Results 191 to 200 of about 10,422 (209)
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Alternative renin regulatory pathways and the NKCC1 isoform
American Journal of Physiology-Renal Physiology, 2005the macula densa is one of the classic regulatory pathways that control the release of renin from the juxtaglomerular cells ([11][1]). It senses the distal luminal NaCl concentration in the thick ascending limb and sends a signal to increase renin secretion in response to sustained decreases ...
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Essential role of NKCC1 in NGF-induced neurite outgrowth
Biochemical and Biophysical Research Communications, 2007The Na(+)/K(+)/2Cl(-) cotransporter (NKCC) mediates electroneutral transport of 2Cl(-) coupled with Na(+) and K(+) across the plasma membrane, and plays crucial roles in Cl(-) uptake into the cells, homeostasis of cellular Cl(-), and cell volume regulation.
Ken-ichi, Nakajima +3 more
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Activation of AMPK reduces the co-transporter activity of NKCC1
Molecular Membrane Biology, 2014The co-transporter activity of Na(+)-K(+)-2Cl(-) 1 (NKCC1) is dependent on phosphorylation. In this study we show the energy-sensing kinase AMPK inhibits NKCC1 activity. Three separate AMPK activators (AICAR, Phenformin and A-769662) inhibited NKCC1 flux in a variety of nucleated cells. Treatment with A-769662 resulted in a reduction of NKCC1(T212/T217)
Fraser, Scott A. +9 more
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Hypotension inNKCC1null mice: role of the kidneys
American Journal of Physiology-Renal Physiology, 2006NKCC1 null mice are hypotensive, in part, from the absence of NKCC1-mediated vasoconstriction. Whether these mice have renal defects in NaCl and water handling which contribute to the hypotension is unexplored. Therefore, we asked 1) whether NKCC1 ( −/−) mice have a defect in the regulation of NaCl and water balance, which might contribute to the ...
Susan M, Wall +12 more
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A Novel Small Molecule Targets NKCC1 To Restore Synaptic Inhibition
Trends in Pharmacological Sciences, 2020Finely tuned excitation-inhibition balance is essential for proper brain function, and loss of balance resulting from reduced synaptic inhibition is associated with neurological disorders. Savardi and colleagues have discovered a novel inhibitor of a cation-chloride transporter that is required for synaptic inhibition, and which restores behaviors ...
Vineeth A, Raveendran +2 more
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Kinase docking to NKCC1 is essential for function
The FASEB Journal, 2007The secretory Na‐K‐2Cl cotransporter, NKCC1, is highly expressed on the basolateral membrane of Cl − ‐secreting epithelia such as salivary, sweat and lacrimal glands as well as lung, stomach, colon, where it participates to salt/fluid secretion.
Kenneth B. Gagnon +2 more
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NKCC1 a Regulator of Glioblastoma Progression
Abstract Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, with poor prognosis despite multimodal therapy. Chloride cotransporters NKCC1 and KCC2 are key regulators of intracellular chloride levels and thereby determine whether GABA acts inhibitory or excitatory.Anja Thomsen +5 more
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Cryo‐EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity
EMBO Journal, 2022Caroline Neumann +2 more
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