Results 181 to 190 of about 10,422 (209)

NKCC1 transporter facilitates seizures in the developing brain

Nature Medicine, 2005
During development, activation of Cl(-)-permeable GABA(A) receptors (GABA(A)-R) excites neurons as a result of elevated intracellular Cl(-) levels and a depolarized Cl(-) equilibrium potential (E(Cl)). GABA becomes inhibitory as net outward neuronal transport of Cl(-) develops in a caudal-rostral progression.
Timothy Benke, Audrey C Brumback, Eric Delpire   +2 more
exaly   +3 more sources

Localization of NKCC1 in the cochlea and morphology of the cochlea in NKCC1-knockout mice

Journal of Huazhong University of Science and Technology [Medical Sciences], 2006
The distribution of the Na-K-2Cl co-transporter (NKCC1) in the cochlear K+ cycling pathway in cochlea and cochlear histological changes in the NKCC1 knockout mice were investigated. By using immunohistochemistry and toluidine blue staining, the localization of NKCC1 in cochlea of the C57BL/6J mice and the cochlear histological changes in the NKCC1 ...
Hanqi, Chu, Hao, Xiong, Xiaoqin, Zhou, Xiaowen, Huang, Liangqiang, Zhou, Yonghua, Cui   +5 more
openaire   +2 more sources

Structure and mechanism of the cation–chloride cotransporter NKCC1 [PDF]

Nature, 2019
Cation-chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or sodium across the membrane. They have critical roles in regulating cell volume, controlling ion absorption and secretion across epithelia, and maintaining intracellular chloride homeostasis.
Benjamin J Orlando, jinru zhang, Naomi R Latorraca   +2 more
exaly   +4 more sources

Intestinal ion transport in NKCC1-deficient mice

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000
The Na+-K+-2Cl−cotransporter (NKCC1) located on the basolateral membrane of intestinal epithelia has been postulated to be the major basolateral Cl−entry pathway. With targeted mutagenesis, mice deficient in the NKCC1 protein were generated. The basal short-circuit current did not differ between normal and NKCC1 −/− jejuna.
B R, Grubb, E, Lee, A J, Pace, B H, Koller, R C, Boucher   +4 more
openaire   +2 more sources

Novel scaffolds of key regulators of NKCC1

The FASEB Journal, 2007
Recent work from our laboratory has identified an association between the widely expressed NKCC1 and two Ste20p‐like serine/threonine kinases, SPAK and OSR1. Activation of the widely expressed NKCC1 is mediated by SPAK/OSR1 phosphorylation.
Kenneth B. Gagnon, Roger England, Lisa Diehl, Eric Delpire   +3 more
openaire   +1 more source

Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs

Naunyn-Schmiedeberg's Archives of Pharmacology, 2002
It is generally assumed that bumetanide possesses some selectivity for the renal Na-K-Cl cotransporter NKCC2, although the results are scarce in the literature and comparisons were done with extra-renal NKCC1 at its basal, almost silent state. Here we investigated NKCC2/NKCC1 selectivity of loop diuretic drugs (bumetanide, piretanide and furosemide) as
P, Hannaert, M, Alvarez-Guerra, D, Pirot, C, Nazaret, R P, Garay   +4 more
exaly   +3 more sources

NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders

Trends in Neurosciences, 2017
In physiological conditions, adult neurons have low intracellular Cl- [(Cl-)I] levels underlying the γ-aminobutyric acid (GABA)ergic inhibitory drive. In contrast, neurons have high (Cl-)I levels and excitatory GABA actions in a wide range of pathological conditions including spinal cord lesions, chronic pain, brain trauma, cerebrovascular infarcts ...
Yehezkel Ben-Ari
exaly   +3 more sources

NKCC1 in human diseases: is the SLC12A2 gene haploinsufficient?

American Journal of Physiology-Cell Physiology, 2023
Mutations in the SLC12A2 gene, which encodes the Na-K-2Cl cotransporter-1 (NKCC1), are linked to various conditions such as neurodevelopmental deficits, deafness, and fluid secretion in different epithelia. Cases of complete NKCC1 deficiency in young patients are straightforward, leading to clinical presentations that overlap with the phenotypes ...
Eric Delpire, Rainelli Koumangoye
openaire   +2 more sources

Ultrastructure of the inner ear of NKCC1-deficient mice

Hearing Research, 2001
The transduction of the auditory signal is dependent on the flow of ions within the inner ear. We have generated mice deficient in NKCC1, an ion cotransporter that is thought to be involved in the secretion of K+ by the strial marginal cells. Inner ear histology revealed partial to almost total absence of the scala media and collapse of Reissner's ...
A J, Pace, V J, Madden, O W, Henson, B H, Koller, M M, Henson   +4 more
openaire   +2 more sources

Alterations in airway ion transport in NKCC1-deficient mice

American Journal of Physiology-Cell Physiology, 2001
Airways of Na+-K+-2Cl−(NKCC1)-deficient mice (−/−) were studied in Ussing chambers to determine the role of the basolateral NKCC1 in transepithelial anion secretion. The basal short-circuit current ( I sc) of tracheae and bronchi from adult mice did not differ between NKCC1−/− and normal mice, whereas NKCC1−/− tracheae from neonatal mice exhibited a ...
B R, Grubb, A J, Pace, E, Lee, B H, Koller, R C, Boucher   +4 more
openaire   +2 more sources