Results 41 to 50 of about 582,983 (289)

Expression of CD226 is associated to but not required for NK cell education [PDF]

, 2017
DNAX accessory molecule-1 (DNAM-1, also known as CD226) is an activating receptor expressed on subsets of natural killer (NK) and T cells, interacts with its ligands CD155 or CD112, and has co-varied expression with inhibitory receptors. Since inhibitory
Bernhardt, Günter, Brodin, Petter, Chambers, Benedict J, Colonna, Marco, Gilfillan, Susan, Höglund, Petter, Kadri, Nadir, Kärre, Klas, Snäll, Johanna, Wagner, Arnika K   +9 more
core   +2 more sources

NK cell-based tumor immunotherapy

Bioactive Materials
Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-infected cells and tumor cells. They are particularly powerful for elimination of hematological cancers, and have attracted considerable interests for therapy of ...
Hao Zhang, Li Yang, Tingting Wang, Zhen Li   +3 more
doaj   +1 more source

A four-stage model for murine natural killer cell development in vivo

Journal of Hematology & Oncology, 2022
Natural killer (NK) cells are the predominant innate lymphoid cells that mediate anti-viral and anti-tumor immunity. NK cells arise from hematopoietic stem cells in the bone marrow (BM) and undergo lineage specification and maturation.
Shoubao Ma, Michael A. Caligiuri, Jianhua Yu   +2 more
doaj   +1 more source

Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming [PDF]

, 2018
Natural Killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated.
Angela Santoni, Angela Santoni, Angela Santoni, Chiara Pighi, Cristina Capuano, Gabriella Palmieri, Lavinia Franchitti, Ombretta Turriziani, Ricciarda Galandrini, Simone Battella, Stefania Morrone   +10 more
core   +2 more sources

Functional crosstalk and regulation of natural killer cells in tumor microenvironment: Significance and potential therapeutic strategies

Genes and Diseases, 2023
Natural killer (NK) cells eliminate a large variety of tumor cells and abnormal cells. However, NK cells in the tumor microenvironment (TME) are often functionally depleted. A few subsets of NK cells even promote tumor growth.
Liping Wang, Zhe Chen, Guohong Liu, Yunbao Pan   +3 more
doaj   +1 more source

Effector Functions of Natural Killer Cell Subsets in the Control of Hematological Malignancies. [PDF]

, 2015
Treatment of hematological malignant disorders has been improved over the last years, but high relapse rate mainly attributable to the presence of minimal residual disease still persists.
Biassoni, Biron, Björklund, Brodin, Bryceson, Burns, Campbell, Cooley, Cooper, Cooper, Curti, Davies, Di Santo, Di Santo, Farag, Fehniger, Fogler, Foley, Freud, Gasser, Gilfillan, Grimm, Guethlein, Herberman, Huntington, Joncker, Kiessling, Killig, King, Kröger, Lajoie, Lanier, Leong, Ljunggren, Lowe, Lundqvist, Mancusi, McQueen, Miller, Moretta, Moretta, Moretta, Nguyen, Oevermann, Ouyang, Perussia, Phillips, Romagnani, Romee, Rosenberg, Rosenberg, Rosenberg, Ruggeri, Santoni, Stabile, Stabile, Stern, Stringaris, Thielens, Torelli, Trinchieri, Trinchieri, Vago, Valés-Gómez, Venstrom, Vivier, Whitelaw, Zorn   +67 more
core   +1 more source

Overview of Strategies to Improve Therapy against Tumors Using Natural Killer Cell

Journal of Immunology Research, 2020
NK cells are lymphocytes with antitumor properties and can directly lyse tumor cells in a non-MHC-restricted manner. However, the tumor microenvironment affects the immune function of NK cells, which leads to immune evasion.
Chaopin Yang, Yue Li, Yaozhang Yang, Zhiyi Chen   +3 more
doaj   +1 more source

On‐Chip Biogenesis of Circulating NK Cell‐Derived Exosomes in Non‐Small Cell Lung Cancer Exhibits Antitumoral Activity

Advanced Science, 2021
As the recognition between natural killer (NK) cells and cancer cells does not require antigen presentation, NK cells are being actively studied for use in adoptive cell therapies in the rapidly evolving armamentarium of cancer immunotherapy. In addition
Yoon‐Tae Kang, Zeqi Niu, Thomas Hadlock, Emma Purcell, Ting‐Wen Lo, Mina Zeinali, Sarah Owen, Venkateshwar G. Keshamouni, Rishindra Reddy, Nithya Ramnath, Sunitha Nagrath   +10 more
doaj   +1 more source

Natural Killer Cells Generated From Human Induced Pluripotent Stem Cells Mature to CD56brightCD16+NKp80+/-In-Vitro and Express KIR2DL2/DL3 and KIR3DL1

Frontiers in Immunology, 2021
The differentiation of human induced pluripotent stem cells (hiPSCs) into T and natural killer (NK) lymphocytes opens novel possibilities for developmental studies of immune cells and in-vitro generation of cell therapy products.
Johanna Euchner, Johanna Euchner, Jasmin Sprissler, Jasmin Sprissler, Toni Cathomen, Toni Cathomen, Daniel Fürst, Daniel Fürst, Hubert Schrezenmeier, Hubert Schrezenmeier, Klaus-Michael Debatin, Klaus Schwarz, Klaus Schwarz, Kerstin Felgentreff   +13 more
doaj   +1 more source

Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]

, 2012
Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Bower, Mark, Gazzard, Brian G, Goodier, Martin R, Gregson, John NS, Kuri-Cervantes, Leticia, Mela, Christopher M   +5 more
core   +1 more source