High p62 expression suppresses the NLRP1 inflammasome and increases stress resistance in cutaneous SCC cells [PDF]
Cell Death and Disease, 2022 NLRP1 is the primary inflammasome sensor in human keratinocytes. Sensing of UVB radiation by NLRP1 is believed to underlie the induction of sunburn.
Paulina Hennig +4 more
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Inhibition of NLRP1 inflammasome improves autophagy dysfunction and Aβ disposition in APP/PS1 mice [PDF]
Behavioral and Brain Functions, 2023 Increasing evidence has shown that the NOD-like receptor protein 1 (NLRP1) inflammasome is associated with Aβ generation and deposition, which contributes to neuronal damage and neuronal-inflammation in Alzheimer's disease (AD).
Xuewang Li +7 more
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Comparison of Different Keratinocyte Cell Line Models for Analysis of NLRP1 Inflammasome Activation [PDF]
BiomoleculesThe NLRP1 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-1) inflammasome is the most important inflammasome in human keratinocytes. It plays a crucial role in regulating innate immunity in the skin.
Tian Wang +2 more
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ZAKα/P38 kinase signaling pathway regulates hematopoiesis by activating the NLRP1 inflammasome [PDF]
EMBO Molecular Medicine, 2023 Chronic inflammatory diseases are associated with hematopoietic lineage bias, including neutrophilia and anemia. We have recently identified that the canonical inflammasome mediates the cleavage of the master erythroid transcription factor GATA1 in ...
Lola Rodríguez‐Ruiz +12 more
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Diverse viral proteases activate the NLRP1 inflammasome [PDF]
eLife, 2021 The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting in degradation of the N-terminal domains of ...
Brian V Tsu +5 more
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TKI-mediated inhibition of NLRP1 inflammasome restores erythropoiesis in DBA syndrome [PDF]
EMBO Molecular MedicineDiamond-Blackfan anemia syndrome (DBAS) is marked by defective erythropoiesis caused by impaired ribosome biogenesis and aberrant signaling. Here, we investigate how ribosomal stress-induced activation of the NLRP1 inflammasome affects erythroid ...
Juan M Lozano-Gil +19 more
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Hippocampal NLRP1 inflammasome mediates anxiety-like behavior in mice with hypothyroidism [PDF]
Scientific ReportsHypothyroidism is associated with anxiety and depression. However, the mechanisms underlying these neuropsychiatric symptoms remain largely unknown. This study aimed to investigate the role of the NLRP1 inflammasome in anxiety-like behavior in mice with ...
Yu-Wei Cheng +9 more
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NLRP1 inflammasome contributes to chronic stress-induced depressive-like behaviors in mice [PDF]
Journal of Neuroinflammation, 2020 Background Major depressive disorder (MDD) is a highly prevalent psychiatric disorder, and inflammation has been considered crucial components of the pathogenesis of depression.
Ao-Qi Song +7 more
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Anti-Inflammasome Effect of Impressic Acid on Diesel Exhaust Particulate Matter-Induced NLRP1 Inflammasome via the Keap1/p62/Nrf2-Signaling Pathway in Keratinocytes [PDF]
AntioxidantsDiesel exhaust particulate (DEP) is widely recognized to weaken lung function and skin diseases. When the skin, which defends against external factors, is exposed to PM2.5, various chronic inflammatory diseases occur. When keratinocytes recognize harmful
Seung Yeon Lee +6 more
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The Ferroptosis-NLRP1 Inflammasome: The Vicious Cycle of an Adverse Pregnancy [PDF]
Frontiers in Cell and Developmental Biology, 2021 One of the hallmarks of placental dysfunction is the increase of oxidative stress. This process, along with the overexpression of the inflammasome, creates a downward spiral that can lead to a series of severe pregnancy complications.
Li Meihe +8 more
doaj +2 more sources