Results 51 to 60 of about 9,154 (185)

Peroxynitrite activates the NLRP3 inflammasome cascade in SOD1(G93A) mouse model of amyotrophic lateral sclerosis [PDF]

, 2017
Neuroinflammation, characterized by the appearance of reactive microglial and astroglial cells, is one of the several pathogenic mechanisms of amyotrophic lateral sclerosis (ALS), a fast-progressing and fatal neurodegenerative disease.
Adamo, Sergio, Bellezza, Ilaria, Costanzi, Egidia, Grottelli, Silvia, Mezzasoma, Letizia, Minelli, Alba, Moresi, Viviana, Morozzi, Giulio, Peirce, Matthew J., Pigna, Eva, Scarpelli, Paolo   +10 more
core   +1 more source

Mechanistic basis for potassium efflux-driven activation of the human NLRP1 inflammasome. [PDF]

Proc Natl Acad Sci U S A
Rozario P, Pinilla M, Gorse L, Vind AC, Robinson KS, Toh GA, Firdaus MJ, Martínez JF, Kerk SK, Lin Z, Chambers JC, Bekker-Jensen S, Meunier E, Zhong F.   +13 more
europepmc   +2 more sources

The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. [PDF]

, 2010
Francisella tularensis, the causative agent of tularemia, infects host macrophages, which triggers production of the proinflammatory cytokines interleukin 1beta (IL-1beta) and IL-18. We elucidate here how host macrophages recognize F.
Alnemri, Emad S, Datta, Pinaki, Eisenlohr, Laurence, Fernandes-Alnemri, Teresa, Huang, Lan, Juliana, Christine, Kang, Seokwon, Landel, Carlisle P, McCormick, Margaret, McDermott, Erin, Solorzano, Leobaldo, Wu, Jianghong, Yu, Je-Wook   +12 more
core   +3 more sources

The Role of Non-canonical and Canonical Inflammasomes in Inflammaging

Frontiers in Molecular Neuroscience, 2022
Neurodegenerative diseases currently affect millions of people worldwide and continues to increase in the expanding elderly population. Neurodegenerative diseases usually involve cognitive decline and are among the top causes of death.
Brianna Cyr, Roey Hadad, Robert W. Keane, Robert W. Keane, Juan Pablo de Rivero Vaccari, Juan Pablo de Rivero Vaccari   +5 more
doaj   +1 more source

Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage

Journal of Neuroinflammation, 2017
Background Neuroinflammation mediated by NLRP1 (nucleotide-binding oligomerization domain (NOD)-like receptor protein 1) inflammasome plays an important role in many neurological diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD). Our
Biqiong Zhang, Yaodong Zhang, Wenning Wu, Tanzhen Xu, Yanyan Yin, Junyan Zhang, Dake Huang, Weizu Li   +7 more
doaj   +1 more source

Inflammatory caspases : key regulators of inflammation and cell death [PDF]

, 2014
The innate immune system represents the first line of defence against infectious agents, and co-ordinates cellular and molecular mechanisms that result in effective inflammatory and anti-microbial responses against pathogens.
Jiménez Fernandez, Daniel, Lamkanfi, Mohamed   +1 more
core   +2 more sources

TLR2 and Nod2 Mediate Resistance or Susceptibility to Fatal Intracellular Ehrlichia Infection in Murine Models of Ehrlichiosis [PDF]

, 2013
Our murine models of human monocytic ehrlichiosis (HME) have shown that severe and fatal ehrlichiosis is due to generation of pathogenic T cell responses causing immunopathology and multi-organ failure.
A Bafica, AA Abdul-Sater, AE Sehdev, Ankita Khandai, AR Shenoy, BC Mercier, BJ Hamburg, C Asseman, C Bitsaktsis, CA Dinarello, CC Chen, CD Paddock, CE Bryant, CJ Fichtenbaum, CM Fremond, DH Walker, EA Miao, EA Sotomayor, ED Carrol, GD Brown, GM Winslow, H Huang, H Okada, HL Stevenson, HL Stevenson, HL Stevenson, J Humann, JH Pedra, JM Pitt, JP Olano, JP Olano, JS Dumler, JS Haring, K Kersse, K Miura, K Miura, K Tsuchiya, K Yamauchi, Kelly A. Brayton, KL Hokeness-Antonelli, L Franchi, LM Delbridge, M Lamkanfi, M Lin, MA Rahman, MJ Crane, MM Rahman, N Ismail, N Ismail, N Ismail, N Ratnasamy, Nahed Ismail, NJ Davidson, Omar Al-Hendy, P Broz, P Ghose, Partho Chattoraj, PK Anand, Qin Yang, R Hanamsagar, R Medzhitov, RB Smeltz, RR Ganta, S Mariathasan, T Jia, WA Szymczak, Y Ogura, Y Tong   +67 more
core   +12 more sources

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3 [PDF]

, 2015
Inflammation that contributes to acute cerebrovascular disease is driven by the proinflammatory cytokine interleukin-1 and is known to exacerbate resulting injury.
Coutts, G., Cruickshank, S. M., Dénes, Ádám, Lénárt, Nikolett, Pelegrin, P.   +4 more
core   +1 more source

NLRP1 haplotypes associated with vitiligo and autoimmunity increase interleukin-1β processing via the NLRP1 inflammasome [PDF]

Proceedings of the National Academy of Sciences, 2013
Nuclear localization leucine-rich-repeat protein 1 (NLRP1) is a key regulator of the innate immune system, particularly in the skin where, in response to molecular triggers such as pathogen-associated or damage-associated molecular patterns, the NLRP1 inflammasome promotes caspase-1–dependent processing of bioactive interleukin-1β (IL-1β),
Levandowski, C.B., Mailloux, C.M., Ferrara, T.M., Gowan, K., Ben, S. van der, Jin, Y., McFann, K.K., Holland, P.J., Fain, P.R., Dinarello, C.A., Spritz, R.A.   +10 more
openaire   +3 more sources

NLRP1 inhibits lung adenocarcinoma growth through mediating mitochondrial dysregulation in an inflammasome-independent manner [PDF]

Brazilian Journal of Medical and Biological Research
NLRP1, the first identified inflammasome-forming sensor, is thought to be involved in cancer, yet its definite function in lung adenocarcinoma (LUAD) remains unclear. Herein, we explored the expression and function of NLRP1 in LUAD.
Chen-jing Lin, Guang-ang Tian, Wen-ya Zhao, Yi Tian, Yi-ru Liu, Dian-na Gu, Ling Tian   +6 more
doaj   +1 more source