Results 21 to 30 of about 21,899 (194)

The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways

Medical Science Monitor, 2020
BACKGROUND Protein kinase R (PKR) is implicated in the inflammatory response to bacterial infection while the role of PKR in sepsis-induced acute kidney injury (AKI) is largely unknown. This study aimed to investigate the effects of the specific PKR inhibitor C16 (C13H8N4OS) on lipopolysaccharide (LPS)-induced AKI, and its mechanisms of action ...
Zhou, Jialu, Zhang, Fan, Lin, Hongru, Quan, Minxue, Yang, Yaqin, Lv, Yanni, He, Zongnan, Qian, Yisong   +7 more
openaire   +3 more sources

NLRP3 Inflammasome and Its Critical Role in Gynecological Disorders and Obstetrical Complications

Frontiers in Immunology, 2021
Inflammasomes, intracellular, multimeric protein complexes, are assembled when damage signals stimulate nucleotide-binding oligomerization domain receptors (NLRs).
Xuhui Fang, Yanshi Wang, Yu Zhang, Yelin Li, Joanne Kwak-kim, Joanne Kwak-kim, Li Wu   +6 more
doaj   +1 more source

Shionone Inhibits Glomerular Fibirosis by Suppressing NLRP3 Related Inflammasome though SESN2-NRF2/HO-1 Pathway [PDF]

Diabetes & Metabolism Journal
Background Diabetic nephropathy (DN) is the most common and serious complication of diabetes mellitus. Shionone (SH), an important triterpenoid compound in the root extract of Aster, might exert a protective effect in DN mice and high glucose cultivated ...
Tian Xiao, Hanzhen Zhao, Yucong Wang, Mengyin Chen, Cong Wang, Chen Qiao   +5 more
doaj   +1 more source

Anti-NLRP3 Inflammasome Natural Compounds: An Update

Biomedicines, 2021
The nucleotide-binding domain and leucine-rich repeat related (NLR) family, pyrin domain containing 3 (NLRP3) inflammasome is a multimeric protein complex that recognizes various danger or stress signals from pathogens, the host, and the environment ...
Baolong Liu, Jiujiu Yu
doaj   +1 more source

Novel role of PKR in inflammasome activation and HMGB1 release [PDF]

, 2014
The inflammasome regulates release of caspase activation-dependent cytokines, including IL-1β, IL-18, and high-mobility group box 1 (HMGB1)1-5. During the course of studying HMGB1 release mechanisms, we discovered an important role of double-stranded RNA
Andersson, Ulf, Antoine, Daniel J., Chavan, Sangeeta S., Erlandsson-Harris, Helena, Hotamisligil, Gökhan S., Inouye, Karen, Kalb, Thomas, Li, Jianhua, Lu, Ben, Lundbäck, Peter, Nakamura, Takahisa, Olofsson, Peder S., Roth, Jesse, Tang, Yiting, Ting, Jenny P-Y, Tracey, Kevin J., Valdes-Ferrer, Sergio I, Wang, Haichao, Yang, Huan, Zou, Yongrui   +19 more
core   +1 more source

NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma

Molecular Neurodegeneration, 2020
Background Acute glaucoma, characterized by a sudden elevation in intraocular pressure (IOP) and retinal ganglion cells (RGCs) death, is a major cause of irreversible blindness worldwide that lacks approved effective therapies, validated treatment ...
Hui Chen, Yang Deng, Xiaoliang Gan, Yonghao Li, Wenyong Huang, Lin Lu, Lai Wei, Lishi Su, Jiawen Luo, Bin Zou, Yanhua Hong, Yihai Cao, Yizhi Liu, Wei Chi   +13 more
doaj   +1 more source

Pyroptosis-Mediated Damage Mechanism by Deoxynivalenol in Porcine Small Intestinal Epithelial Cells

Toxins, 2023
Deoxynivalenol (DON) is known as a vomitoxin, which frequently contaminates feedstuffs, such as corn, wheat, and barley. Intake of DON-contaminated feed has been known to cause undesirable effects, including diarrhea, emesis, reduced feed intake ...
Tae Hong Kang, Sangsu Shin, JeongWoong Park, Bo Ram Lee, Sang In Lee   +4 more
doaj   +1 more source

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 [PDF]

, 2015
Inflammation that contributes to acute cerebrovascular disease is driven by the proinflammatory cytokine interleukin-1 and is known to exacerbate resulting injury.
Coutts, G., Cruickshank, S. M., Dénes, Ádám, Lénárt, Nikolett, Pelegrin, P.   +4 more
core   +1 more source

Understanding diversity of human innate immunity receptors: analysis of surface features of leucine-rich repeat domains in NLRs and TLRs. [PDF]

, 2009
BackgroundThe human innate immune system uses a system of extracellular Toll-like receptors (TLRs) and intracellular Nod-like receptors (NLRs) to match the appropriate level of immune response to the level of threat from the current environment.
Godzik, Adam, Istomin, Andrei Y
core   +4 more sources

The Role of NLRP3 Inflammasomes in Trained Immunity

Frontiers in Bioscience-Landmark, 2023
Inflammasomes are cytosolic multi-protein complexes that play an important role in the innate immune system, inducing cytokine maturation and pyroptosis.
Gilyoung Lee, Huijeong Ahn, Eunsong Lee, Geun-Shik Lee   +3 more
doaj   +1 more source