Results 181 to 190 of about 8,301 (197)

Synthesis of Bumetanide derivatives and their effects on NKCC1

2020
Das Hauptziel dieser Diplomarbeit war es, Bumetanid (BTN)-Derivate herzustellen. Die neu gewonnenen Derivate sollten die Blut-Hirn-Schranke besser durchdringen als Bumetanid. Es ist bekannt, dass BTN aufgrund seiner Pharmakokinetik die Bluthirnschranke nur zu 1-2% passiert. Bis zu 98% von BTN sind im Plasma gebunden.
openaire   +1 more source

Sex Differences in the Chloride Cotransporters, NKCC1 and KCC2, in the Developing Hypothalamus

Journal of Neuroendocrinology, 2007
In immature neurones, high basal [Cl–]i results in membrane depolarisation following GABAA receptor activation, which is critical for various developmental processes including steroid‐mediated sexual differentiation of the hypothalamus. Previously, we demonstrated that oestradiol enhances GABA‐mediated Ca2+ influx in neonate hypothalamus and that Ca2 ...
T S, Perrot-Sinal, C J, Sinal, J C, Reader, D B, Speert, M M, McCarthy   +4 more
openaire   +2 more sources

Expression patterns of NKCC1 in neurons and non-neuronal cells during cortico-hippocampal development

Cerebral Cortex, 2023
Hovatta Iiris, Hübner Christian A, Kaila Kai   +2 more
exaly  

Cryo‐EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity

EMBO Journal, 2022
Caroline Neumann, Lena Lindtoft Rosenbæk, Rasmus Kock Flygaard   +2 more
exaly  

NKCC1 and Brain Maturation

2013
C.K. Pfeffer, C.A. Hübner
openaire   +1 more source

Selective NKCC1 Inhibitors for the Treatment of Neurodevelopmental and Neurological Disorders with Defective NKCC1/KCC2 expression-ratio (P2-12.003)

Neurology, 2023
Annalisa Savardi, Marco Borgogno, Marco De Vivo, Laura Cancedda   +3 more
openaire   +1 more source

Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs

Naunyn-Schmiedeberg's Archives of Pharmacology, 2002
M Alvarez-Guerra, C Nazaret, Ricardo P Garay   +2 more
exaly  

Molecular mechanism of degradation and turnover of NKCC1

Proceedings of Annual Meeting of the Physiological Society of Japan, 2008
Nakajima, Ken-ichi, Niisato, Naomi, Marunaka, Yoshinori   +2 more
openaire   +1 more source

Dietary Salt Intake Regulates WNK3–SPAK–NKCC1 Phosphorylation Cascade in Mouse Aorta Through Angiotensin II

Hypertension, 2013
Moko Zeniya, Eisei Sohara, Satomi Kita   +2 more
exaly  

WNK-Cab39-NKCC1 signaling increases the susceptibility to ischemic brain damage in hypertensive rats

Journal of Cerebral Blood Flow and Metabolism, 2017
Mohammad Iqbal Hossain Bhuiyan, Shanshan Song, Gulnaz Begum   +2 more
exaly