Results 71 to 80 of about 9,154 (185)
Inflammasomes: Molecular Regulation and Implications for Metabolic and Cognitive Diseases [PDF]
, 2014 Inflammasomes are specialized signaling platforms critical for the regulation of innate immune and inflammatory responses. Various NLR family members (i.e., NLRP1, NLRP3, and IPAF) as well as the PYHIN family member AIM2 can form inflammasome complexes ...
Choi, Alexander J.S., Ryter, Stefan W.
core +1 more source
Dual Role for Inflammasome Sensors NLRP1 and NLRP3 in Murine Resistance to Toxoplasma gondii [PDF]
, 2013 Induction of immunity that limits Toxoplasma gondii infection in mice is critically dependent on the activation of the innate immune response. In this study, we investigated the role of cytoplasmic nucleotide-binding domain and leucine-rich repeat ...
Cirelli, Kimberly +11 more
core +4 more sources
Frontiers in Immunology, 2021 Fibrosis is the final common pathway of inflammatory diseases in various organs. The inflammasomes play an important role in the progression of fibrosis as innate immune receptors.
Wen-Juan Zhang +5 more
doaj +1 more source
Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]
, 2017 The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke +14 more
core +2 more sources
Analysis of the genetic basis of periodic fever with aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome. [PDF]
, 2015 PFAPA syndrome is the most common autoinflammatory syndrome in children from Western countries. In spite of its strong familial clustering, its genetic basis and inheritance pattern are still unknown.
Bedoni, N. +6 more
core +3 more sources
Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley +1 more source
Psychiatry and Clinical Psychopharmacology, 2018 INTRODUCTION: NOD-like receptors containing pyrin domain (NLRP) are cytosolic receptors belong to innate immune system and function as sensing bodies for danger signals by forming inflammasome complex which in turn produces caspase-1-mediated interleukin
Ceren Sahin Ozkartal +3 more
doaj +1 more source
Evidence of association of the NLRP1 gene with giant cell arteritis [PDF]
, 2017 Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity.
Blanco, Ricardo +23 more
core +1 more source
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death [PDF]
, 2016 Sensing bacterial products in the cytosol of mammalian cells by NOD-like receptors leads to the activation of caspase-1 inflammasomes, and the production of the pro-inflammatory cytokines interleukin (IL)-18 and IL-1β.
Alix, E +7 more
core +1 more source