Results 71 to 80 of about 628,729 (310)

NK Cell IL-10 Production Requires IL-15 and IL-10 Driven STAT3 Activation

Frontiers in Immunology, 2019
Natural killer (NK) cells can produce IFNγ or IL-10 to regulate inflammation and immune responses but the factors driving NK cell IL-10 secretion are poorly-defined.
Sarah E. Clark, Kristina S. Burrack, Stephen C. Jameson, Sara E. Hamilton, Laurel L. Lenz   +4 more
doaj   +1 more source

Delineation and Modulation of the Natural Killer Cell Transcriptome in Rhesus Macaques During ZIKV and SIV Infections

Frontiers in Cellular and Infection Microbiology, 2020
Natural killer (NK) cells are crucial regulators of antiviral and anti-tumor immune responses. Although in humans some NK cell transcriptional programs are relatively well-established, NK cell transcriptional networks in non-human primates (NHP) remain ...
Malika Aid, Daniel R. Ram, Steven E. Bosinger, Dan H. Barouch, Dan H. Barouch, R. Keith Reeves, R. Keith Reeves   +6 more
doaj   +1 more source

Genetically modified natural killer cells specifically recognizing the tumor-associated antigens ErbB2/HER2 and EpCAM [PDF]

, 2007
The continuously growing natural killer (NK) cell line NK-92 is highly cytotoxic against malignant cells of various origin without affecting normal human cells.
Klingemann, Hans-Georg, Müller, Tina, Tonn, Torsten, Uherek, Barbara, Uherek, Christoph, Wels, Winfried S.   +5 more
core  

Altered distribution of mucosal NK cells during HIV infection. [PDF]

, 2012
The human gut mucosa is a major site of human immunodeficiency virus (HIV) infection and infection-associated pathogenesis. Increasing evidence shows that natural killer (NK) cells have an important role in control of HIV infection, but the mechanism(s ...
Alter, G, Berger, CT, Carrington, M, Deeks, SG, Diefenbach, T, Dugast, A-S, Estes, JD, Ghebremichael, M, Hunt, PW, Kwon, D, Liu, Q, Martin, JN, Sciaranghella, G, Sips, M   +13 more
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Feeder cell training shapes the phenotype and function of in vitro expanded natural killer cells

MedComm
Natural killer (NK) cells are candidates for adoptive cell therapy, and the protocols for their activation and expansion profoundly influence their function and fate.
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Loïs Coënon, Caroline Multrier, Loïc Vaillant, Julien Peyroux, Tianxiang Zhang, Martin Villalba   +8 more
doaj   +1 more source

Calcisponges have a ParaHox gene and dynamic expression of dispersed NK homeobox genes [PDF]

, 2014
This study was funded by the Sars Centre core budget to M. Adamska. Sequencing was performed at the Norwegian High Throughput Sequencing Centre funded by the Norwegian Research Council. O.M.R. and D.E.K.F.
A Saudemont, B Fahey, B Li, C Larroux, C Larroux, D Chourrout, D Darriba, DEK Ferrier, GN Luke, H-C Seo, J Garcia-Fernàndez, JF Ryan, JHL Hui, JHL Hui, KJ Peterson, M Boetzer, M Srivastava, MG Grabherr, N Takatori, O Mendivil Ramos, R Luo, S Amano, S Anders, S Fortunato, S Leininger, SA Fortunato, TM Keane, Y-F Zhong   +27 more
core   +2 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Impact of killer-immunoglobulin-like receptor and human leukocyte antigen genotypes on the efficacy of immunotherapy in acute myeloid leukemia [PDF]

, 2017
Interactions between killer-immunoglobulin-like receptors (KIRs) and their HLA class I ligands are instrumental in natural killer (NK) cell regulation and protect normal tissue from NK cell attack.
Aurelius, J., Bernson, E., Brune, M., Foà, R., Hallner, A., Hellstrand, K., Kiffin, R., Martner, A., Rydström, A., Sander, F. E., Thorén, F. B., Werlenius, O., Wilsson, O.   +12 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source