Results 161 to 170 of about 22,554 (186)

TET3-overexpressing macrophages are a unifying pathogenic feature with therapeutic potential in chronic inflammatory diseases. [PDF]

J Clin Invest
Haji S, Ogawa Y.
europepmc   +1 more source

Post-translational modifications of NLRP3: to prime or not to prime? [PDF]

Trends Immunol
Dufies O, Zanoni I.
europepmc   +1 more source

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The Inflammasome NLR Family Pyrin Domain-Containing Protein 3 (NLRP3) as a Novel Therapeutic Target for Idiopathic Pulmonary Fibrosis

The American Journal of Pathology, 2022
Idiopathic pulmonary fibrosis (IPF) is a dramatic disease without cure. The US Food and Drug Administration-approved drugs, pirfenidone and nintedanib, only slow disease progression. The clinical investigation of novel therapeutic approaches for IPF is an unmet clinical need. Nucleotide-binding oligomerization domain-like receptor or NOD-like receptors
Ruben M.L. Colunga Biancatelli, Pavel A. Solopov, John D. Catravas   +2 more
openaire   +2 more sources

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors

Bioorganic & Medicinal Chemistry Letters, 2020
Aberrant activation of NLRP3 inflammasome is present in a subset of acute and chronic inflammatory diseases. The NLRP3 inflammasome has been recognized as an attractive therapeutic target for developing novel and specific anti-inflammatory inhibitors. Cellular structure-activity relationship-guided optimization resulted in the identification of 4-oxo-2-
Yun, Chen, Hongbin, He, Hua, Jiang, Li, Li, Zhiyu, Hu, Huiying, Huang, Qingyan, Xu, Rongbin, Zhou, Xianming, Deng   +8 more
openaire   +2 more sources

Imperatorin alleviated NLR family pyrin domain-containing 3 inflammasome cascade-induced synovial fibrosis and synovitis in rats with knee osteoarthritis

Bioengineered, 2021
Haosheng Zhang, Peimin Wang, Zhengquan Huang   +2 more
exaly  

Activated NLR family pyrin domain containing 3 (NLRP3) inflammasome in keratinocytes promotes cutaneous T-cell response in patients with vitiligo

Journal of Allergy and Clinical Immunology, 2020
Shuli Li, Pan Kang, Weigang Zhang
exaly  

Low Potassium Triggers Tubular Epithelial NLR Family Pyrin Domain-Containing 3/Apoptosis-Associated Speck-Like Protein-Containing a CARD–Driven Kidney Inflammation Independently of Inflammasomes

The American Journal of Pathology
Satoko Komori, Takanori Komada, Takayoshi Matsumura, Tadayoshi Karasawa, Yutaka Miura, Chintogtokh Baatarjav, Yoshitaka Gunji, Hidetoshi Aizawa, Yoshiko Mizushina, Noriyoshi Fukushima, Toru Sugihara, Satoshi Ando, Tetsuya Fujimura, Daisuke Nagata, Masafumi Takahashi   +14 more
openaire   +1 more source

NLR family pyrin domain containing 3 (NLRP3) inflammasomes and peripheral neuropathic pain - Emphasis on microRNAs (miRNAs) as important regulators

European Journal of Pharmacology, 2023
Paramita Basu, Camelia Maier, Dayna L Averitt   +2 more
exaly