Results 181 to 190 of about 26,384,108 (210)

Immune dysregulation in chronic diabetic wounds: therapeutic opportunities for healing reprogramming. [PDF]

Front Immunol
Yu W, Li Q, Wang J, Fu J, Hao Y, Wang Z, Xu H, Zhang M, Zhao G, Ma Y.   +9 more
europepmc   +1 more source

4-Octyl Itaconate Promotes Diabetic Wound Healing by Enhancing Pro-Resolving Macrophages via the Efferocytosis-MCT1-Lactate-GPR132 Pathway and Macrophage-Independent Synergistic Effects (Diabetes Metab J 2026;50:707-23). [PDF]

Diabetes Metab J
Junaid M, Zhu Y.
europepmc   +1 more source

Mast Cells Are a Reservoir of NLRP1 in Human Skin. [PDF]

Int J Mol Sci
Dobre A, Fertig TE, Niculae AM, Cohn AM, Curici A, Andrei RT, Marta DS, Peteu VE, Popescu RG, Marinescu GC, Turcu G, Forsea AM, Ion DA, Gherghiceanu M, Nedelcu RI.   +14 more
europepmc   +1 more source

NLR inflammasome pathways: key targets for pathogenesis and therapy of metabolic diseases. [PDF]

Front Immunol
Zhou J, Yang R, Zhu W, He Z, Ma Y, Feng Z, Yu L.   +6 more
europepmc   +1 more source

Posttranslational Regulation of the NLR Family Pyrin Domain-Containing 3 Inflammasome

Frontiers in Immunology, 2018
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a multi-protein complex that can be activated by a variety of pathogen-associated molecular patterns or damage-associated molecular patterns.
Kwang-Ho Lee, Do-Wan Shim
exaly   +2 more sources

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The Inflammasome NLR Family Pyrin Domain-Containing Protein 3 (NLRP3) as a Novel Therapeutic Target for Idiopathic Pulmonary Fibrosis

The American Journal of Pathology, 2022
Idiopathic pulmonary fibrosis (IPF) is a dramatic disease without cure. The US Food and Drug Administration-approved drugs, pirfenidone and nintedanib, only slow disease progression. The clinical investigation of novel therapeutic approaches for IPF is an unmet clinical need. Nucleotide-binding oligomerization domain-like receptor or NOD-like receptors
Ruben M.L. Colunga Biancatelli, Pavel A. Solopov, John D. Catravas   +2 more
openaire   +2 more sources

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors

Bioorganic & Medicinal Chemistry Letters, 2020
Aberrant activation of NLRP3 inflammasome is present in a subset of acute and chronic inflammatory diseases. The NLRP3 inflammasome has been recognized as an attractive therapeutic target for developing novel and specific anti-inflammatory inhibitors. Cellular structure-activity relationship-guided optimization resulted in the identification of 4-oxo-2-
Yun, Chen, Hongbin, He, Hua, Jiang, Li, Li, Zhiyu, Hu, Huiying, Huang, Qingyan, Xu, Rongbin, Zhou, Xianming, Deng   +8 more
openaire   +2 more sources

Hippo Signaling Controls NLR Family Pyrin Domain Containing 3 Activation and Governs Immunoregulation of Mesenchymal Stem Cells in Mouse Liver Injury [PDF]

Hepatology, 2019
The Hippo pathway, an evolutionarily conserved protein kinase cascade, tightly regulates cell growth and survival. Activation of yes-associated protein (YAP), a downstream effector of the Hippo pathway, has been shown to modulate tissue inflammation ...
Ronald W Busuttil, Bibo Ke
exaly   +2 more sources