Results 1 to 10 of about 18,959 (165)

Anti-NLRP3 Inflammasome Natural Compounds: An Update [PDF]

Biomedicines, 2021
The nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome is a multimeric protein complex that recognizes various danger or stress signals from pathogens, the host, and the environment ...
Baolong Liu, Jiujiu Yu
doaj   +3 more sources

Metformin Inhibits NLR Family Pyrin Domain Containing 3 (NLRP)-Relevant Neuroinflammation via an Adenosine-5′-Monophosphate-Activated Protein Kinase (AMPK)-Dependent Pathway to Alleviate Early Brain Injury After Subarachnoid Hemorrhage in Mice

Frontiers in Pharmacology, 2022
Neuroinflammation plays a key role in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies have shown that metformin exerts anti-inflammatory effects and promotes functional recovery in various central ...
Lei Jin, Fa Jin, Shenquan Guo, Wenchao Liu, Boyang Wei, Haiyan Fan, Guangxu Li, Xin Zhang, Shixing Su, Ran Li, Dazhao Fang, Chuanzhi Duan, Xifeng Li   +12 more
doaj   +3 more sources

Effect of Heat Stress on the Expression of Circulating Cyto(chemo)kine and Inflammatory Markers in Broiler Chickens Selected for High- or Low-water Efficiency [PDF]

Frontiers in Bioscience-Landmark
Background: Water scarcity is a current, significant global concern that will only increase under the pressure of climate change. Improving water efficiency of poultry is a new and promising area to help temper agriculture's future ...
Elizabeth S. Greene, Travis Tabler, Walter G. Bottje, Sara Orlowski, Sami Dridi   +4 more
doaj   +3 more sources

Treadmill training attenuates pyroptosis in rats with cerebral ischemia/reperfusion injury [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Few studies have investigated the mechanism by which exercise training promotes neural repair during rehabilitation after stroke. In this study, we evaluated the neuroprotective effects of exercise training and pyroptosis-associated factors
Fang Luo, Mingjin Zhu, Kunkun Lv, Di Sun, Guifen Yang, Guoyuan Pan   +5 more
doaj   +1 more source

PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway [PDF]

Frontiers in Aging Neuroscience, 2021
A classical hallmark of Parkinson’s disease (PD) pathogenesis is the accumulation of misfolded alpha-synuclein (αSyn) within Lewy bodies and Lewy neurites, although its role in microglial dysfunction and resultant dopaminergic (DAergic) neurotoxicity is still elusive.
Anumantha G. Kanthasamy, Huajun Jin, Sireesha Manne, Bharathi N. Palanisamy, Alejandra Bargues-Carot, Manikandan Samidurai, Gary Zenitsky, Vellareddy Anantharam, Arthi Kanthasamy, Naveen Kondru, Monica Hepker   +10 more
openaire   +3 more sources

Identification of mutations in the PYRIN-containing NLR genes (NLRP) in head and neck squamous cell carcinoma [PDF]

, 2014
Head and Neck Squamous Cell Carcinoma (HNSCC) encompasses malignancies that arise in the mucosa of the upper aerodigestive tract. Recent high throughput DNA sequencing revealed HNSCC genes mutations that contribute to several cancer cell characteristics,
A Mashberg, Ann Marie Egloff, BK Davis, BW Neville, CB Moore, D Hanahan, E Elinav, E Meyer, E White, EA Collisson, GY Chen, HS van Monsjou, IC Allen, IC Allen, J Ahn, J Ferlay, Jennifer R. Grandis, JH Meurman, JP Ting, JP Ting, JP Ting, KK Ang, KV Woods, M Lamkanfi, MA O'Rorke, MH Zaki, MH Zaki, MH Zaki, MS Meyer, Muy-Teck Teh, N Agrawal, N Jounai, N Stransky, R Cooney, R Pries, R Slim, S Nik-Zainal, S Nik-Zainal, S Normand, T Strowig, V Brailo, Vivian W. Y. Lui, Y Lei, Y Lei, Yu Lei   +44 more
core   +16 more sources

Protective effect of Guanxin Danshen formula on myocardial ischemiareperfusion injury in rats

Acta Cirúrgica Brasileira, 2023
Purpose: Myocardial ischemia/reperfusion injury (MIRI) leads to myocardial tissue necrosis, which will increase the size of myocardial infarction. The study examined the protective effect and mechanism of the Guanxin Danshen formula (GXDSF) on MIRI in ...
Lanfang Li, Bo Liu, Min Wang, Jingxue Ye, Guibo Sun   +4 more
doaj   +1 more source

Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation

Acta Cirúrgica Brasileira, 2022
Purpose: Tanshinone IIA is a well-known lipophilic active constituent refined from traditional Chinese medicines, danshen. It has been previously demonstrated to possess various biological properties, including anti-inflammatory, antioxidant, promoting ...
Dan Li, Zhihui Yang, Shan Gao, Hao Zhang, Guanwei Fan   +4 more
doaj   +1 more source

Paeoniflorin mitigates PBC-induced liver fibrosis by repressing NLRP3 formation

Acta Cirúrgica Brasileira, 2022
Purpose: To delve into the influence of paeoniflorin (PA) on abating primary biliary cholangitis (PBC)-induced liver fibrosis and its causative role. Methods: Our team allocated the mice to control group, PA group, PBC group and PBC+PA group.
Yizhe Zhang, Shujie Zhang, Xin Luo, Han Zhao, Xiaoxing Xiang   +4 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source