Results 161 to 170 of about 291,920 (218)

Beyond KIR and NKG2A blockade: reprogramming NK-cell immunity in solid tumors. [PDF]

Front Cell Dev Biol
Pastorino C, Falco M, Giordano C, Zarefeizabadi N, Rutigliani M, Carbone A, Clavarezza M, Ortolani F, Nanni L, Della Chiesa M, Sivori S, Carlomagno S.   +11 more
europepmc   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

A tumor-on-a-chip model reveals and targets reciprocal macrophage-NK cell crosstalk to advance immunotherapy screening. [PDF]

Microsyst Nanoeng
Han X, Chen Q, Li K, Wu J, Wang A, Wang Y, Zhao H, Liu W.   +7 more
europepmc   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Rbp-Jκ controls NK cell late maturation and migration via chromatin landscape remodeling. [PDF]

Proc Natl Acad Sci U S A
Peng H, Yang Y, Liu Y, Wu S, Hu D, Deng X, Huang L, Li Y, Xiong P, Yang Q, Li S, Gong B, Zhang Y, Song L, Wang F, Yu J, Xiao Z, Deng Y, Zhong Z, Deng Y.   +19 more
europepmc   +1 more source

Water‐Soluble Luminescent Trityl Radical for Fluorescence/Magnetic Resonance Dual‐Modal Imaging Probe

Advanced Science, EarlyView.
Stable water‐soluble luminescent tris(2,4,6‐trichlorophenyl)methyl (TTM) radicals, TTM‐trisTP3B and TTM‐trisTP9B, were designed and successfully synthesized. They exhibited deep‐red emissions and high photostability in water. TTM‐trisTP3B exhibited dual functionality as a fluorescence imaging (FI) probe and a magnetic resonance imaging (MRI) contrast ...
Kosuke Anraku, Satoshi Okada, Akira Sumiyoshi, Kenshiro Matsuda, Kazuhiro Nakamura, Takuya Hosokai, Ken Albrecht   +6 more
wiley   +1 more source

PGE2-mediated NK cell reprogramming drives acquired immunotherapy resistance in lung adenocarcinoma. [PDF]

J Immunother Cancer
Wang Y, Peng C, Feng S, Wen S, Xu C, Du X, Jiang W, Zou R, Shi Y, Ma Y, Xu Z, Jiang M, Shen B.   +12 more
europepmc   +1 more source

TIM3 Blockade with Hypomethylating Therapy Restores NK Cell and Cytotoxic CD4+ T-cell Activity in Patients with AML or MDS. [PDF]

Cancer Immunol Res
Huuhtanen J, Forstén S, Ford B, Smolander J, Brück O, Lundgren S, Kreutzman A, Dufva O, Kankainen M, Ilander M, Lähteenmäki H, Kasanen T, Klievink J, Leitner J, Steinberger P, Kontro M, Pelletier MR, Lähdesmäki H, Sabatos-Peyton C, Rinne ML, Porkka K, Peltonen K, Mustjoki S.   +22 more
europepmc   +1 more source

A Tumor‐Boundary Niche Enriched for PD‐1+CD8+T Cells and BTLA+B Cells Drives Resistance to Immunotherapy in NSCLC

Advanced Science, EarlyView.
A spatial niche composed of BTLA+B cells and CD8+T cells is enriched at the tumor boundary in non‐small cell lung cancer. Within this specialized niche, BTLA+B cells act as a dominant source of IL‐6, upregulating PD‐1 on CD8+T cells via STAT3 signaling.
Jiajuan Wu, Shiying Guo, Leilei Lv, Guiqin Fan, Yu Shen, Qiuxia Qu, Cheng Chen   +6 more
wiley   +1 more source