Results 161 to 170 of about 8,301 (197)

NKCC1 in human diseases: is the SLC12A2 gene haploinsufficient?

American Journal of Physiology-Cell Physiology, 2023
Mutations in the SLC12A2 gene, which encodes the Na-K-2Cl cotransporter-1 (NKCC1), are linked to various conditions such as neurodevelopmental deficits, deafness, and fluid secretion in different epithelia. Cases of complete NKCC1 deficiency in young patients are straightforward, leading to clinical presentations that overlap with the phenotypes ...
Eric Delpire, Rainelli Koumangoye
openaire   +3 more sources

A limited role of NKCC1 in telencephalic glutamatergic neurons for developing hippocampal network dynamics and behavior

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Neuronal circuits develop in an activity-dependent manner. In vitro data suggest that the intracellular accumulation of chloride—a universal characteristic of immature nerve cells—drives network maturation through a depolarizing action of ...
Jürgen Graf, Chuanqiang Zhang, Stephan Lawrence Marguet   +2 more
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Sevoflurane induces neurotoxic effects on developing neurons through the WNK1/NKCC1/Ca2+/Drp‐1 signalling pathway

Clinical and Experimental Pharmacology and Physiology, 2023
Children repeatedly exposed to anaesthesia have a high risk of cognitive impairment, but the mechanism of its regulation in this context is unknown. The objective of this study was to investigate the possible toxic mechanism of sevoflurane through the ...
Yafan Bai, Wen-Jing Li, Yu-Wei Ji, L. An, Li Zhang, Jun-Fa Li   +5 more
semanticscholar   +1 more source

Alteration of GABAergic neurons and abnormality of NKCC1/KCC2 in focal cortical dysplasia (FCD) type Ⅱ lesions.

Epilepsy Research, 2023
BACKGROUND The current conclusions of molecular genetics still cannot satisfactorily explain the pathogenesis of focal cortical dysplasia (FCD) and the reason for drug resistance. The interneurons of GABA deserve attention.
Li Yan, Yunlin Li, Yongli Liu, Wei-wei Zhang, Piao Yue-shan   +4 more
semanticscholar   +1 more source

Localization of NKCC1 in the cochlea and morphology of the cochlea in NKCC1-knockout mice

Journal of Huazhong University of Science and Technology [Medical Sciences], 2006
The distribution of the Na-K-2Cl co-transporter (NKCC1) in the cochlear K+ cycling pathway in cochlea and cochlear histological changes in the NKCC1 knockout mice were investigated. By using immunohistochemistry and toluidine blue staining, the localization of NKCC1 in cochlea of the C57BL/6J mice and the cochlear histological changes in the NKCC1 ...
Hanqi, Chu, Hao, Xiong, Xiaoqin, Zhou, Xiaowen, Huang, Liangqiang, Zhou, Yonghua, Cui   +5 more
openaire   +2 more sources

Ultrastructure of the inner ear of NKCC1-deficient mice

Hearing Research, 2001
The transduction of the auditory signal is dependent on the flow of ions within the inner ear. We have generated mice deficient in NKCC1, an ion cotransporter that is thought to be involved in the secretion of K+ by the strial marginal cells. Inner ear histology revealed partial to almost total absence of the scala media and collapse of Reissner's ...
A J, Pace, V J, Madden, O W, Henson, B H, Koller, M M, Henson   +4 more
openaire   +2 more sources

Attenuation of Blood–Brain Barrier Disruption in Traumatic Brain Injury via Inhibition of NKCC1 Cotransporter: Insights into the NF-κB/NLRP3 Signaling Pathway

Journal of Neurotrauma
Following traumatic brain injury (TBI), inhibition of the Na+-K+-Cl− cotransporter1 (NKCC1) has been observed to alleviate damage to the blood–brain barrier (BBB). However, the underlying mechanism for this effect remains unclear.
Zehan Zhang, Hui Wang, Bi-ying Tao, Xudong Shi, Guilin Chen, Hengchao Ma, Ruiyun Peng, Jun Zhang   +7 more
semanticscholar   +1 more source

NKCC1 transporter facilitates seizures in the developing brain

Nature Medicine, 2005
During development, activation of Cl(-)-permeable GABA(A) receptors (GABA(A)-R) excites neurons as a result of elevated intracellular Cl(-) levels and a depolarized Cl(-) equilibrium potential (E(Cl)). GABA becomes inhibitory as net outward neuronal transport of Cl(-) develops in a caudal-rostral progression.
Volodymyr I, Dzhala, Delia M, Talos, Dan A, Sdrulla, Audrey C, Brumback, Gregory C, Mathews, Timothy A, Benke, Eric, Delpire, Frances E, Jensen, Kevin J, Staley   +8 more
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Intestinal ion transport in NKCC1-deficient mice

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2000
The Na+-K+-2Cl−cotransporter (NKCC1) located on the basolateral membrane of intestinal epithelia has been postulated to be the major basolateral Cl−entry pathway. With targeted mutagenesis, mice deficient in the NKCC1 protein were generated. The basal short-circuit current did not differ between normal and NKCC1 −/− jejuna.
B R, Grubb, E, Lee, A J, Pace, B H, Koller, R C, Boucher   +4 more
openaire   +2 more sources

The NKCC1 Inhibitor Bumetanide Restores Cortical Feedforward Inhibition and Lessens Sensory Hypersensitivity in Early Postnatal Fragile X Mice

Biological Psychiatry
BACKGROUND: Exaggerated responses to sensory stimuli, a hallmark of fragile X syndrome, contribute to anxiety and learning challenges. Sensory hypersensitivity is recapitulated in the Fmr1 knockout (KO) mouse model of fragile X syndrome.
Nazim Kourdougli, Toshihiro Nomura, Michelle W. Wu, A. Heuvelmans, Zoë Dobler, A. Contractor, C. Portera-Cailliau   +6 more
semanticscholar   +1 more source