Genetic Analysis of long-lived families reveals novel variants influencing high density-lipoprotein cholesterol [PDF]
Frontiers in Genetics, 2014 The plasma levels of high-density lipoprotein cholesterol (HDL) have an inverse relationship to the risks of atherosclerosis and cardiovascular disease, and have also been associated with longevity.
Mary F Feitosa +9 more
doaj +4 more sources
Structural basis for distinct inflammasome complex assembly by human NLRP1 and CARD8
Nature Communications, 2021 NLRP1 and CARD8 are two recently described sensor proteins for the human inflammasome complex. Here, the authors present the cryo-EM CARD filament structures of the NLRP1 and CARD8 activating domains, which reveal how NLRP1 and CARD8 discriminate between
Kim S Robinson +2 more
exaly +2 more sources
The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex. [PDF]
PLoS PathogensInflammasomes function as immune-signaling platforms that were assembled following detection of pathogens. NLRP1 and CARD8 are related inflammasomes that use their C-terminal (CT) fragments containing a caspase recruitment domain (CARD) and the UPA ...
Pan-Pan Liu +5 more
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Expression of nucleotide-binding oligomerization domain-like receptor protein 1 in patients with acute myocardial infarction and its relationship with clinical prognosis [PDF]
Frontiers in Cardiovascular MedicineBackgroundAcute myocardial infarction (AMI) remains the leading cause of cardiovascular-related mortality worldwide, with inflammation significantly influencing its progression and prognosis.
Wenhao Qian +6 more
doaj +2 more sources
p62 mRNA suppresses NLRP1 expression in cutaneous SCC cells through miR-34a-5p [PDF]
Cell Death and DiseaseThe inflammasome sensor NLRP1 is mainly expressed by epithelial cells including keratinocytes of human skin. Germline gain-of-function mutations in NLRP1 cause inflammatory skin syndromes and predispose patients to the development of cutaneous squamous ...
Paulina Hennig +5 more
doaj +2 more sources
The NLRP1 Emerges as a Promising Therapeutic Target and Prognostic Biomarker Across Multiple Cancer Types: A Comprehensive Pan‐Cancer Analysis [PDF]
Cancer MedicineIntroduction Nod‐like receptor family pyrin domain containing 1 (NLRP1) serves as the central component of the inflammasome complex and has emerged as a potential contributor to cancer development.
Leila Habibipour +5 more
doaj +2 more sources
Anti-Inflammasome Effect of Impressic Acid on Diesel Exhaust Particulate Matter-Induced NLRP1 Inflammasome via the Keap1/p62/Nrf2-Signaling Pathway in Keratinocytes [PDF]
AntioxidantsDiesel exhaust particulate (DEP) is widely recognized to weaken lung function and skin diseases. When the skin, which defends against external factors, is exposed to PM2.5, various chronic inflammatory diseases occur. When keratinocytes recognize harmful
Seung Yeon Lee +6 more
doaj +2 more sources
Expression levels of MIF, NLRP1 and FOXP3 genes along with biomarker levels in patients with active form of non-segmental generalized vitiligo: A study in South Indian population [PDF]
Songklanakarin Journal of Science and Technology (SJST), 2022 Vitiligo, the most widespread hypopigmentary syndrome, is considered to be a multifactorial disease in which the active melanocytes are lost. Vitiligo has been studied in a variety of ways, and several genes have been implicated.
Alokananda Chakraborty +10 more
doaj +1 more source
BNIP3-mediated mitophagy aggravates placental injury in preeclampsia via NLRP1 inflammasome [PDF]
Frontiers in ImmunologyIntroductionPreeclampsia (PE) is a hypertensive disorder of pregnancy characterized by pronounced placental oxidative stress and inflammatory damage. However, the contribution of mitophagy to inflammation-induced placental injury in PE remains unclear ...
Man Zhao +9 more
doaj +2 more sources
The CARD8 T60 variant associates with NLRP1 and negatively regulates its activation
Frontiers in Immunology, 2022 The NLRP1 inflammasome functions as canonical cytosolic sensor in response to intracellular infections and is implicated in auto-inflammatory diseases. But the regulation and signal transduction mechanisms of NLRP1 are incompletely understood.
Zhihao Xu +17 more
doaj +1 more source