Results 41 to 50 of about 11,495 (207)

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]

, 2010
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S, Datta, Pinaki, Eisenlohr, Laurence, Fernandes-Alnemri, Teresa, Huang, Lan, Juliana, Christine, Kang, Seokwon, Landel, Carlisle P, McCormick, Margaret, McDermott, Erin, Solorzano, Leobaldo, Wu, Jianghong, Yu, Je-Wook   +12 more
core   +3 more sources

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +1 more source

Purinergic neurotransmission receptor P2X4 silencing alleviates intracerebral hemorrhage-induced neuroinflammation by blocking the NLRP1/Caspase-1 pathway

Scientific Reports, 2023
This study is performed to explore the role of P2X4 in intracerebral hemorrhage (ICH) and the association between P2X4 and the NLRP1/Caspase-1 pathway. The mouse ICH model was established via collagenase injection into the right basal ganglia.
Yuanshui Wu, Xiaoli Huang, Le Yang, Yuanjie Liu   +3 more
doaj   +1 more source

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Cytoprotective Activated Protein C Averts Nlrp3 Inflammasome–Induced Ischemia-Reperfusion Injury Via Mtorc1 Inhibition [PDF]

, 2017
Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in ...
Al-Dabet, Moh\u27d Mohanad, Bock, Fabian, Braun-Dullaeus, Ruediger C., Camerer, Eric, Dockendorff, Chris, Elwakiel, Ahmed, Esmon, Charles T., Gadi, Ihsan, Ghosh, Sanchita, Griffin, John H., Huber, Tobias B., Isermann, Berend, Kohli, Shrey, Manoharan, Jayakumar, Nazir, Sumra, Ranjan, Satish, Shahzad, Khurrum   +16 more
core   +2 more sources

07.16 Nlrp1 mutations cause autoinflammatory diseases in human: implication of the nlrp1 inflammasome?

Annals of the Rheumatic Diseases, 2017
Background Inflammation is a vital and complex process in response to diverse tissue damaging stimuli such as trauma, injury and pathogen. NLRP1, NLRP3 and NLRC4 belonging to the intracellular proteins Nod like receptor family, are capable of sensing the inflammatory inducers and trigger the assembly of a large complex called the inflammasome.
Sylvie Grandemange, Elodie Sanchez, Cécile Rittore, Yasamine El Ahmadi, Pascale Louis-Plence, John C Reed, Florence Apparailly, Isabelle Touitou, David Geneviève   +8 more
openaire   +1 more source

A new autoinflammatory and autoimmune syndrome associated with NLRP1 mutations: NAIAD (NLRP1-associated autoinflammation with arthritis and dyskeratosis) [PDF]

Annals of the Rheumatic Diseases, 2017
Inflammasomes are multiprotein complexes that sense pathogens and trigger biological mechanisms to control infection. Nucleotide-binding oligomerisation domain-like receptor (NLR) containing a PYRIN domain 1 (NLRP1), NLRP3 and NLRC4 plays a key role in this innate immune system by directly assembling in inflammasomes and regulating inflammation ...
Grandemange, S., Sanchez, E., Louis-Plence, P., Mau-Them, F.T., Bessis, D., Coubes, C., Frouin, E., Seyger, M.M.B., Girard, M., Puechberty, J., Costes, V., Rodiere, M., Carbasse, A., Jeziorski, E., Portales, P., Sarrabay, G., Mondain, M., Jorgensen, C., Apparailly, F., Hoppenreijs, E.P., Hoppenreijs, E.P., Touitou, I., Genevieve, D.   +22 more
openaire   +2 more sources

Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease

Frontiers in Aging Neuroscience, 2020
Background: There is a significant gender difference in the incidence and symptoms of Alzheimer's disease (AD), but its mechanisms are not completely understood.
Jinghang Zhang, Jinghang Zhang, Lihong Pei, Dan Zang, Yun Xue, Xiaohui Wang, Yiyang Chen, Jinsong Li, Jian Yu, Qingzu Gao, Wenyu Di, Chaochu Cui, Wei Su, Xianwei Wang   +13 more
doaj   +1 more source

Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease

Experimental Gerontology, 2023
Alzheimer's disease (AD) is marked by reduced acetylcholine receptor (AChR) density and an increase in nucleotide oligomerization domain (NOD)-like receptors NLR family, pyrin domain containing 1 (NLRP1).
Z. Gorgin Karaji, M. Fathi, R. Mirnasori, E.A. van der Zee   +3 more
doaj   +1 more source

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 [PDF]

, 2015
Inflammation that contributes to acute cerebrovascular disease is driven by the proinflammatory cytokine interleukin-1 and is known to exacerbate resulting injury.
Coutts, G., Cruickshank, S. M., Dénes, Ádám, Lénárt, Nikolett, Pelegrin, P.   +4 more
core   +1 more source