Results 41 to 50 of about 9,154 (185)

NLRP1 Is an Inflammasome Sensor for Toxoplasma gondii [PDF]

Infection and Immunity, 2014
ABSTRACT The obligate intracellular parasite Toxoplasma gondii is able to infect nearly all nucleated cell types of warm-blooded animals. This is achieved through the injection of hundreds of parasite effectors into the host cell cytosol, allowing the parasite to establish a vacuolar niche for growth ...
Sarah E, Ewald, Joseph, Chavarria-Smith, John C, Boothroyd   +2 more
openaire   +2 more sources

Brainiac Caspases: Beyond the Wall of Apoptosis [PDF]

, 2019
For the last two decades, caspases, a family of cysteine-aspartic proteases, have evolved from being considered solely as regulators of apoptosis or inflammation to having a wider range of functions.
Alonso Bellido, Isabel María, Burguillos García, Miguel Ángel, Espinosa Oliva, Ana María, García Revilla, Juan   +3 more
core   +1 more source

Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation

Cell Reports, 2023
NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-terminal (NT) and C-terminal (CT) fragments. The proteasome-mediated degradation of the NT releases the CT from autoinhibition, but the stimuli that trigger NT degradation have not ...
Elizabeth L. Orth-He, Hsin-Che Huang, Sahana D. Rao, Qinghui Wang, Qifeng Chen, Claire M. O’Mara, Ashley J. Chui, Michelle Saoi, Andrew R. Griswold, Abir Bhattacharjee, Daniel P. Ball, Justin R. Cross, Daniel A. Bachovchin   +12 more
openaire   +2 more sources

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

Spinal cord NLRP1 inflammasome contributes to dry skin induced chronic itch in mice

Journal of Neuroinflammation, 2020
Background Dry skin itch is one of the most common skin diseases and elderly people are believed to be particularly prone to it. The inflammasome has been suggested to play an important role in chronic inflammatory disorders including inflammatory skin ...
Jun-Juan Fan, Bo Gao, Ao-Qi Song, Ya-Jing Zhu, Jun Zhou, Wei-Zu Li, Yan-Yan Yin, Wen-Ning Wu   +7 more
doaj   +1 more source

Protective and Aggravating Effects of Nlrp3 Inflammasome Activation in IBD Models: Influence of Genetic and Environmental Factors [PDF]

, 2012
Background: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation due to dysregulation of the mucosal immune system.
Bauer, Christian, Düwell, Peter, Endres, Stefan, Lehr, Hans-Anton, Schnurr, Max   +4 more
core   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources

Celecoxib inhibits NLRP1 inflammasome pathway in MDA-MB-231 Cells. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
AbstractNLRP1 is predominantly overexpressed in breast cancer tissue, and the evaluated activation of NLRP1 inflammasome is associated with tumor growth, angiogenesis, and metastasis. Therefore, targeting NLRP1 activation could be a crucial strategy in anticancer therapy.
Arzuk E, Birim D, Armağan G.
europepmc   +4 more sources

Cytoprotective Activated Protein C Averts Nlrp3 Inflammasome–Induced Ischemia-Reperfusion Injury Via Mtorc1 Inhibition [PDF]

, 2017
Cytoprotection by activated protein C (aPC) after ischemia-reperfusion injury (IRI) is associated with apoptosis inhibition. However, IRI is hallmarked by inflammation, and hence, cell-death forms disjunct from immunologically silent apoptosis are, in ...
Al-Dabet, Moh\u27d Mohanad, Bock, Fabian, Braun-Dullaeus, Ruediger C., Camerer, Eric, Dockendorff, Chris, Elwakiel, Ahmed, Esmon, Charles T., Gadi, Ihsan, Ghosh, Sanchita, Griffin, John H., Huber, Tobias B., Isermann, Berend, Kohli, Shrey, Manoharan, Jayakumar, Nazir, Sumra, Ranjan, Satish, Shahzad, Khurrum   +16 more
core   +2 more sources

The NLRP1 Inflammasome Attenuates Colitis and Colitis-Associated Tumorigenesis [PDF]

The Journal of Immunology, 2015
Abstract Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are a diverse family of pattern recognition receptors that are essential mediators of inflammation and host defense in the gastrointestinal system. Recent studies have identified a subgroup of inflammasome forming NLRs that modulate the mucosal immune response ...
Tere M, Williams, Rachel A, Leeth, Daniel E, Rothschild, Sheryl L, Coutermarsh-Ott, Dylan K, McDaniel, Alysha E, Simmons, Bettina, Heid, Thomas E, Cecere, Irving C, Allen   +8 more
openaire   +2 more sources