncef Belhassen-García, Catarina Lau, Maria Dos Anjos Teixeira, Ana Helena Santos, Ana Yeguas, Ana Balanzategui, Ana Balanzategui, Alejandro Martín García-Sancho, Alejandro Martín García-Sancho, Alejandro Martín García-Sancho, Alejandro Martín García-Sancho, Alberto Orfao, Alberto Orfao, Alberto Orfao, Alberto Orfao, Julia Almeida, Julia Almeida, Julia Almeida, Julia Almeida   +34 more
doaj   +1 more source

PECULIARITIES OF NK CELLS DIFFERENTIATION: CD56dim AND CD56bright NK CELLS AT PREGNANCY AND IN NON-PREGNANT STATE

Медицинская иммунология, 2017
Natural killer (NK) cells represent a lymphocyte subpopulation which is capable of contact cytolysis of virus-infected cells and tumor cells, being a source of cytokines which stimulate other immune cells and promote immune response.
V. A. Mikhailova, K. L. Belyakova, S. A. Selkov, D. I. Sokolov   +3 more
doaj   +1 more source

Decision letter for "Cereblon regulates NK cell cytotoxicity and migration via Rac1 activation"

, 2021

openalex   +1 more source

Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells

Journal of Cell Biology, 2018
Natural Killer (NK) cells can engage multiple virally infected or tumor cells sequentially and deliver perforin for cytolytic killing of these targets.
Katja Srpan, A. Ambrose, Alexandros Karampatzakis, Mezida B. Saeed, Adam N. Cartwright, K. Guldevall, Gabriela Dos Santos Cruz De Matos, B. Önfelt, D. Davis   +8 more
semanticscholar   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

Advanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam, Seon Yeong Chae, Young Woo Kwon, Hye Jin Heo, Hye Rin Lee, Ji Hyeok Lee, Dong‐Wook Han, Yun Hak Kim, Suck Won Hong   +8 more
wiley   +1 more source

Natural killer cells as an initial defense against pathogens. [PDF]

, 2006
Natural killer (NK) cells serve as a crucial first line of defense against tumors and a diverse range of pathogens. Recognition of infection by NK cells is accomplished by the activation of receptors on the NK cell surface, which initiate NK cell ...
Lanier, Lewis L, Lodoen, Melissa B
core  

Biallelic mutations in IRF8 impair human NK cell maturation and function [PDF]

, 2017
Human NK cell deficiencies are rare yet result in severe and often fatal disease, particularly as a result of viral susceptibility. NK cells develop from hematopoietic stem cells, and few monogenic errors that specifically interrupt NK cell development ...
Angelo, LS, Bigley, V, Caligiuri, MA, Cant, AJ, Cao, TN, Care, MA, Chinn, IK, Coban Akdemir, Z, Collin, M, Doody, GM, Freud, AG, Gibbs, RA, Gunesch, JT, Hernandez-Sanabria, M, Hogg, GD, Holland, SM, Jhangiani, SN, Keller, MD, LaRosa, DF, Le, DT, Lupski, JR, Mace, EM, Maisuria, S, Muzny, DM, Orange, JS, Ozato, K, Paust, S, Savic, S, Smith, JB, Stray-Pederson, A, Szymanski, EP, Togi, S, Watkin, LB   +32 more
core   +1 more source