Results 41 to 50 of about 262,765 (147)
Frontiers in Immunology, 2019 NK cells in the human lung respond to influenza A virus- (IAV-) infected target cells. However, the detailed functional capacity of human lung and peripheral blood NK cells remains to be determined in IAV and other respiratory viral infections.
Marlena Scharenberg +17 more
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Genome engineering of induced pluripotent stem cells to manufacture natural killer cell therapies
Stem Cell Research & Therapy, 2020 Natural killer (NK) cells play a crucial role in host immunity by detecting cells that downregulate MHC class I presentation and upregulate stress ligands, as commonly seen in cancers.
Keerthana Shankar +2 more
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Advances in Induced Pluripotent Stem Cell-Derived Natural Killer Cell Therapy
CellsNatural killer (NK) cells are cytotoxic lymphocytes of the innate immune system capable of killing virus-infected cells and/or cancer cells. The commonly used NK cells for therapeutic applications include primary NK cells and immortalized NK cell lines ...
Wenhua Qiao +3 more
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Lung tumor microenvironment induces specific gene expression signature in intratumoral NK cells
Frontiers in Immunology, 2013 Natural Killer (NK) cells are able to recognize and kill tumor cells, however whether they contribute to tumor immunosurveillance is still debated. Our previous studies demonstrated the presence of NK cells in human lung tumors.
Mélanie eGillard-Bocquet +22 more
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Evidence-Based Complementary and Alternative Medicine, 2004 It is believed that tumor development, outgrowth and metastasis are under the surveillance of the immune system. Although both innate and acquired immune systems play roles, innate immunity is the spearhead against tumors. Recent studies have revealed the critical role of natural killer (NK) cells in immune surveillance and that NK cell activity is ...
Takeda, Kazuyoshi, Okumura, Ko
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PLoS ONE, 2014 During chronic hepatitis C virus (HCV) infection, the role of intra-hepatic (IH) natural killer (NK) cells is still controversial. To clarify their functions, we investigated anti-viral and cytotoxic activity of NK cells in human fresh liver biopsies. We
Emilie Fugier +10 more
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Circulating CXCR5+ natural killer cells are expanded in patients with myasthenia gravis
Clinical & Translational Immunology, 2023 Objectives Myasthenia gravis (MG) is a classic autoantibody‐mediated disease in which pathogenic antibodies target postsynaptic membrane components, causing fluctuating skeletal muscle weakness and fatigue.
Meng‐Ru Ge +7 more
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BioMed Research International, 2011 Psoriasis is a chronic condition of the skin characterised by distinctive scaly plaques. The immune system is now thought to play a major role in the development and pathogenesis of psoriasis with immune cells and cytokines influencing keratinocyte function.
Dunphy, Sinéad, Gardiner, Clair M.
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Journal of Translational Medicine, 2021 Background Natural killer (NK) cells mediate the anti-tumoral immune response as an important component of innate immunity. The aim of this study was to investigate the prognostic significance and functional implication of NK cell-associated surface ...
Hee Young Na +9 more
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Development of Murine Hepatic NK Cells during Ontogeny: Comparison with Spleen NK Cells
Clinical and Developmental Immunology, 2012 The phenotype of developing liver NK cells (CD3−NK1.1+) was investigated during mouse ontogeny comparing with spleen NK cells. The highest percentage of hepatic CD27−CD11b− NK cells occurred at the fetal stage.
Xian Wu +4 more
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