Results 171 to 180 of about 10,422 (209)

Blockade of calcium-activated chloride channel ANO1 ameliorates ionizing radiation-induced intestinal injury. [PDF]

J Adv Res
Guo Y, Yuan T, Wang Y, Xia L, Zhang J, Fan S.   +5 more
europepmc   +1 more source

Comparative study of feline spinal cord tumors for distinction between peripheral nerve sheath tumor and meningioma. [PDF]

J Vet Med Sci
Saito R, Chambers JK, Uchida K.
europepmc   +1 more source

Altered GABAergic signaling and chloride homeostasis in eye movement circuits during late neurodevelopment: implications for Alzheimer's disease therapy. [PDF]

Front Pharmacol
Porcher C, Rivera C, Medina I, Koric L.
europepmc   +1 more source

Impact of GABA and nutritional supplements on neurochemical biomarkers in autism: a PPA rodent model study. [PDF]

Front Mol Neurosci
Alabdali AN, Ben Bacha A, Alonazi M, Abuaish S, Almotairi A, Al-Ayadhi L, El-Ansary AK.   +6 more
europepmc   +1 more source

The Role of GABA and Its Receptors in Temporal Lobe Epilepsy. [PDF]

Biomolecules
Sperk G, Pirker S.
europepmc   +1 more source

CNS pharmacology of NKCC1 inhibitors

Neuropharmacology, 2022
The Na-K-2Cl cotransporter NKCC1 and the neuron-specific K-Cl cotransporter KCC2 are considered attractive CNS drug targets because altered neuronal chloride regulation and consequent effects on GABAergic signaling have been implicated in numerous CNS disorders.
Wolfgang Löscher, Kai Kaila
exaly   +5 more sources

Pharmacological tools to target NKCC1 in brain disorders [PDF]

Trends in Pharmacological Sciences, 2021
The chloride importer NKCC1 and the chloride exporter KCC2 are key regulators of neuronal chloride concentration. A defective NKCC1/KCC2 expression ratio is associated with several brain disorders. Preclinical/clinical studies have shown that NKCC1 inhibition by the United States FDA-approved diuretic bumetanide is a potential therapeutic strategy in ...
Annalisa Savardi, Marco Borgogno, Marco De Vivo   +2 more
exaly   +3 more sources

Increased NKCC1 expression in refractory human epilepsy

Epilepsy Research, 2007
Cation-chloride co-transporters (CCTs), particularly NKCC1, may be important in epileptogenesis. We have performed a detailed histological examination of NKCC1 in large samples of patients with hippocampal sclerosis (HS) or focal cortical dysplasia (FCD), pathologies both commonly associated with pharmacoresistant epilepsy.
Arjune Sen, Maria Thom, Sanjay M Sisodiya   +2 more
exaly   +3 more sources