Results 71 to 80 of about 620,136 (263)

Inflammatory monocytes require type I interferon receptor signaling to activate NK cells via IL-18 during a mucosal viral infection [PDF]

, 2017
The requirement of type I interferon (IFN) for natural killer (NK) cell activation in response to viral infection is known, but the underlying mechanism remains unclear. Here, we demonstrate that type I IFN signaling in inflammatory monocytes, but not in
Ashkar, Ali A, Barra, Nicole G, Chen, Branson, Chew, Marianne V, Jordana, Manel, Lee, Amanda J, Mack, Matthias, Mossman, Karen L, Nham, Tina, Rooijen, Nico van, Schreiber, Robert D, Shenouda, Mira M   +11 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Anti-CD20 Therapy Acts via FcγRIIIA to Diminish Responsiveness of Human Natural Killer Cells [PDF]

, 2015
Natural killer (NK) immune cells mediate antibody-dependent cellular cytotoxicity (ADCC) by aggregating FcγRIIIA/CD16, contributing significantly to the therapeutic effect of CD20 monoclonal antibodies (mAb).
Capuano, Cristina, Cimino, Giuseppe, Galandrini, Ricciarda, Molfetta, Rosa, Paolini, Rossella, Pighi, Chiara, Rago, Angela, Romanelli, Maddalena, Santoni, Angela   +8 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

The Role of NK Cells in Cancer Immunotherapy: Mechanisms, Evasion Strategies, and Therapeutic Advances

Biomedicines
Background/Objectives: Natural killer (NK) cells play a crucial role in tumor surveillance by exerting cytotoxic activity and modulating immune responses. However, tumors employ diverse evasion strategies that limit NK cell effectiveness.
Paula Morcillo-Martín-Romo, Javier Valverde-Pozo, María Ortiz-Bueno, Maurizio Arnone, Laura Espinar-Barranco, Celia Espinar-Barranco, María Eugenia García-Rubiño   +6 more
doaj   +1 more source

A natural killer cell receptor specific for a major histocompatibility complex class I molecule. [PDF]

, 1994
Target cell expression of major histocompatibility complex (MHC) class I molecules correlates with resistance to lysis by natural killer (NK) cells.
Daniels, BF, Karlhofer, FM, Seaman, WE, Yokoyama, WM   +3 more
core  

Ubiquitin-dependent endocytosis of NKG2D-DAP10 receptor complexes activates signaling and functions in human NK cells [PDF]

, 2015
Cytotoxic lymphocytes share the presence of the activating receptor NK receptor group 2, member D (NKG2D) and the signaling-competent adaptor DNAX-activating protein 10 (DAP10), which together play an important role in antitumor immune surveillance ...
CAPUANO, CRISTINA, CIPPITELLI, Marco, FIONDA, Cinzia, GALANDRINI, Ricciarda, MOLFETTA, Rosa, PAOLINI, Rossella, PERUZZI, Giovanna, QUATRINI, LINDA, SANTONI, Angela, ZITTI, BEATRICE   +9 more
core   +1 more source

Tissue Determinants of Human NK Cell Development, Function, and Residence. [PDF]

, 2020
Immune responses in diverse tissue sites are critical for protective immunity and homeostasis. Here, we investigate how tissue localization regulates the development and function of human natural killer (NK) cells, innate lymphocytes important for anti ...
Arakawa-Hoyt, Janice, Carpenter, Dustin J, Dogra, Pranay, Farber, Donna L, Fong, Lawrence, Kubota, Masaru, Lanier, Lewis L, Li Poon, Maya Meimei, Li, Jacky, Ma, Wenji, Matsumoto, Rei, Rancan, Chiara, Senda, Takashi, Shen, Yufeng, Szabo, Peter A, Thapa, Puspa, Toth, Marta   +16 more
core   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice [PDF]

, 2015
Mice exposed to standard (SE) or enriched environment (EE) were transplanted with murine or human glioma cells and differences in tumour development were evaluated.
BENIGNI, GIORGIA, BERNARDINI, Giovanni, Brau, Frederic, CHECE, Giuseppina, D'ALESSANDRO, GIUSEPPINA, ESPOSITO, Vincenzo, GAROFALO, STEFANO, LAURO, CLOTILDE, LIMATOLA, Cristina, MAGGI, Laura, MAINIERO, Fabrizio, PORZIA, Alessandra, ROSA, ALESSANDRO, SANTONI, Angela   +13 more
core   +1 more source