Results 1 to 10 of about 21,899 (194)

Multiorgan characterization of inflammasome component expression in a rat model of advanced heart failure [PDF]

ESC Heart Failure
Aims Targeting inflammasomes in heart failure (HF) might represent a novel therapeutic option. Nevertheless, previous studies focused only on myocardial inflammasome alterations, and data are scarce regarding their regulation and role in HF‐associated ...
Dávid Nagy, Zsófia Onódi, Márton Kocsis, Artúr Tóth, Tímea Bálint, Attila Oláh, Alex Ali Sayour, Bálint András Barta, Béla Merkely, Péter Ferdinandy, Tamás Radovits, Zoltán V. Varga, Mihály Ruppert   +12 more
doaj   +2 more sources

Placental inflammation is increased in gestational diabetes mellitus: The role of inflammasome NLRP-3 and chemokine scavenger decoy receptor D6. [PDF]

PLoS ONE
BackgroundGestational diabetes mellitus is characterized by low-grade systemic inflammation. Placental inflammation in gestation diabetes mellitus has not been extensively investigated yet.ObjectivesAims of this study were to analyze: a) serum levels of ...
Marianna Onori, Giuliana Beneduce, Filomena Colella, Donatella Lucchetti, Caterina Policola, Vincenzo Arena, Fabio Sannino, Alessandro Petrecca, Dario Pitocco, Alfredo Pontecorvi, Alessandro Sgambato, Giovanni Scambia, Nicoletta Di Simone, Tullio Ghi, Chiara Tersigni   +14 more
doaj   +2 more sources

Jiedutongluotiaogan Formula Improves Pancreatic Dysfunction in db/db Mice through Modulating the Gut Microbiota-Short Chain Fatty Acids-NLR Family, Pyrin Domain–Containing Protein 3 Inflammasome

World Journal of Traditional Chinese Medicine
Objective: Disturbance of gut microbiota plays an essential role in metabolic diseases, such as diabetes. Jiedutongluotiaogan formula (JTTF) was designed to meliorate the symptoms of type 2 diabetes.
Jin-Li Luo, Wen-Qi Jin, Li Wang, Qi Zhang, Yu Wang, Cui Wu, Yue Qu, Yu-Ting Peng, Li-Wei Sun, Chun-Li Piao   +9 more
doaj   +2 more sources

Treadmill training attenuates pyroptosis in rats with cerebral ischemia/reperfusion injury [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Few studies have investigated the mechanism by which exercise training promotes neural repair during rehabilitation after stroke. In this study, we evaluated the neuroprotective effects of exercise training and pyroptosis-associated factors
Fang Luo, Mingjin Zhu, Kunkun Lv, Di Sun, Guifen Yang, Guoyuan Pan   +5 more
doaj   +1 more source

PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway [PDF]

Frontiers in Aging Neuroscience, 2021
A classical hallmark of Parkinson’s disease (PD) pathogenesis is the accumulation of misfolded alpha-synuclein (αSyn) within Lewy bodies and Lewy neurites, although its role in microglial dysfunction and resultant dopaminergic (DAergic) neurotoxicity is still elusive.
Manikandan Samidurai, Bharathi N. Palanisamy, Alejandra Bargues-Carot, Monica Hepker, Naveen Kondru, Sireesha Manne, Gary Zenitsky, Huajun Jin, Vellareddy Anantharam, Anumantha G. Kanthasamy, Arthi Kanthasamy   +10 more
openaire   +3 more sources

Protective effect of Guanxin Danshen formula on myocardial ischemiareperfusion injury in rats

Acta Cirúrgica Brasileira, 2023
Purpose: Myocardial ischemia/reperfusion injury (MIRI) leads to myocardial tissue necrosis, which will increase the size of myocardial infarction. The study examined the protective effect and mechanism of the Guanxin Danshen formula (GXDSF) on MIRI in ...
Lanfang Li, Bo Liu, Min Wang, Jingxue Ye, Guibo Sun   +4 more
doaj   +1 more source

Tanshinone IIA ameliorates myocardial ischemia/reperfusion injury in rats by regulation of NLRP3 inflammasome activation and Th17 cells differentiation

Acta Cirúrgica Brasileira, 2022
Purpose: Tanshinone IIA is a well-known lipophilic active constituent refined from traditional Chinese medicines, danshen. It has been previously demonstrated to possess various biological properties, including anti-inflammatory, antioxidant, promoting ...
Dan Li, Zhihui Yang, Shan Gao, Hao Zhang, Guanwei Fan   +4 more
doaj   +1 more source

Effect of Er Miao San on peritoneal macrophage polarisation through the miRNA-33/NLRP3 signalling pathway in a rat model of adjuvant arthritis

Pharmaceutical Biology, 2022
Context Er Miao San (EMS) is a formulation that contains Atractylodis Rhizoma and Phellodendri Cortex in 1:1 ratio, and is commonly used to treat rheumatoid arthritis (RA) and other inflammatory diseases.Objective We investigated the mechanism of action ...
Min Liu, Xiangwen Meng, Zihua Xuan, Simeng Chen, Jin Wang, Zhiluo Chen, Jiayu Wang, Xiaoyi Jia   +7 more
doaj   +1 more source

NLRP3 inflammasome inhibitor MCC950 can reduce the damage of pancreatic and intestinal barrier function in mice with acute pancreatitis

Acta Cirúrgica Brasileira, 2022
Purpose: Abnormal activation of NOD-like receptor protein 3 (NLRP3) inflammasome can lead to the occurrence and progression of acute pancreatitis. This study investigated the protective effect of MCC950 on pancreatitis mice.
Yanghui Shen, Huobao Yang, Dansen Wu, Hangmei Yang, Donghuang Hong   +4 more
doaj   +1 more source

Puerarin protects renal ischemia-reperfusion injury in rats through NLRP3/Caspase-1/GSDMD pathway

Acta Cirúrgica Brasileira, 2023
Purpose: To observe the effect of puerarin on renal ischemia-reperfusion (I/R) injury in rats, and to explore its mechanism based on NLRP3/Caspase-1/GSDMD pathway.
Kangyu Wang, Zhao Tang, Shuai Liu, Yan Liu, Huiqing Zhang, Haocheng Zhan   +5 more
doaj   +1 more source